Thienyl-GABA derivatives as specific baclofen agonists in the rat and cat spinal cord in vivo.

abstract：:The critical period for visual system development in rats normally peaks at postnatal three weeks and ends at postnatal five weeks. However, the change of short-term synaptic plasticity during this period has rarely been investigated. In the present study, we compared the short-term plasticity of visual cortical respo...

journal_title：Neuroscience letters

authors： Jia F,Wei H,Li X,Xie X,Zhou Y

更新日期：2006-05-01 00:00:00

abstract：:The presence of neuromelanic pigment in neurons of the rat substantia nigra (SN) is a matter of controversy. The presence of neuromelanin in the SN of 15--24-month-old rats was investigated by electron microscopy (EM) and the findings compared to the morphology and distribution of neuromelanin in SN of dogs. In the ra...

journal_title：Neuroscience letters

authors： DeMattei M,Levi AC,Fariello RG

更新日期：1986-12-03 00:00:00

abstract：:The goal of this paper is to study possible differences between the processing of inflectional vs. derivational morphology in Spanish word recognition using electrophysiological measures. A lexical decision task to target words preceded by morphological-related (or unrelated) primes was used. The orthographic and phon...

journal_title：Neuroscience letters

authors： Alvarez CJ,Urrutia M,Domínguez A,Sánchez-Casas R

更新日期：2011-02-18 00:00:00

abstract：:A characteristic of Parkinson's disease (PD) is the development of tremor within the 4-6Hz range. One method used to better understand pathological tremor is to compare the responses to tremor-type actions generated intentionally in healthy adults. This study was designed to investigate the similarities and difference...

journal_title：Neuroscience letters

authors： Morrison S,Cortes N,Newell KM,Silburn PA,Kerr G

更新日期：2013-02-08 00:00:00

abstract：:Functional neuroimaging data have shown that mental calculation involves fronto-parietal areas that are composed of different subsystems shared with other cognitive functions such as working memory and language. Event-related potential (ERP) analysis has also indicated sequential information changes during the calcula...

journal_title：Neuroscience letters

authors： Ku Y,Hong B,Gao X,Gao S

更新日期：2010-03-12 00:00:00

abstract：:The brain and nasal region of a fetal (124 days) female rhesus macaque (Macaca mulatta) were fixed in situ, decalcified, sectioned and treated for the immunocytochemical demonstration of LHRH. Immunoreactive neurons and fibers were found in expected sites and also in sites not reported to date in primates: there was a...

journal_title：Neuroscience letters

authors： Witkin JW

更新日期：1987-08-18 00:00:00

abstract：:Cocaine-induced modifications of glutamatergic synaptic transmission in the mesolimbic system play a key role in adaptations that promote addictive behaviors. In particular, the activation of ionotropic glutamate N-methyl-D-aspartate receptor (NMDAR) in the ventral tegmental area (VTA) is critical for both cocaine-ind...

journal_title：Neuroscience letters

authors： Schumann J,Matzner H,Michaeli A,Yaka R

更新日期：2009-09-18 00:00:00

abstract：:In the toad Xenopus laevis, the microtubular density of 3-microns myelinated fibres was assessed in peripheral nerves, dorsal and ventral roots, and dorsal and ventral funiculi of the spinal cord. In the roots, the axonal microtubular density was 6 microtubules/microns 2 and twice as much at the other sampling sites. ...

journal_title：Neuroscience letters

authors： Saitua F,Alvarez J

更新日期：1989-10-09 00:00:00

abstract：:The origin of nerve fibers projecting to the guinea pig heart that contain nitric oxide synthase (NOS) were studied by unilateral cervical vagotomy. Three kinds of NOS-immunoreactive (NOS-ir) nerve fibers are distributed in the control guinea pig heart: the sparse network covering the right atrium, the basket-like end...

journal_title：Neuroscience letters

authors： Tanaka K,Chiba T

更新日期：1998-08-14 00:00:00

abstract：:Cerebral perfusion is important in older adults as it is linked to cognitive declines. Physical activity can improve blood flow in the body but little is known about the relationship between physical activity and cerebral perfusion in older adults. In particular, no study has investigated the relation between strength...

journal_title：Neuroscience letters

authors： Xu X,Jerskey BA,Cote DM,Walsh EG,Hassenstab JJ,Ladino ME,Clark US,Labbe DR,Gunstad JJ,Poppas A,Cohen RA,Hoge RD,Sweet LH

更新日期：2014-02-07 00:00:00

abstract：:Glutamic acid (Glu) participates in pain modulation of the central nervous system. The CA3 region of the hippocampal formation has been suggested to be involved in nociceptive perception. However, it is unknown whether Glu could modulate the electrical activities of pain-related neurons in the hippocampal CA3 region. ...

