Prefrontal cortex regulates burst firing and transmitter release in rat mesolimbic dopamine neurons studied in vivo.

Abstract:

:The influence of the medial prefrontal cortex (PFC) on mesolimbic dopamine activity was studied with electrophysiological techniques and in vivo voltammetry in the chloral hydrate-anesthetized male rat. Glutamate injected into the PFC selectively increased burst firing of single dopamine cells in the ventral tegmental area and enhanced the release of dopamine from nerve terminals in the nucleus accumbens. PFC injection of the local anesthetic lidocaine produced the opposite effects on burst firing and terminal release. This selective modulation of the dynamic activity of mesolimbic dopamine neurons by the prefrontal cortex might be important in motivation, learning and schizophrenia.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Murase S,Grenhoff J,Chouvet G,Gonon FG,Svensson TH

doi

10.1016/0304-3940(93)90641-w

subject

Has Abstract

pub_date

1993-07-09 00:00:00

pages

53-6

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(93)90641-W

journal_volume

157

pub_type

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