Abstract:
:Interactions between subtypes of dopamine, glutamate and adenosine receptors seem to play an important integrative role in the function of striatal gamma-aminobutyric acid (GABA)ergic efferent neurons. Recent behavioral and biochemical studies suggest the existence of specific interactions between adenosine A2A receptors (A(2A)R), dopamine D2 receptors (D2R) and the group I metabotropic mGlu5 receptors (mGlu5R) in the dorsal striatum. The dual-probe approach in vivo microdialysis technique in freely moving rats was used to study the role of mGlu5R/A2AR/D2R interactions in the modulation of the ventral striopallidal GABA pathway. Perfusion of a selective mGlu5R agonist (CHPG) in the nucleus accumbens facilitated GABA release in the ipsilateral ventral pallidum. This effect was strongly potentiated by co-perfusion with the A2AR agonist CGS 21680. Co-perfusion with the D2R agonist quinpirole counteracted the increase in pallidal GABA levels induced by CGS 21680 and by CGS 21680 plus CHPG. These results demonstrate that mGlu5R/A2AR/D2R interactions play an important modulatory role in the function of the ventral striopallidal GABA pathway, which might have implications for the treatment of schizophrenia and drug addiction.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Díaz-Cabiale Z,Vivó M,Del Arco A,O'Connor WT,Harte MK,Müller CE,Martínez E,Popoli P,Fuxe K,Ferré Sdoi
10.1016/s0304-3940(02)00179-9keywords:
subject
Has Abstractpub_date
2002-05-17 00:00:00pages
154-8issue
2eissn
0304-3940issn
1872-7972pii
S0304394002001799journal_volume
324pub_type
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