journal_title：Neuroscience letters

authors： Ma X,Shi TF,Zhang M,Lu XY,Yang CX,Zhu D,Shi DX,Yang Y,Wang CL,Zhang S,Xu MY

更新日期：2012-03-28 00:00:00

abstract：:Dysregulated brain glucose metabolism and lactate accumulation are seen following traumatic brain injury (TBI). The underlying molecular mechanism is poorly understood. Pyruvate dehydrogenase (PDH), the rate-limiting enzyme coupling cytosolic glycolysis to mitochondrial citric acid cycle, plays a critical role in main...

journal_title：Neuroscience letters

authors： Xing G,Ren M,Watson WD,O'Neill JT,Verma A

更新日期：2009-04-17 00:00:00

abstract：:The psychostimulant amphetamine (AMPH) is known to act as an indirect dopamine agonist by promoting dopamine release. Here we demonstrate direct AMPH inhibition of field potentials and Na+ currents in rat nucleus accumbens (NAc) neurons. The experiments were done with field potential recordings from NAc slices and who...

journal_title：Neuroscience letters

authors： Huang RC,Lin JY

更新日期：1998-08-07 00:00:00

abstract：:The presence of a novel member of serine proteinase inhibitor, B-43, was immunohistochemically indicated in both neurons and astrocytes in the parietal region of the bovine brain. B-43-like immunoreactivity was detected in pyramidal cells in the cortex and GFAP-positive astroglial cells in the white matter. The proces...

journal_title：Neuroscience letters

authors： Nishibori M,Ohtsuka A,Kawabata M,Nakaya N,Murakami T,Saeki K

更新日期：1995-11-17 00:00:00

abstract：:Interactions between subtypes of dopamine, glutamate and adenosine receptors seem to play an important integrative role in the function of striatal gamma-aminobutyric acid (GABA)ergic efferent neurons. Recent behavioral and biochemical studies suggest the existence of specific interactions between adenosine A2A recept...

journal_title：Neuroscience letters

authors： Díaz-Cabiale Z,Vivó M,Del Arco A,O'Connor WT,Harte MK,Müller CE,Martínez E,Popoli P,Fuxe K,Ferré S

更新日期：2002-05-17 00:00:00

abstract：:Bisphenol-A (BPA), a toxic chemical from polycarbonate plastics, is known for behavioural and neural abnormalities. These neuro-behavioural changes reflect the changes in neural activity. However the effect of BPA on nerve action potential is not available. Therefore, present investigation was undertaken to study the ...

journal_title：Neuroscience letters

authors： Pandey AK,Deshpande SB

更新日期：2012-05-31 00:00:00

abstract：:The primary component of amyloid deposits found in the brains of patients with Alzheimer's disease is the beta-amyloid protein, a derivative of a much larger precursor protein (beta PP). We have previously reported that overexpression of carboxyl (COOH)-terminal fragments of beta PP from an integrated DNA construct le...

journal_title：Neuroscience letters

authors： Fukuchi K,Sopher B,Furlong CE,Smith AC,Dang N,Martin GM

更新日期：1993-05-14 00:00:00

abstract：:Based on its proposed ability to block the effect of selective serotonin reuptake inhibitors (SSRIs) on the firing rate of serotonergic neurons, the 5-HT1A partial agonist/beta-adrenergic antagonist pindolol has been examined in clinical trials for its ability to enhance the efficacy of SSRIs. However, varying results...

journal_title：Neuroscience letters

authors： Rasmussen K,McCreary AC,Shanks EA

更新日期：2004-01-23 00:00:00

abstract：:Influences of a submaximal endurance test in the right first dorsal interosseus on force and fatigue-related parameters of activating the contralateral muscle were studied. The test consisted of a 30% maximum voluntary contraction (MVC), regularly interrupted by maximal contractions and brief rest periods. Despite the...

journal_title：Neuroscience letters

authors： Zijdewind I,Zwarts MJ,Kernell D

更新日期：1998-08-28 00:00:00

abstract：:The voltage dependency of the ON and the OFF components of transient amacrine cell responses was studied using two-electrode voltage-clamp and current-clamp techniques in the isolated retina of the carp. The two independent approaches gave similar data. When cells were voltage clamped near their resting potentials, bo...

journal_title：Neuroscience letters

authors： Djamgoz MB,Low JC,Saito T,Toyoda JI,Yamada M

更新日期：1996-08-23 00:00:00

abstract：:The distribution of cholecystokinin binding sites was studied by receptor autoradiography in the human striatum at midgestation, birth and adulthood. In the adult, cholecystokinin receptors are inhomogeneously distributed with patches of reduced labeling. In the caudate nucleus but not in the putamen these patches mat...

