Fast sodium action potentials are generated in the distal apical dendrites of rat hippocampal CA1 pyramidal cells.

Abstract:

:Intracellular recording techniques were used to monitor the evoked responses in hippocampal CA1 pyramidal cells following focal stimulation of the proximally and distally located apical dendritic synapses. The local anaesthetic, QX-314, when injected into individual cells, caused a complete time-dependent blockade of the proximal and then the distal action potentials at both threshold and suprathreshold levels of stimulation. This progressive blockade of proximal and distal voltage-dependent sodium channels suggests that sodium action potentials can be generated in the distal apical dendrites of CA1 pyramidal cells.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Colling SB,Wheal HV

doi

10.1016/0304-3940(94)90665-3

subject

Has Abstract

pub_date

1994-05-19 00:00:00

pages

73-96

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(94)90665-3

journal_volume

172

pub_type

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