Voltage- and use-dependent inhibition by amphetamine of field potentials and Na+ current in rat nucleus accumbens neurons.

abstract：:In order to study the mechanism of intracellular sorting and processing of the Alzheimer's disease amyloid precursor protein (APP), we deleted two potential N-linked glycosylation sites of APP by site-directed mutagenesis. Substitution of alanines for the critical asparagine residues Asn467 and Asn496 was performed. W...

journal_title：Neuroscience letters

authors： Yazaki M,Tagawa K,Maruyama K,Sorimachi H,Tsuchiya T,Ishiura S,Suzuki K

更新日期：1996-12-27 00:00:00

abstract：:Exercise increases the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus and beneficially contributes to cognitive function and is accompanied by epigenetic changes. Specifically, the activity levels of histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate histone acetylat...

journal_title：Neuroscience letters

authors： Li X,Inoue T,Hayashi M,Maejima H

更新日期：2019-07-27 00:00:00

abstract：:The modulation of cutaneomuscular responses in response to mechanical vibration applied to the foot sole and to the ankle tendons was established in ten healthy subjects. The effects of mechanical vibration applied to the skin adjacent to the tibialis anterior (TA) and Achilles tendons were examined in two subjects. W...

journal_title：Neuroscience letters

authors： Smith AC,Mummidisetty CK,Rymer WZ,Knikou M

更新日期：2013-06-17 00:00:00

abstract：:Parkinson's disease (PD) etiology has been attributed both to genetic and environmental factors, although the exact mechanisms of its pathogenesis remains elusive. We investigated Brazilian early-onset PD (EOPD) patients with PINK1 polymorphisms (SNPs) in order to find possible correlations between SNPs, environmental...

journal_title：Neuroscience letters

authors： Godeiro C Jr,Aguiar PM,Felício AC,Barsottini OG,Silva SM,Borges V,Andrade LA,Ferraz HB

更新日期：2010-01-18 00:00:00

abstract：:Hemispheric asymmetries in spatial processing are generally considered to be responsible for the shorter reaction time (RT) of the left hand classically observed for right-handers when pointing at targets. Surprisingly, despite the special role which the right cerebral hemisphere is known to play in visual attention, ...

journal_title：Neuroscience letters

authors： Barthelemy S,Boulinguez P

更新日期：2001-11-23 00:00:00

abstract：:Strychnine-sensitive glycine-activated currents and gamma-aminobutyric acid (GABA)-activated currents were compared in two types of neurons acutely isolated from striatal slices by vibrodissociation: large cells, presumably cholinergic giant aspiny neurons (GAN) and medium sized cells, presumed medium spiny neurons (M...

journal_title：Neuroscience letters

authors： Sergeeva OA

更新日期：1998-02-27 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) has strong neurotrophic effects both in vivo and in vitro on various brain neurons. bFGF enhanced the branching of laser beam-damaged axons of primary cultured hippocampal neurons with a suppression of the neurite's re-elongation. Conditioned medium prepared from astrocytes, on th...

journal_title：Neuroscience letters

authors： Miyagawa T,Saito H,Nishiyama N

更新日期：1993-04-16 00:00:00

abstract：:It has been reported that tyrosine administration augments clozapine-induced dopamine (DA) release in the medial prefrontal cortex (MPFC). To characterize this effect and exclude possible confounds, we conducted a series of studies in which microdialysate collection started 24 h after probe implantation, a time at whi...

journal_title：Neuroscience letters

authors： Jaskiw GE,Simpson C,Bongiovanni R,Yamamoto BK

更新日期：2004-02-26 00:00:00

abstract：:Recently we have demonstrated the presence of a gap in the avian retinotectal projection, that corresponds with the locus of retinotopic representation of the elongated optic nerve head. The present report describes an equivalent gap in the optic neuropiles of the avian ventral geniculate nucleus and griseum tectalis ...

journal_title：Neuroscience letters

authors： Puelles L,Martinez S,Martinez-de-la-Torre M

更新日期：1988-02-15 00:00:00

abstract：:Carvedilol's potent antioxidant activity could explain its protective action in brain ischemia, but may not apply to glutamate-induced excitotoxicity in cultured cerebellar granule cells, since glutamate neurotoxicity was not associated with the formation of lipid peroxidative products. Rather, carvedilol diminished t...

journal_title：Neuroscience letters

authors： Lysko PG,Lysko KA,Webb CL,Feuerstein G

更新日期：1992-12-14 00:00:00

abstract：:A high expression of PrP(C) in cells is one factor that increases the risk of conversion to the misfolded, disease-associated form (PrP(Sc)) characteristic of transmissible spongiform encephalopathies. Thus, developing a method to control the level of PrP(C) expression in cells could be one way to delay or prevent the...

