MK801 induces c-fos protein in thalamic and neocortical neurons of rat brain.

Abstract:

:MK801, a non-competitive NMDA receptor antagonist, leads to a dramatic induction of c-fos-like protein in neurons in deep layers of the neocortex, in dorsal and ventral midline thalamic nuclei and in neurons in the central grey of rat brain. This induction of c-fos by MK801 is dose- and time-dependent occurring within 2 h and dissipating by 24 h after injection (0.5-8.0mg/kg, i.p.). The mechanism of this paradoxical induction of c-fos by MK801 is unclear, however the pattern of induction appears to follow the distribution of the antagonist-preferring NMDA receptor site.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Dragunow M,Faull RL

doi

10.1016/0304-3940(90)90294-j

subject

Has Abstract

pub_date

1990-05-31 00:00:00

pages

144-50

issue

2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(90)90294-J

journal_volume

113

pub_type

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