Phenytoin suppresses spontaneous ectopic discharge in rat sciatic nerve neuromas.

abstract：:Nociceptin/orphanin FQ (N/OFQ) is an opioid-like neuropeptide that has been shown to cause peripheral sensitization of knee joint afferents; however, the effect of the peptide on joint pain behaviour is unknown. In addition to having a direct effect on peripheral nerves, N/OFQ has also been shown to activate connectiv...

journal_title：Neuroscience letters

authors： McDougall JJ,Larson SE

更新日期：2006-05-01 00:00:00

abstract：:The cellular location of kappa-opioid binding sites in the guinea pig cerebellum has been investigated. kappa-Opioid sites were labelled using [3H]ethylketocyclazocine in the presence of mu- and delta-blocking ligands. In vitro autoradiography demonstrated that this kappa-opioid binding was localized predominantly in ...

journal_title：Neuroscience letters

authors： Bunn SJ,Wilkin GP

更新日期：1988-01-11 00:00:00

abstract：:The Nef protein of human immunodeficiency virus type 1 (HIV-1) is abundantly expressed in HIV-1-infected astrocytes and shares amino acid sequence homology to alpha-scorpion toxins which bind to potassium channels. Here we report effects of recombinant Nef and alpha-scorpion toxins on membrane potassium transport in h...

journal_title：Neuroscience letters

authors： Kort JJ,Jalonen TO

更新日期：1998-07-17 00:00:00

abstract：:The cognitive deficits observed in schizophrenia are considered a core feature of the disease. Neuregulin-1 is a risk gene for schizophrenia that is involved in many neurodevelopmental and synaptic plasticity-related processes relevant to schizophrenia. Here, we have utilized a rat model (Nrg1(Tn)), which is hypomorph...

journal_title：Neuroscience letters

authors： Taylor AR,Taylor SB,Koenig JI

更新日期：2012-12-07 00:00:00

abstract：:There is evidence suggesting that exposure to an abnormal magnetic environment may produce psychophysiological effects related to abnormalities in responses to stress. This may be of relevance for space medicine where astronauts are exposed to a magnetic field different from that exerted by the Earth. Aim of this stud...

journal_title：Neuroscience letters

authors： Del Seppia C,Mezzasalma L,Messerotti M,Cordelli A,Ghione S

更新日期：2006-06-12 00:00:00

abstract：:The possibility that single electrical shock stimulation of somatic afferent nerves could evoke a reflex response in vagal efferent nerves innervating the stomach was examined using anesthetized, artificially-ventilated rats. A single shock to a hindlimb afferent nerve (tibial nerve) produced two distinct reflex compo...

journal_title：Neuroscience letters

authors： Kimura A,Sato A,Sato Y,Suzuki A

更新日期：1996-05-24 00:00:00

abstract：:Topical application of horseradish peroxidase (HRP) to the ventral surface of the medulla oblongata revealed various cells with axons terminating near this region. Fibers traced from the ventral surface originated in the nucleus of the tractus solitarius and the dorsal nucleus of the vagus, both near the dorsal surfac...

journal_title：Neuroscience letters

authors： Errington ML,Dashwood MR

更新日期：1979-05-01 00:00:00

abstract：:Rabbit retinal Müller cells were isolated by means of papaine and mechanical dissociation. These cells were shown to have a well preserved morphology and to preserve viability for many hours. Intense wheat germ agglutinin binding occurs on the photoreceptor side of Müller cells, especially in the microvillous region. ...

journal_title：Neuroscience letters

authors： Reichenbach A,Dettmer D,Brückner G,Neumann M,Birkenmeyer G

更新日期：1985-03-22 00:00:00

abstract：:Pargyline, an inhibitor of monoamine oxidase (MAO), prevented 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced inhibition of dihydroxyphenylalanine (DOPA) production by tyrosine hydroxylase (TH) system in rat striatal tissue slices. The result suggests that the metabolism of MPTP in rat striatal tissue slic...

journal_title：Neuroscience letters

authors： Hirata Y,Nagatsu T

更新日期：1985-06-24 00:00:00

abstract：:Enteric glial cells are increasingly acknowledged as important partners of enteric neurons in the control of gastrointestinal function. They share morphological features and expression of antigenic markers with astrocytes of the central nervous system. Recently, aldehyde dehydrogenase 1 family member L1 (Aldh1L1) has ...

journal_title：Neuroscience letters

authors： Boesmans W,Rocha NP,Reis HJ,Holt M,Vanden Berghe P

更新日期：2014-04-30 00:00:00

abstract：:Aquaporin-1 (AQP1) is a water channel expressed in the choroid plexus and participates in forming cerebrospinal fluid. Interestingly, reactive astrocytes also express AQP1 in the central nervous system under some pathological conditions. On the other hand, 3-nitropropionic acid (3NP) is a mitochondrial toxin that caus...

