Abstract：
:Deficit in balance control is a common and often an initial disabling symptom of multiple sclerosis (MS). The aim of the study was to investigate the organization of anticipatory and compensatory postural adjustments in individuals with MS dealing with external perturbations. Ten individuals with MS and ten age-and-gender matched healthy controls were exposed to external perturbations applied at the shoulder level. The perturbations were either predictable or unpredictable as subjects stood with eyes open or closed. Electrical activity of six leg and trunk muscles as well as displacements of the center of pressure (COP) were recorded and quantified within the time intervals typical of anticipatory (APAs) and compensatory (CPAs) postural adjustments. Individuals with MS demonstrated delayed anticipatory onsets of muscle activity and smaller anticipatory COP displacements as compared to healthy control subjects. The deficiency of the APAs was associated with increased displacements of the COP during the balance restoration phase. The results demonstrate the underlying impairment in anticipatory postural control of individuals with MS. The study outcome provides a background for development of rehabilitation strategies focused on balance restoration in people with MS.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Aruin AS,Kanekar N,Lee YJdoi
10.1016/j.neulet.2015.02.050subject
Has Abstractpub_date
2015-03-30 00:00:00pages
182-186eissn
0304-3940issn
1872-7972pii
S0304-3940(15)00164-0journal_volume
591pub_type
杂志文章abstract：:We examined by immunohistochemistry the effect of salt loading on the expression of tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AADC), and GTP cyclohydrolase I (GCH) in Purkinje cells of the mouse cerebellum. In control mice, only a few Purkinje cells were positive for TH or AADC. No Purkinje cells...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(95)11716-a
更新日期：1995-07-14 00:00:00
abstract：:In the superoxide dismutase 1 (SOD1)(G93A G1H) transgenic mouse, the primary pathology and disease signs are associated with the degeneration of motor neurons in the lumbar spinal cord. It is unclear if the descending motor pathways from the cortex and brainstem are also compromised. The retrograde tracer Fluorogold w...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(02)00944-8
更新日期：2002-10-31 00:00:00
abstract：:The processing of sound information is mediated by the cochlea and the central auditory system. Among the central auditory system, the inferior colliculus (IC) has leading roles in the acoustic processing. In a previous study, we demonstrated psychiatric disorder-related behavioral abnormalities in a genetically modif...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2014.02.061
更新日期：2014-04-30 00:00:00
abstract：:Previous studies have shown an association between diabetes mellitus and impairments in learning and memory. These deficits were partially reversed by the use of insulin. Due to the fact that exercise has positive effects on many physiological systems, including the central nervous system, the present study, evaluated...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2009.03.052
更新日期：2009-05-15 00:00:00
abstract：:To elucidate the early histopathological changes after transient focal cerebral ischemia, we made 1 h intraluminal occlusion of the middle cerebral artery on rats. After different reperfusion time, from minutes to 3 days, argyrophil III method was used for the demonstration of 'collapsed' (argyrophilic, dark) neurons....
