Abstract:
:Intrinsically bursting (IB) neurons, responding with a burst of action potentials to just threshold intracellular depolarizing current pulses, are encountered in layer V of mature rodent sensorimotor cortex. We report the results of intracellular recordings performed on neocortical slices obtained from immature rats between postnatal day (P) 7 and P21, as compared to adult animals (above P60). The bursting properties are here reported to mature abruptly around P14. After this time a subpopulation of IB neurons was recognizable on the basis of both physiological and morphological characteristics (i.e. extensive apical and basal dendrites arborization, axon collaterals limited to layers V-VI). Maturational changes in number and distribution of Ca2+/K+ channels may account for this developmental step. The immaturity of IB neurons may be correlated with the poorly synchronized character of cortical activities in the very young animals.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Franceschetti S,Buzio S,Sancini G,Panzica F,Avanzini Gdoi
10.1016/0304-3940(93)90551-usubject
Has Abstractpub_date
1993-11-12 00:00:00pages
25-8issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(93)90551-Ujournal_volume
162pub_type
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