Abstract:
:IgGs from two LEMS patients applied to human neuroblastoma IMR32 cells reduced the density of low- (LVA; T) and high-threshold (HVA; L and N) Ba2+ currents by different percentages: 36% (LVA) and 56% (HVA) for one and 48% and 45% for the other. A pharmacological assay of IgGs action based on the block of L-type channel by nifedipine and on the delayed activation of N-type channel by noradrenaline, indicated a preferential inhibition of the N-type current in IMR32 cells (55% and 47% for the two patients). The L-type current, contributing to approximately one-third of the total, was also depressed by LEMS IgGs but to a minor degree (49% and 30%). Except for an increase of single N-type channel inactivation, LEMS antibodies preserved the elementary properties of single HVA channels, suggesting that the macroscopic current reduction after IgGs treatment is likely due to a decrease in the number of active HVA Ca2+ channels.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Grassi C,Magnelli V,Carabelli V,Sher E,Carbone Edoi
10.1016/0304-3940(94)90558-4subject
Has Abstractpub_date
1994-11-07 00:00:00pages
50-6issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(94)90558-4journal_volume
181pub_type
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