journal_title：Neuroscience letters

authors： Zawlik I,Witusik M,Hulas-Bigoszewska K,Piaskowski S,Szybka M,Golanska E,Liberski PP,Rieske P

更新日期：2006-05-29 00:00:00

abstract：:Behavioral responses and neural responses in the somatosensory cortex were recorded in nine rabbits during the unpaired and paired treatments of classical eyeblink conditioning with a tone conditioned stimulus (CS) and an airpuff unconditioned stimulus. During the unpaired treatment, neither the behavioral nor neural ...

journal_title：Neuroscience letters

authors： Wikgren J,Ruusuvirta T,Korhonen T

更新日期：2003-05-01 00:00:00

abstract：:Despite much study since its discovery in 1995, the effects of orphanin FQ/nociceptin (OFQ/N), the endogenous ligand of the 'orphan' opioid receptor, on nociceptive sensitivity remain unclear. Different laboratories have variously reported hyperalgesic, analgesic, anti-analgesic or no effect of the peptide on thermal ...

journal_title：Neuroscience letters

authors： Mogil JS,Nessim LA,Wilson SG

更新日期：1999-02-19 00:00:00

abstract：:Three variations of the in vitro neonatal rat spinal cord preparation were used to investigate motor responses to stimulation of the ventrolateral funiculus (VLF). In a partially hemisected spinal cord preparation, stimuli elicited frequency-dependent activity in lumbar ventral roots that outlasted the stimulus train ...

journal_title：Neuroscience letters

authors： Magnuson DS,Schramm MJ,MacLean JN

更新日期：1995-06-09 00:00:00

abstract：:The entorhinal cortex (EC) is an essential relay station in neocortical - hippocampal information transfer and memory functions. Layer II stellate and layer III pyramidal neurons show specific damage in Alzheimer's disease and epilepsy, respectively. Using whole cell patch clamp recording in rat brain slices we here d...

journal_title：Neuroscience letters

authors： Visan V,Heinemann U,Volynets A,Müller W

更新日期：2002-07-26 00:00:00

abstract：INTRODUCTION:Quantitative sensory testing (QST) is widely used in human research to investigate the integrity of the sensory function in patients with pain of neuropathic origin, or other causes such as low back pain. Reliability of QST has been evaluated on both sides of the face, hands and feet as well as on the trun...

journal_title：Neuroscience letters

authors： Knutti IA,Suter MR,Opsommer E

更新日期：2014-09-05 00:00:00

abstract：:The effect of nitric oxide donor compounds (sodium nitroprusside, hydroxylamine and S-nitroso-N-acetyl-D,L-penicillamine) on depolarization-induced release of endogenous dopamine in the light-adapted, isolated retina of the rabbit was studied by HPLC. All three compounds had the same effect, reducing the amount of dop...

journal_title：Neuroscience letters

authors： Djamgoz MB,Cunningham JR,Davenport SL,Neal MJ

更新日期：1995-09-22 00:00:00

abstract：:The existence of neurons expressing preprogalanin mRNA in the monkey hippocampal formation was demonstrated using in situ hybridization of a radio-labelled cRNA probe transcribed from human preprogalanin cDNA. Specific hybridization occurred in neurons of the hilus of the dentate gyrus, fields CA1-3 in Ammon's horn, s...

journal_title：Neuroscience letters

authors： Evans HF,Huntley GW,Morrison JH,Shine J,Paxinos G

更新日期：1992-11-09 00:00:00

abstract：:This investigation was designed to determine the responses of neurons in the posterior group of nuclei (PO) to tooth pulp stimulation. Eighteen tooth pulp-driven (TPD) neurons were recorded in 9 cats anesthetized with nitrous oxide and halothane, 14 of them in the medial part (POM) and the remainder in the lateral par...

journal_title：Neuroscience letters

authors： Matsumoto N,Sato T,Sawano H,Tochinai A,Suzuki TA

更新日期：1988-11-11 00:00:00

abstract：:Telmisartan is known to block angiotensin (Ang) II type-1 receptors (AT(1)R), and also activate peroxisome proliferator-activated receptor gamma (PPARgamma) signaling. Recently, PPARgamma has been implicated as a regulator of cellular proliferation and inflammatory responses. In the present study, we investigated the ...

journal_title：Neuroscience letters

authors： Haraguchi T,Takasaki K,Naito T,Hayakawa K,Katsurabayashi S,Mishima K,Iwasaki K,Fujiwara M

更新日期：2009-10-30 00:00:00

abstract：:Electrical stimulation in the lateral midbrain reticular formation (LRF) inhibited the responses of spinal dorsal horn neurons to noxious (50 degrees C) skin heating. Systemic administration of naloxone (0.1-2 mg/kg) had no effect on inhibition produced by LRF stimulation in 10 units, while this inhibition was partial...