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(93)90562-y
更新日期：1993-11-12 00:00:00
abstract：:The major human neurodegenerative diseases are characterised by ubiquitin-positive intraneuronal inclusions, however the precise nature of the ubiquitin modifications in these structures is unclear. Using a monoclonal antibody specific for Lys63-linked polyubiquitin we have performed the first immunohistochemical anal...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2009.05.074
更新日期：2009-09-04 00:00:00
abstract：:In the present study we sought to investigate the signal transduction mechanisms that underlie the alpha2-adrenergic receptor (AR)-induced, subtype-specific neuronal differentiation of PC12 cells. Alpha2-ARs induced NF-kappaB transcriptional activity and p21(waf-1) gene transcription in the same subtype-specific manne...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2006.03.066
更新日期：2006-07-24 00:00:00
abstract：:The anti-neuroinflammatory effect of Astragaloside IV (ASI) has been reported, but its underlying mechanisms are unclear. This study is further to explore the underlying mechanism of ASI on anti-neuroinflammatory effect in LPS induced microglia cells. The result showed ASI significantly reduced the production of infla...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2017.12.039
更新日期：2018-02-14 00:00:00
abstract：:Whether or not chronic L-dopa treatment (100 mg/kg, intraperitoneally (i.p.), twice daily for 4 weeks) alters lipid peroxidation in the brain as an indicator of neuronal damage was examined in normal mice and mice in which catecholamine (CA) neurons had been injured previously by the administration of 6-hydroxydopamin...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(94)90603-3
更新日期：1994-04-25 00:00:00
abstract：:Pitch and duration -- either as written symbols or in auditory form -- are the basic structural properties in tones that form a melodic sequence. From the cognitive perspective, it is still a matter of debate whether, and at which processing stage, these two factors are processed independently or interdependently. The...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.05.101
更新日期：2008-08-15 00:00:00
abstract：:Muscarinic cholinoreceptors regulate the neurosecretion process in vertebrate neuromuscular junctions. The diversity of muscarinic effects on acetylcholine (ACh) secretion may be attributed to the different muscarinic subtypes involved in this process. In the present study, the location of five muscarinic receptor sub...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2017.04.015
更新日期：2017-05-10 00:00:00
abstract：:Astrocytes in the CNS produce inflammatory mediators in response to several stimuli and cytokines. Here we investigated the in vitro effect of leptin on inducible nitric oxide synthase (iNOS) expression in a glioma cell line (C6). After hormone stimulation, culture media were analysed for accumulated stable oxidation ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2005.11.022
更新日期：2006-03-27 00:00:00
abstract：:The nucleus raphe magnus belongs to the thermoafferent system. Following iontophoretic choleratoxin b injections in its rostral part, a substantial to large number of anterogradely labeled varicose fibres were observed in the medial and lateral preoptic areas, the bed nucleus, the substantia innominata, the ventral pa...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(96)13013-5
更新日期：1996-10-04 00:00:00
abstract：:The possible involvement of 2-amino-4-phosphonobutyrate (APB) recognition sites in mechanisms enabling the maintenance of long-term potentiation (LTP) was investigated in rat hippocampal slices. The action of D(-)- and L(+)-isomers of APB was tested on orthodromic EPSP and spike responses recorded extracellularly from...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(89)90504-1
更新日期：1989-03-27 00:00:00
abstract：:This work explores the hypothesis that perturbations caused by ethanol on the regulatory role of retinoids in brain development may be a mechanism involved in the neuropathology of fetal alcohol syndrome. The interaction of ethanol and retinoic acid (RA) on RA receptor (RAR) beta and glial fibrillary acidic protein (G...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(00)01538-x
更新日期：2000-11-17 00:00:00
abstract：:AMP-activated protein kinase (AMPK) was recently suggested to have a pro-apoptotic effect although its primary function is believed to mediate cellular adaptation to metabolic stresses. Here, we investigated the effect of the AMPK activator 5-aminoimidazole-4-carboxamide-ribonucleoside (AICAR) on oxidative stress-indu...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2003.10.012
更新日期：2004-01-16 00:00:00
abstract：:Activation of microglia is a central part of the chronic inflammatory process in Alzheimer disease (AD). The monocyte chemoattractant protein-1 (MCP-1) is a chemokine that plays a role in microglial migration and accumulation at sites of beta-amyloid deposition in senile plaques in the AD brain. A polymorphism in the ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.01.035
更新日期：2004-04-22 00:00:00