journal_title：Neuroscience letters

authors： Schiffmann SN,Goldman S,Heyman P,De Vuyst M,De Roy G,Vanderhaeghen JJ

更新日期：1992-07-06 00:00:00

abstract：:Sphingosine-1-phosphate (S1P) has been demonstrated to be an important regulator of cell death and survival. Although it has been suggested that the sphingolipid may act as a neuroprotector in the cell apoptosis induced by traumatic brain injury, the mechanisms involved in this action are unknown. In this study, the r...

journal_title：Neuroscience letters

authors： Agudo-López A,Miguel BG,Fernández I,Martínez AM

更新日期：2010-02-12 00:00:00

abstract：:The influence of transient forebrain ischemia on the temporal alteration of NMDA receptor (NMDAR1) mRNAs in the hippocampal formation was analysed by in situ hybridization, RNA blot and in vitro receptor autoradiography ([3H]3-((+)2-carboxypiperazin-4-yl)-propyl-1- phosphonic acid). In the CA1 subfield of the hippocam...

journal_title：Neuroscience letters

authors： Sugimoto A,Takeda A,Kogure K,Onodera H

更新日期：1994-03-28 00:00:00

abstract：:This study investigates whether potassium ion (K+) channels are involved in the nitric oxide (NO)-induced relaxation in segments of the isolated rat basilar artery, mounted onto a wire myograph. A high extracellular K+ concentration partly inhibited the relaxant effects of the NO donors DEA/NO and SIN-1 (3-morpholino-...

journal_title：Neuroscience letters

authors： Hempelmann RG,Seebeck J,Kruse ML,Ziegler A,Mehdorn HM

更新日期：2001-11-02 00:00:00

abstract：:Alzheimer's disease (AD) is still difficult to be precisely diagnosed in its early stage to date. Establishing of reliable and manageable disease-specific biological markers is required to improve diagnostic accuracy. Based on the hypothesis of cell cycle regulatory failure at the early stage of AD, we tested whether ...

journal_title：Neuroscience letters

authors： Tan M,Wang S,Song J,Jia J

更新日期：2012-05-16 00:00:00

abstract：:Studies of cognitive behavior in rodent models of Alzheimer's disease (AD) are the mainstay of academic and industrial efforts to find effective treatments for this disorder. However, in the majority of such studies, the nature of rodent behavioral tests is considerably different from the setting associated with cogni...

journal_title：Neuroscience letters

authors： Piiponniemi TO,Bragge T,Vauhkonen EE,Vartiainen P,Puoliväli JT,Sweeney PJ,Kopanitsa MV

更新日期：2017-05-22 00:00:00

abstract：:Methylphenidate (MPH) is a dopamine and norepinephrine reuptake inhibitor that is widely used for the treatment of attention-deficit/hyperactivity disorder in children and adults. Its similarity to other psychostimulants suggests that, at certain doses, the drug may generate lasting neuroadaptations that can be detrim...

journal_title：Neuroscience letters

authors： Taukulis HK,Bigney EE,Fry MD,Hooper C

更新日期：2014-04-30 00:00:00

abstract：:We have examined the effect of ouabain, a Na,K-ATPase inhibitor known to secondarily increase intracellular Ca2+ levels, on evoked (phasic) transmitter release at the frog neuromuscular junction. As had been reported previously, we observed an increase in both spontaneous and evoked release with prolonged exposure to ...

journal_title：Neuroscience letters

authors： Mosier DR,Zengel JE

更新日期：1994-06-06 00:00:00

abstract：:Evidence suggests that nitric oxide (NO) may mediate, at least in part, excitotoxic effects of excessive N-methyl-D-aspartate (NMDA) receptor activation both in vivo and in vitro. In the present experiments, NMDA-induced excitotoxicity has been studied in CHP100 neuroblastoma cell cultures. Application of NMDA (0.25-1...

journal_title：Neuroscience letters

authors： Corasaniti MT,Tartaglia RL,Melino G,Nisticò G,Finazzi-Agrò A

更新日期：1992-12-07 00:00:00

abstract：:l-Carnosine (β-alanyl-l-histidine), a dipeptide of the amino acids β-alanine and histidine, is found in mammalian tissues including those in the central nervous system and in skeletal muscles. In the present study, we examined the effects of intraduodenal (ID) injection of l-carnosine on splenic sympathetic nerve acti...

journal_title：Neuroscience letters

authors： Horii Y,Shen J,Fujisaki Y,Yoshida K,Nagai K

更新日期：2012-02-21 00:00:00