Abstract:
:Central administration of C-type natriuretic peptide (CNP) affects various neuroendocrine systems. In the present study, we examined whether CNP acts directly on arginine-vasopressin (AVP) secretion from rat supraoptic nucleus (SON) neurons, using acute dissociated cell preparations. CNP inhibited the basal secretion of AVP in a dose-dependent manner (10(-11)-10(-6) M). A- type natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) also suppressed the basal secretion of AVP, however, the effects were two-orders of magnitude less potent than CNP. CNP also suppressed All-induced AVP secretion, however, the inhibitory effect of CNP was less than that of ANP or BNP. These findings suggest that CNP inhibits the basal secretion of AVP through natriuretic peptide receptor (NPR)-B and has a role in the body water and electrolyte homeostasis in the central nervous system.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Yamamoto S,Morimoto I,Yanagihara N,Kangawa K,Inenaga K,Eto S,Yamashita Hdoi
10.1016/s0304-3940(97)00431-xsubject
Has Abstractpub_date
1997-06-27 00:00:00pages
97-100issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(97)00431-Xjournal_volume
229pub_type
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