journal_title：Neuroscience letters

authors： Hoshi A,Tsunoda A,Yamamoto T,Tada M,Kakita A,Ugawa Y

更新日期：2016-07-28 00:00:00

abstract：:Recent studies have demonstrated that cholesterol metabolism has an important role in Alzheimer's disease (AD) pathogenesis, suggesting that cholesterol-related genes may be significant genetic risk factors for AD. Based on the results of genome-wide screens, along with biological studies, we selected three genes as c...

journal_title：Neuroscience letters

authors： Shibata N,Kawarai T,Lee JH,Lee HS,Shibata E,Sato C,Liang Y,Duara R,Mayeux RP,St George-Hyslop PH,Rogaeva E

更新日期：2006-01-02 00:00:00

abstract：:In this study, the effects of 5-HT4 receptors of the CA1 on MK801-induced amnesia and hyperlocomotion were examined. One-trial step-down method was used to assess memory retention and then, the hole-board method to assess exploratory behaviors. The results showed that post-training intra-CA1 administration of RS67333 ...

journal_title：Neuroscience letters

authors： Nasehi M,Tabatabaie M,Khakpai F,Zarrindast MR

更新日期：2015-02-05 00:00:00

abstract：:In this study we reported evidence for the existence of specific binding sites for platelet-activating factor (PAF) in neuroblastoma N1E-115 cells. The specific [3H]PAF binding reached a steady state level within 60 min at 25 degrees C. Scatchard analysis of the specific [3H]PAF binding revealed the presence of two ap...

journal_title：Neuroscience letters

authors： Lalouette F,Diserbo M,Martin C,Verdetti J,Fatome M

更新日期：1995-02-17 00:00:00

abstract：:Three forms of stress-induced analgesia (electric shock, forced water-swim and novelty) were used to examine the nature of the endogenous antiopiate system. It was hypothesized that a role of the antiopiate system may be to regulate the extent of antinociception within varying environments. The antiopiate properties o...

journal_title：Neuroscience letters

authors： Galina ZH,Kastin AJ

更新日期：1988-02-03 00:00:00

abstract：:Imaging and lesion studies suggest that the cerebellum is involved in the self-generation of timed motor responses. Using repetitive transcranial magnetic stimulation (rTMS), we studied the effects of transient disruption of the lateral or medial cerebellum on a paced-finger-tapping task (PFT). Results show greater va...

journal_title：Neuroscience letters

authors： Théoret H,Haque J,Pascual-Leone A

更新日期：2001-06-22 00:00:00

abstract：:Molecular mechanisms regulating positions of oligodendrocyte precursor cells (OPCs) remain unclear in developing cerebral cortex. To explore the mechanisms, we investigated how Plexin-A4, receptor of Semaphorin in OPCs, is involved in the positioning. We found that Plexin-A4 knockout mice exhibited (1) an increased nu...

journal_title：Neuroscience letters

authors： Okada A,Tomooka Y

更新日期：2012-05-16 00:00:00

abstract：:In the rat, electrical stimulation of the cranial end of the cut hepatic branch of the vagus nerve modulated gastric contractions. When the gastric contraction rate reached approximately one per min, nerve stimulation caused total suppression. When the stomach was free of contraction, nerve stimulation initiated one. ...

journal_title：Neuroscience letters

authors： Lee KC

更新日期：1985-01-07 00:00:00

abstract：:Methamphetamine (METH) is a well-known drug of abuse and neurotoxin that may cause temporary or permanent disturbances in the dopaminergic systems of the brain, predisposing individuals to Parkinsonism. Previously, we have shown that METH causes dopaminergic cell death by increasing the production of reactive oxygen s...

journal_title：Neuroscience letters

authors： Ajjimaporn A,Phansuwan-Pujito P,Ebadi M,Govitrapong P

更新日期：2007-05-23 00:00:00

abstract：:The thickness of the dura mater was obtained from ultrasound probes on the skull and fast Fourier transform-Cepstrum through a probability process at various intracranial pressures (ICP), measured with pressure transducers, in 12 anesthetized dogs. There was a constant relationship between changes in thickness (micron...

journal_title：Neuroscience letters

authors： Kuchiwaki H,Inao S,Ishii N,Ogura Y,Sakuma N

更新日期：1995-09-22 00:00:00

abstract：:Idiopathic cervical dystonia (ICD) is a movement disorder often resulting in profound disability and pain. Treatment options include oral medications or other invasive procedures, whereas intractable ICD has been shown to respond to invasive (deep) brain stimulation. In the present blinded, placebo-controlled case stu...

