Changes in c-fos mRNA in the neonatal rat brain following hypoxic ischemia.

Abstract:

:We used quantitative in situ hybridization to study changes in the expression of c-fos following hypoxic-ischemia (H-I) in the neonatal rat brain. 7-day-old rat pups were subjected to a unilateral ligation of the common carotid artery followed by a 2 h 15 min hypoxic period (7.7% O2 in N2). This resulted in the expected ipsilateral infarction of cortex, lateral hippocampus, lateral-superior aspects of the striatum and the white matter of the corpus callosum. Brain damage was not seen in the contralateral hemisphere subjected only to hypoxia. c-fos mRNA levels increased in the contralateral hemisphere immediately after the hypoxia and had returned towards normal levels 2 h thereafter. In the ipsilateral hemisphere, the expression of c-fos was delayed but very marked at 2 h. Animals subjected only to hypoxia showed little or no increase in c-fos mRNA. Thus the earliest recorded increase in c-fos after hypoxic ischemia, which occurred on the non-ischemic, contralateral side, may represent a generalized response to a more localized insult.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Adén U,Bona E,Hagberg H,Fredholm BB

doi

10.1016/0304-3940(94)90495-2

subject

Has Abstract

pub_date

1994-10-24 00:00:00

pages

91-5

issue

2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(94)90495-2

journal_volume

180

pub_type

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