Corticotropin-releasing factor suppresses the afterhyperpolarization in cerebellar Purkinje neurons.

Abstract:

:Corticotropin-releasing factor (CRF) is present in climbing fibers and their terminations on Purkinje neurons. To determine whether CRF may have a postsynaptic action in this pathway, CRF effects on the electrophysiological properties of cultured cerebellar Purkinje neurons were studied. CRF produced a dose-dependent reduction of the amplitude of the afterhyperpolarization (AHP) which follows a current-induced spike train. The effect of CRF on the AHP was specific in that CRF did not significantly alter input resistance, membrane potential, amplitude of the depolarizing-off response produced at the termination of a hyperpolarizing current pulse, or the number of depolarization-induced simple spikes. Suppression of the AHP by CRF may be one mechanism by which CRF regulates the response of Purkinje neurons to other transmitters in the climbing fiber pathway or in other inputs to Purkinje neurons.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Fox EA,Gruol DL

doi

10.1016/0304-3940(93)90358-r

subject

Has Abstract

pub_date

1993-01-04 00:00:00

pages

103-7

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(93)90358-R

journal_volume

149

pub_type

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