Abstract：
:This study examines the effect of acetylcholine (Ach) on parasympathetic vagal neurons in the dorsal motor nucleus of the vagus (DMNX). Patch-clamp techniques were utilized to examine voltage and ligand-gated currents in visualized DMNX neurons in an in vitro slice. Ach (100 microM) activated an inward current, -196.4 +/- 56.9 pA at -80 mV (n = 15) that was accompanied by a decrease in membrane resistance of 48.6 +/- 9.2% in a population of DMNX neurons. The reversal potential for this ligand-gated current was -11.3 +/- 11.5 mV. The specific agonist nicotine (200 microM) elicited similar responses. Nicotine decreased membrane resistance by 60.9 +/- 4.3% and activated an inward current (-215.7 +/- 45.7 pA at -80 mV) that reversed at -12.7 +/- 20.4 mV (n = 16). Bethanecol (100 microM), a specific muscarinic agonist, had no effect. Neither Ach or nicotine had any effect on the voltage-gated sodium and outward potassium currents present in these neurons.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Neff RA,Hansen MK,Mendelowitz Ddoi
10.1016/0304-3940(95)11807-9subject
Has Abstractpub_date
1995-08-11 00:00:00pages
163-6issue
3eissn
0304-3940issn
1872-7972pii
0304394095118079journal_volume
195pub_type
杂志文章abstract：:Chronological changes of dopamine D1 receptor binding were determined in the strionigral system of the rat brain by using [3H]SCH 23390, a highly selective dopamine D1 antagonist, in vitro autoradiography after 90 min of right middle cerebral artery (MCA) occlusion and after such occlusion followed by different period...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(92)90533-d
更新日期：1992-01-06 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2003.12.127
更新日期：2004-04-08 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(94)90665-3
更新日期：1994-05-19 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(94)91092-8
更新日期：1994-07-04 00:00:00
abstract：:A seizure disorder, characterized by sporadic tonic/clonic seizures has been identified in a strain of mice carrying the weaver (wv) gene. Breeding studies and a review of the literature indicate that this is either a property of the wv gene or linked to it tightly. ...
journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1989-01-16 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(95)11958-y
更新日期：1995-09-22 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2005-05-06 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2007.07.002
更新日期：2007-08-16 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2007-02-08 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2004-09-16 00:00:00
abstract：:Presenilin1 (PSEN1) 1143T and G384A mutations give rise to severe early-onset Alzheimer's disease in two extensively studied Belgian families. In the present study, we examined the effect of PSEN1 1143T and G384A mutations on tau phosphorylation in human SH-SY5Y and mouse Neuro-2a neuroblastoma cell lines that were tr...
journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1999-07-09 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(90)90584-v
更新日期：1990-07-13 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(87)90366-1
更新日期：1987-10-16 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2002-06-28 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2002-05-03 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1985-07-04 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2006.02.042
更新日期：2006-05-29 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(87)90225-4
更新日期：1987-12-16 00:00:00
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.07.092
更新日期：2004-11-11 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2012-04-04 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2020.135272
更新日期：2020-09-25 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.03.063
更新日期：2004-06-10 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(00)01452-x
更新日期：2000-10-06 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.05.056
更新日期：2004-08-19 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(93)90152-b
更新日期：1993-10-14 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(90)90771-z
更新日期：1990-10-30 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(81)90360-8
更新日期：1981-06-12 00:00:00
