Effects of the novel TRPV1 receptor antagonist SB366791 in vitro and in vivo in the rat.

abstract：:Interleukin-18 (IL-18) is a pro-inflammatory cytokine and an important mediator of peripheral inflammation and host immune response. IL-18 functions through its binding with the IL-18 receptor (IL-18R), which consists of two chains, an IL-18-binding α chain (IL-18Rα) and a signaling β chain. IL-18 and IL-18R are expre...

journal_title：Neuroscience letters

authors： Kuwahara-Otani S,Maeda S,Kobayashi K,Minato Y,Tanaka K,Yamanishi K,Hata M,Li W,Hayakawa T,Noguchi K,Okamura H,Yagi H

更新日期：2017-05-22 00:00:00

abstract：:FasL has been shown to induce angiogenesis in vivo, however, the mechanism remains to be determined. We have previously shown that Fas ligation induces expression of chemokines such as interleukin-8 by human astrogliomas, which may partially explain the in vivo angiogenic property of FasL. Intercellular adhesion molec...

journal_title：Neuroscience letters

authors： Choi K,Benveniste EN,Choi C

更新日期：2003-11-27 00:00:00

abstract：:Convulsions were induced in rats by a single injection of pentylenetetrazol (PTZ) and [3H]L-2-amino-4-phosphonobutyrate ([3H]L-AP4) in vitro receptor autoradiography was used to evaluate the effects on the expression of group III metabotropic glutamate receptors. Significant increases by 60-80% in [3H]L-AP4 binding wa...

journal_title：Neuroscience letters

authors： Thomsen C

更新日期：1999-04-30 00:00:00

abstract：:The soluble fraction of rat brain cortex yielded an antioxidant factor that inhibits the autoxidation of ascorbic acid at physiological pH. The measurements were based on spectrophotometric detection of ascorbic acid at 265 nm in a physiological salt solution of the Krebs-Ringer type, pH 7.4, or in sodium phosphate bu...

journal_title：Neuroscience letters

authors： Kovachich GB,Mishra OP

更新日期：1982-12-23 00:00:00

abstract：:Oxygen tension is critical for proliferation of human and murine midbrain-derived neural precursor cells (mNPCs). Lack of hypoxia-inducible factor-1α (HIF1α) impairs midbrain dopaminergic neurogenesis which could be rescued by vascular endothelial growth factor (VEGF) via VEGFR-2 signaling. Here, we conditionally inac...

journal_title：Neuroscience letters

authors： Hermann A,Loewenbrück KF,Boldt Ä,Fiedler C,Maisel M,Kalucka J,Schwarz J,Breier G,Storch A

更新日期：2013-10-11 00:00:00

abstract：:Rat brain slices containing the nucleus tractus solitarius loaded with [3H]5-hydroxytryptamine ([3H]5-HT) for superfusion were stimulated at (3 Hz, 25 mA, 1 min) resulting in fractional release ratios S2/S1 of 0.89 for [3H]5-HT in the presence of the serotonin uptake inhibitor 1.0 microM 6-nitroquipazine (6-NQ). alpha...

journal_title：Neuroscience letters

authors： Helfman CC,Anderson GF,Barraco RA

更新日期：1995-04-14 00:00:00

abstract：:The regional cerebral blood flow (rCBF) was measured with positron emission tomography in eight normal volunteers with the purpose of measuring rCBF changes related to the comprehension of an unfamiliar spoken languages. When attempting to comprehend the meaning of words, the left hemisphere showed dominant increases ...

journal_title：Neuroscience letters

authors： Kawashima R,Itoh M,Hatazawa J,Miyazawa H,Yamada K,Matsuzawa T,Fukuda H

更新日期：1993-10-14 00:00:00

abstract：:The antigenic components of Lewy bodies in the cerebral cortex and substantia nigra in 5 cases of diffuse Lewy body disease were examined by immunocytochemistry, using antibodies to neurofilaments (in the phosphorylated or non-phosphorylated forms); to ubiquitin; to the microtubule-associated proteins MAP1, MAP2 and t...

journal_title：Neuroscience letters

authors： Galloway PG,Bergeron C,Perry G

更新日期：1989-05-22 00:00:00

abstract：:The gamma-aminobutyric acid (GABA) antagonist (+/-)-bicuculline inhibits specific [3H]strychnine binding to postsynaptic glycine receptor sites in rat spinal cord synaptosomal membranes with an inhibition constant of about 5 microM, which is fairly similar to its inhibition constant reported for the GABA receptor. Thi...

journal_title：Neuroscience letters

authors： Goldinger A,Müller WE

更新日期：1980-01-01 00:00:00

abstract：:Cultures were produced from retinas taken from human foetuses. Specific cells in culture have the capacity to take up exogenous serotonin, which was then visualized by immunofluorescence using an antisera to serotonin. The known serotonergic uptake blocker, chlorimipramine, inhibited the uptake of the amine while benz...