journal_title：Neuroscience letters

authors： Carstens E,Zimmermann M

更新日期：1980-12-01 00:00:00

abstract：:N-Acetylaspartylglutamate (NAAG) is a dipeptide, and has been demonstrated to be a putative neurotransmitter in the brain. We hereby report the toxicity of NAAG in sagittal slices of mouse brain, in vitro, which is prevented by both N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists. Incubation of mouse bra...

journal_title：Neuroscience letters

authors： Pai KS,Ravindranath V

更新日期：1991-05-13 00:00:00

abstract：:Acetaldehyde (AcH) and salsolinol play important roles in the central effects of ethanol. This study aimed to investigate the effect of administration of AcH on dopamine (DA), DA-derived salsolinol and serotonin (5-HT) levels in the dorsal striatum of Aldh2-knockout (Aldh2-KO) and C57BL/6 N (WT) mice. Animals were tre...

journal_title：Neuroscience letters

authors： Ito A,Jamal M,Ameno K,Tanaka N,Takakura A,Kawamoto T,Kitagawa K,Nakayama K,Matsumoto A,Miki T,Kinoshita H

更新日期：2018-10-15 00:00:00

abstract：:In an in vitro preparation of the crayfish thoracic locomotor system, paired intracellular recordings were performed from antagonistic depressor (Dep) and levator (Lev) motoneurons (MNs) that control the second joint of walking legs. Connections between these two groups of MNs consist mainly of inhibitory connections ...

journal_title：Neuroscience letters

authors： Pearlstein E,Clarac F,Cattaert D

更新日期：1998-01-23 00:00:00

abstract：:The use of the cobalt technique is limited by the fact that cobaltous ions travel within axons for a shorter distance than do other intracellular markers. In the present experiments different organic cobaltous complexes were tested in the rat's sciatic nerve. Cobaltous complexes containing ornithine, threonine, lysine...

journal_title：Neuroscience letters

authors： Gallyas F,Lénárd L,Lázár G

更新日期：1978-09-01 00:00:00

abstract：:Hearing loss is a common sensory disorder that affects more than 360 million people worldwide, and is primarily caused by the loss of hair cells (HCs). Ototoxic drugs, viral infections, genetic predisposition, aging or noise all damage HCs. 3β-hydroxysteroid-Δ24 reductase (DHCR24), one enzyme in the cholesterol biosyn...

journal_title：Neuroscience letters

authors： Tian KY,Chang HM,Wang J,Qi MH,Wang WL,Qiu Y,Liang K,Chen FQ,Zha DJ,Qiu JH

更新日期：2019-07-27 00:00:00

abstract：:Stereotaxic microinjection of herpes simplex virus (HSV) into the mouse olfactory bulb resulted in infection of neurons of the piriform cortex. Neurons infected with the wildtype HSV showed no evident phosphorylation of c-Jun N-terminal protein kinase (JNK)/c-Jun. In contrast, neurons infected with a US3 gene-disrupte...

journal_title：Neuroscience letters

authors： Mori I,Goshima F,Koshizuka T,Koide N,Sugiyama T,Yoshida T,Yokochi T,Kimura Y,Nishiyama Y

更新日期：2003-11-20 00:00:00

abstract：:A growing body of evidence suggests that Alzheimer's disease (AD) is associated with local inflammation processes, including the activation of inflammatory cytokines. We performed a case-control association study between sporadic AD patients and the exon 5 position +3953 polymorphism in the potent pro-inflammatory cyt...

journal_title：Neuroscience letters

authors： Rosenmann H,Meiner Z,Dresner-Pollak R,Kahana E,Aladjem Z,Grenader T,Wertman E,Abramsky O

更新日期：2004-06-10 00:00:00

abstract：:Intellectual disability (ID) is one of the most prevalent chronic developmental brain disorders or phenotype of syndromic ID, affecting nearly 1-2% of the general population worldwide. Over recent decades, tremendous effort and high-throughput platforms have been devised to explore the complex heterogeneity, numerous ...

journal_title：Neuroscience letters

authors： Chen C,Chen D,Xue H,Liu X,Zhang T,Tang S,Li W,Xu X

更新日期：2018-10-15 00:00:00

abstract：:The simple cerebellar lobule is involved in several neuromotor processes and it is activated during guided exercise. Although guided exercises are essential for motor rehabilitation, the plastic events that occur in the simple cerebellar lobule during motor training remain unknown. In this study, normal adult rats wer...

journal_title：Neuroscience letters

authors： González-Burgos I,González-Tapia D,Zamora DA,Feria-Velasco A,Beas-Zárate C

更新日期：2011-03-24 00:00:00