journal_title：Neuroscience letters

authors： Angelakis E,Liouta E,Andreadis N,Leonardos A,Ktonas P,Stavrinou LC,Miranda PC,Mekonnen A,Sakas DE

更新日期：2013-01-15 00:00:00

abstract：:Pain is the most characteristic feature of sickle cell disease (SCD). Patients with SCD live with unpredictable, recurrent episodes of acute painful crisis, as well as chronic unremitting pain throughout their lifetime. While most of the research and medical efforts have focused on treating vaso-occlusion crisis and a...

journal_title：Neuroscience letters

authors： He Y,Wang ZJ

更新日期：2019-07-27 00:00:00

abstract：:MicroRNAs, such as miR-34, have been reported to influence age-related diseases. In this study, we explored the role of the miR-34a/Bcl-2 signaling pathway in age-related hearing loss (AHL). Using an AHL mouse model (C57BL/6), we found that the expression of miR-34a in the cochlea increased with age, whereas expressio...

journal_title：Neuroscience letters

authors： Huang Q,Zheng Y,Ou Y,Xiong H,Yang H,Zhang Z,Chen S,Ye Y

更新日期：2017-11-20 00:00:00

abstract：:We recently established adrenal medullary cell line tsAM5D, which was immortalized by use of a temperature-sensitive mutant of the oncogene simian virus 40 large T-antigen. In the present study, when co-treated with glial cell line-derived neurotrophic factor (GDNF) and ciliary neurotrophic factor (CNTF), tsAM5D cells...

journal_title：Neuroscience letters

authors： Murata T,Koide N,Tsuboi M,Kohno S,Hikita K,Kaneda N

更新日期：2008-06-13 00:00:00

abstract：:Several studies have demonstrated that the human motor cortex is activated by the mere observation of actions performed by others. In the present study, we explored whether the perception of 'impoverished motion stimuli', such as shadow animations, is sufficient to activate motor areas. To do so, transcranial magnetic...

journal_title：Neuroscience letters

authors： Alaerts K,Van Aggelpoel T,Swinnen SP,Wenderoth N

更新日期：2009-09-25 00:00:00

abstract：:The breakdown in brain ionic homeostasis during energy deprivation (anoxic depolarization [AD]) is intimately linked to neuronal injury. We studied the role of one particular route of Na+ influx, voltage-sensitive Na+ channels, in the AD induced by O2 and/or glucose deprivation. We recorded extracellular Na+ concentra...

journal_title：Neuroscience letters

authors： Fung ML,Croning MD,Haddad GG

更新日期：1999-11-05 00:00:00

abstract：:N-Methyl-D-aspartate (NMDA, 500 ng/0.5 microliters), alpha-amino-3-hydroxy-5-methyl-4-isoxasole-propionic acid (AMPA, 1000 ng/0.5 microliters), or kainic acid (50 ng/0.5 microliters) injected into intermediate and caudal parts of the caudate-putamen induced contralateral head turns and rotations. Picrotoxin (250 ng/0....

journal_title：Neuroscience letters

authors： Ossowska K

更新日期：1995-12-29 00:00:00

abstract：:The present study was carried out to examine whether γ-aminobutyric acid (GABA) receptor mechanisms are involved in the release of serotonin (5-hydroxytryptamine, 5-HT) in the subfornical organ (SFO) using intracerebral microdialysis techniques. Perfusion with the GABA receptor antagonists as well as agonists was perf...

journal_title：Neuroscience letters

authors： Takahashi M,Nomura M,Tanaka J

更新日期：2016-09-06 00:00:00

abstract：:Activation of spinal astrocytes may contribute to neuropathic pain. Adjacent astrocytes can make direct communication through gap junctions formed by connexin 43 (Cx43) in the central nervous system. Yet, the role of spinal astroglial gap junctions in neuropathic pain is not fully understood. Since Cx43 is the connexi...

journal_title：Neuroscience letters

authors： Xu Q,Cheong YK,He SQ,Tiwari V,Liu J,Wang Y,Raja SN,Li J,Guan Y,Li W

更新日期：2014-04-30 00:00:00

abstract：:Olfactory bulb-protein tyrosine phosphatase (OB-PTP) is a receptor type PTPase dominantly expressed in olfactory bulb. Previously, we isolated and molecularly cloned a rat OB-PTP cDNA from an embryonal brain cDNA library. In the present study, we investigated its temporal and spatial gene expression by Northern blot a...

journal_title：Neuroscience letters

authors： Yahagi Y,Tagawa M,Tomoda T,Shirasawa T

更新日期：1996-06-21 00:00:00