journal_title：Neuroscience letters

authors： Osborne NN,Beaton DW

更新日期：1985-04-09 00:00:00

abstract：:Preterm infants undergo several painful procedures during their stay in neonatal intensive care units. Previous studies suggest that early painful experiences may have an impact on brain development. Here, we used an animal model to investigate the effect of neonatal pain on the generation of new neurons in the dentat...

journal_title：Neuroscience letters

authors： Leslie AT,Akers KG,Martinez-Canabal A,Mello LE,Covolan L,Guinsburg R

更新日期：2011-08-26 00:00:00

abstract：:Previous tracer studies have revealed the sacculus to be connected to the vestibular and cochlear nuclei in the guinea pig. Due to its own innervation pattern, an anterior and posterior part of the sacculus can be distinguished. The present study investigated whether the two parts differ concerning their fiber contrib...

journal_title：Neuroscience letters

authors： Gstoettner W,Burian M,Zundritsch R,Mayr R

更新日期：1991-01-28 00:00:00

abstract：:IgGs from two LEMS patients applied to human neuroblastoma IMR32 cells reduced the density of low- (LVA; T) and high-threshold (HVA; L and N) Ba2+ currents by different percentages: 36% (LVA) and 56% (HVA) for one and 48% and 45% for the other. A pharmacological assay of IgGs action based on the block of L-type channe...

journal_title：Neuroscience letters

authors： Grassi C,Magnelli V,Carabelli V,Sher E,Carbone E

更新日期：1994-11-07 00:00:00

abstract：:In the neuritic plaques of Alzheimer's disease, abnormal neuritic processes cluster around a core of beta-amyloid protein. Previous data have shown that beta 1-28, a peptide homologous to the first 28 amino acid residues of beta-amyloid protein, enhanced survival without affecting neuritic extension or branching in cu...

journal_title：Neuroscience letters

authors： Whitson JS,Glabe CG,Shintani E,Abcar A,Cotman CW

更新日期：1990-03-14 00:00:00

abstract：:Mouse acetylcholine receptors (AChRs) consisting of either the embryonic form (2 alpha, 1 beta, 1 delta and 1 gamma) or the adult form (2 alpha, 1 beta, 1 delta and 1 epsilon) were expressed in Xenopus laevis oocytes. As expected, the single channel conductance was approximately 52 pS and the exponential decay time co...

journal_title：Neuroscience letters

authors： Liu E,Hamill OP,Salpeter MM

更新日期：1994-06-06 00:00:00

abstract：:Calcium antagonists inhibit both the Ca2(+)-dependent and -independent release of endogenous glutamate from intact synaptosomes. In the present study, the inhibitory potency of several different classes of calcium antagonists were determined under conditions that control for an effect of these compounds on the Ca2(+)-...

journal_title：Neuroscience letters

authors： Terrian DM,Dorman RV,Gannon RL

更新日期：1990-11-13 00:00:00

abstract：:Hypoxia is one of the important physiological stimuli that are often associated with a variety of pathological states such as ischemia, respiratory diseases, and tumorigenesis. In the central nervous system, hypoxia that is accompanied by cerebral ischemia not only causes neuronal cell injury, but may also induce path...

journal_title：Neuroscience letters

authors： Suk K

更新日期：2004-08-12 00:00:00

abstract：:Nociceptin/orphanin FQ (NC) and its receptor (OP(4)) have been implicated in the regulation of various functions including nociception. [Nphe(1)]NC(1-13)NH(2) (Nphe) is a selective OP(4) antagonist which prevents the pronociceptive effects of supraspinal NC and causes per se a naloxone-insensitive antinociceptive effe...

journal_title：Neuroscience letters

authors： Di Giannuario A,Rizzi A,Pieretti S,Guerrini R,Bertorelli R,Salvadori S,Regoli D,Calo G

更新日期：2001-12-04 00:00:00

abstract：:beta-Alanine (beta-ALa) is a structural analog of the putative inhibitory transmitters gamma-aminobutyric acid (GABA) and glycine. beta-ALa itself depresses firing in cultured mouse spinal cord (SC) neurons, by selectively increasing membrane conductance to chloride ions. Patch clamp recordings now reveal that beta-AL...

journal_title：Neuroscience letters

authors： Mathers DA,Grewal A,Wang YH

更新日期：1990-01-01 00:00:00

abstract：:This study examines the effect of acetylcholine (Ach) on parasympathetic vagal neurons in the dorsal motor nucleus of the vagus (DMNX). Patch-clamp techniques were utilized to examine voltage and ligand-gated currents in visualized DMNX neurons in an in vitro slice. Ach (100 microM) activated an inward current, -196.4...