abstract：:Single unit recordings were performed in the nuclei raphe dorsalis (RD) and raphe magnus (RM) of semi-chronic prepared cats during spontaneous or cryogenically induced sleep. Of the RD neurons 75% showed a discharge pattern which decreased during slow wave sleep and paradoxical sleep (PS); such a decrease in spiking w...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(81)90236-6
更新日期：1981-07-02 00:00:00
abstract：:Corticotropin-releasing factor (CRF) is present in climbing fibers and their terminations on Purkinje neurons. To determine whether CRF may have a postsynaptic action in this pathway, CRF effects on the electrophysiological properties of cultured cerebellar Purkinje neurons were studied. CRF produced a dose-dependent ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(93)90358-r
更新日期：1993-01-04 00:00:00
abstract：:Three variations of the in vitro neonatal rat spinal cord preparation were used to investigate motor responses to stimulation of the ventrolateral funiculus (VLF). In a partially hemisected spinal cord preparation, stimuli elicited frequency-dependent activity in lumbar ventral roots that outlasted the stimulus train ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(95)99208-m
更新日期：1995-06-09 00:00:00
abstract：PURPOSE:The aim of this study was to estimate the effect of altitude (1500m vs. 3200m) on balance strategies, and to determine the influence of age (> or <40 years) and expertise (> or <20days of mountain climbing/year) on postural stability at altitude. METHOD:Eighty-nine volunteer mountaineers were tested at 1500m, ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2017.06.010
更新日期：2017-09-14 00:00:00
abstract：:Assessing the result of conceptual change (i.e., whether an individual has come to correctly understand a science concept) is important in science education, however traditional assessment methods lack objectivity. In this study, permutation entropy (PE) based complexity, a kind of entropy used to quantify the complex...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2019.02.015
更新日期：2019-04-23 00:00:00
abstract：:Parkin gene mutations are by far the most common mutations in both familial Parkinson's disease (PD) and sporadic PD. Approximately, 50% of parkin mutations is exon dosage mutations (i.e., deletions and duplications of entire exons). Here, we first established a MLPA assay for quick detection of parkin exon rearrangem...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2015.07.046
更新日期：2015-09-14 00:00:00
abstract：:The present magnetoencephalographic study was conducted in order to assess the accuracy of dipole localizations for the movement-evoked field component 1 (MEF 1). Three male subjects were requested to perform self-paced flexions of their index finger and thumb in repeated sessions of 60 trials while the neuromagnetic ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(96)12952-9
更新日期：1996-08-30 00:00:00
abstract：:In anesthetized rats, injections of a 0.5 mM glutamate solution into the locus coeruleus (LC) reversibly increased the amplitude of the population spike evoked in CA1 by stimulation of the Schaffer-commissural fiber tract. This effect was absent in N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4)-treated, noradren...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(86)90112-6
更新日期：1986-03-28 00:00:00
abstract：:Extracellular field-potential recordings and measurements of the extracellular concentration of potassium ([K+]o) were made in layers II and III of the adult rat entorhinal cortex in a slice preparation. Two types of spontaneous, synchronous potentials were induced by the convulsant drug 4-aminopyridine (4AP, 50 micro...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(95)11248-u
更新日期：1995-02-13 00:00:00
abstract：:Experiments were conducted to examine whether renal sympathetic nerve activity (RSNA) and water intake in response to central salt-loading or angiotensin II (A II) differ between freely-moving Dahl salt-sensitive (DS) and -resistant (DR) rats maintained on a low-salt diet. Intracerebroventricular (i.c.v.) administrati...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(98)00005-6
更新日期：1998-02-06 00:00:00
abstract：:It is debated whether non-affected relatives of patients with affective disorders share a specific brain structure endophenotype. Aim of this work is to explore the medial temporal morphology in affected and non-affected members of a family with mood disorders. Hippocampi and amygdalae were manually traced from the 3D...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2009.10.067
更新日期：2010-01-04 00:00:00
abstract：:MK801, a non-competitive NMDA receptor antagonist, leads to a dramatic induction of c-fos-like protein in neurons in deep layers of the neocortex, in dorsal and ventral midline thalamic nuclei and in neurons in the central grey of rat brain. This induction of c-fos by MK801 is dose- and time-dependent occurring within...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(90)90294-j
更新日期：1990-05-31 00:00:00
abstract：:This experiment examined the hypothesis that aging reduces the coupling between system components, resulting in a loss of complexity in behavior. Young (18-23 years), old (60-65 years), and older old (70-75 years) subjects performed rhythmical movement and postural tasks with the index finger. Irregularity of the acce...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2007.12.056
更新日期：2008-03-12 00:00:00