journal_title：Neuroscience letters

authors： Neff RA,Hansen MK,Mendelowitz D

更新日期：1995-08-11 00:00:00

abstract：:In the hypothalamus of androgen-insensitive testicular feminized (Tfm) mice the normal pattern of immunohistochemical staining for glial fibrillary acidic protein (GFAP) is markedly different from normal. Along the borders of the third ventricle and in the dorsomedial and arcuate nuclei, the numbers of stained astrocy...

journal_title：Neuroscience letters

authors： McQueen JK,Wright AK,Arbuthnott GW,Fink G

更新日期：1990-10-02 00:00:00

abstract：:Gangliosides isolated from the brain of patients with Creutzfelt-Jakob (C-J) disease were analyzed. The ganglioside current was abnormally low, and the percentage distributions of individual gangliosides and the long-chain base compositions were abnormal. The C20-sphingosine contents of all the ganglioside fractions w...

journal_title：Neuroscience letters

authors： Tamai Y,Ohtani Y,Miura S,Narita Y,Iwata T,Kaiya H,Namba M

更新日期：1979-01-01 00:00:00

abstract：:The mouse model of transcranial permanent occlusion of the middle cerebral artery (tpMCAO) is widely used in stroke research. Here we quantified infarct size using a conventional histological method at several post-ischaemic times, going beyond the commonly analysed period of up to 2 days, following artery occlusion. ...

journal_title：Neuroscience letters

authors： Henrich-Noack P,Baldauf K,Reiser G,Reymann KG

更新日期：2008-02-20 00:00:00

abstract：:Cannabinoid CB1 receptor (CB1R) is highly expressed in the mesocorticolimbic system and associated with drug craving and relapse. Clinical trials suggest that CB1R antagonists may represent new therapies for drug addiction. However, the downstream signaling of CB1R is not fully elucidated. In the present study, we inv...

journal_title：Neuroscience letters

authors： Zhang J,Wang N,Chen B,Wang Y,He J,Cai X,Zhang H,Wei S,Li S

更新日期：2016-09-06 00:00:00

abstract：:The presence of neuromelanic pigment in neurons of the rat substantia nigra (SN) is a matter of controversy. The presence of neuromelanin in the SN of 15--24-month-old rats was investigated by electron microscopy (EM) and the findings compared to the morphology and distribution of neuromelanin in SN of dogs. In the ra...

journal_title：Neuroscience letters

authors： DeMattei M,Levi AC,Fariello RG

更新日期：1986-12-03 00:00:00

abstract：:Mechanosensitivity is a crucial but poorly understood property of the sensory nervous system. Transient receptor potential (TRP) channels, which have been found to be responsible for the detection of other sensory stimuli such as temperature and pungent chemicals, have been suggested to also recognize stretch or press...

journal_title：Neuroscience letters

authors： Staaf S,Maxvall I,Lind U,Husmark J,Mattsson JP,Ernfors P,Pierrou S

更新日期：2009-06-19 00:00:00

abstract：:Aromatic L-amino acid decarboxylase (AADC) decarboxylates L-DOPA and 5-hydroxytryptophan into dopamine and serotonin, respectively. Starting from a rat AADC cDNA clone isolated in our laboratory, we produced a beta-galactosidase-AADC fusion protein in E. coli. It was purified from inclusion bodies and injected into a ...

journal_title：Neuroscience letters

authors： Krieger M,Tillet Y,Gros F,Thibault J

更新日期：1993-04-16 00:00:00

abstract：:The goal of this study was to examine the coupling between visual information and body sway with binocular and monocular vision at two distances from the front wall of a moving room. Ten participants stood as still as possible inside of a moving room facing the front wall in conditions that combined room movement with...

journal_title：Neuroscience letters

authors： Moraes R,Lopes AG,Barela JA

更新日期：2009-09-04 00:00:00

abstract：:We examined the caudate spindle in control and pargyline-pretreated rats following bilateral application of 3 doses (15, 50 and 150 micrograms/site) of dopamine (DA) into the caudate nucleus. The highest dose of DA (150 micrograms) suppressed the spindle, whereas lower doses (15, 50 micrograms) enhanced the spindle in...

journal_title：Neuroscience letters

authors： Okuyama S,Hashimoto S,Aihara H

更新日期：1985-08-16 00:00:00

abstract：:Sex steroids have potent effects on mood, mental state and cognition. Our previous findings and those of others suggest that these effects may be due at least in part to estradiol actions on central serotonergic mechanisms. Specifically, estradiol-17beta in its acute positive feedback mode for gonadotropin release in ...

journal_title：Neuroscience letters

authors： Sumner BE,Grant KE,Rosie R,Hegele-Hartung Ch,Fritzemeier KH,Fink G

更新日期：2007-04-24 00:00:00