Tau gene polymorphisms and apolipoprotein E epsilon4 may interact to increase risk for Alzheimer's disease.

abstract：:In anesthetized cats selective activation of fine muscle afferents of the hindlimb by KCl or bradykinin (Brad.) induced reflex changes in the urinary bladder. The nature of the reflex responses depended on the functional state of the bladder: they were excitatory when the bladder was quiescent and inhibitory during la...

journal_title：Neuroscience letters

authors： Sato A,Sato Y,Schmidt PF

更新日期：1979-01-01 00:00:00

abstract：:In rats anesthetized with pentobarbital or a mixture of urethane and chloralose, horseradish peroxidase (HRP) was injected into the intermediolateral column of the spinal cord (Th7 and Th9) or the posterior pituitary lobe. HRP positive cells were found mainly in the dorsomedial part of the paraventricular nuclease (PV...

journal_title：Neuroscience letters

authors： Ono T,Nishino H,Sasaka K,Muramoto K,Yano I,Simpson A

更新日期：1978-11-01 00:00:00

abstract：:Conditioned environmental stimuli are known to be important determinants of drug seeking behavior. c-Fos, the protein product of the protooncogene c-Fos, is expressed in neurons when there are drug-associated cue-induced drug-seeking behaviour. Therefore, its expression could serve as a marker of regional neuronal act...

journal_title：Neuroscience letters

authors： Zhang F,Zhou W,Liu H,Zhu H,Tang S,Lai M,Yang G

更新日期：2005-09-30 00:00:00

abstract：:The high-affinity, sodium-dependent uptake of dopamine (DA) was inhibited by the pretreatment of synaptosomes with neuraminidase from Vibrio cholerae. The inhibition was of a non-competitive type, resulting in a 40% decrease of Vmax. Neither basal nor depolarization-stimulated release of DA was affected. Treatment of ...

journal_title：Neuroscience letters

authors： Zaleska MM,Erecińska M

更新日期：1987-11-10 00:00:00

abstract：:The dopaminergic system has a long history of being associated with reward-related activities but the developmental consequences of blocking dopamine receptor function on reward-based associative learning has been less studied. To this end, male, Long Evans rats were systemically (i.p.) treated with the dopamine recep...

journal_title：Neuroscience letters

authors： Holahan MR,Goheen K

更新日期：2020-04-23 00:00:00

abstract：:The bradykinin B2 receptor (B2R) mediates many physiological processes such as hypotension, inflammation and blood-vessel permeability. Hypoxia/reoxygenation (H/R) induces neuronal cell apoptosis. It was found that B2R expression was enhanced in primary cultured cortical neurons after H/R treatment. Addition of bradyk...

journal_title：Neuroscience letters

authors： Tang M,Cui M,Dong Q,Ren HM,Xiao BG,Luo BY,Shao Y,Liu L,Zhou HG

更新日期：2009-01-23 00:00:00

abstract：:Following various types of wounds and subsequent denervation, the reinnervation of the rabbit corneal epithelium was found to occur in two distinct phases that overlapped in time. In the first phase large numbers of collateral sprouts originated from the unmyelinated plexus at various distances proximal to the site of...

journal_title：Neuroscience letters

authors： Beuerman RW,Rózsa AJ

更新日期：1984-01-27 00:00:00

abstract：:We observed ontogenetic changes of neuropeptide Y (NPY)-like-immunoreactivity in the terminal nerve (TN) of the chum salmon, a teleost, and the cloudy dogfish, an elasmobranch. In the chum salmon, NPY-like-immunoreactive (NPY-IR) cells first appeared in the olfactory placode of embryos at 16 days after fertilization, ...

journal_title：Neuroscience letters

authors： Chiba A,Oka S,Honma Y

更新日期：1996-07-26 00:00:00

abstract：:In vivo electrochemistry was used to determine the effects of locally applied raclopride (a D2 receptor antagonist) and SCH-23390 (a D1 receptor antagonist) on the clearance of locally applied dopamine in the striatum, nucleus accumbens, and medial prefrontal cortex of rats. Chronoamperometric recordings were continuo...

journal_title：Neuroscience letters

authors： Cass WA,Gerhardt GA

更新日期：1994-08-01 00:00:00

abstract：:Based on its proposed ability to block the effect of selective serotonin reuptake inhibitors (SSRIs) on the firing rate of serotonergic neurons, the 5-HT1A partial agonist/beta-adrenergic antagonist pindolol has been examined in clinical trials for its ability to enhance the efficacy of SSRIs. However, varying results...

journal_title：Neuroscience letters

authors： Rasmussen K,McCreary AC,Shanks EA

更新日期：2004-01-23 00:00:00

abstract：:Acetylcholinesterase staining was examined in the substantia innominata of 3 normal human brains. Large intensely stained neurones were seen within the region of the basal nucleus of Meynert which is believed to be the origin of the cholinergic projection to the neocortex in animals. On the basis of the acetylcholines...

journal_title：Neuroscience letters

authors： Rossor MN,Svendsen C,Hunt SP,Mountjoy CQ,Roth M,Iversen LL

更新日期：1982-02-12 00:00:00

abstract：:Functionally active N-methyl-D-aspartate (NMDA) receptors on cat medullary respiratory neurones were revealed by local iontophoretic application of DL-2-amino-7-phosphonoheptanoic acid (AP7). Blockade of NMDA receptors by systemic administration of NMDA antagonists (MK-801, phencyclidine, ketamine, AP7) in vagotomized...

journal_title：Neuroscience letters

authors： Foutz AS,Champagnat J,Denavit-Saubié M

更新日期：1988-05-03 00:00:00

abstract：:The human craniofacial muscles innervated by the facial nerve typically lack muscle spindles. However these muscles have proprioception that participates in the coordination of facial movements. A functional substitution of facial proprioceptors by cutaneous mechanoreceptors has been proposed but at present this alter...

journal_title：Neuroscience letters

authors： Cobo JL,Abbate F,de Vicente JC,Cobo J,Vega JA

更新日期：2017-02-15 00:00:00

abstract：:A combination of immunocytochemistry with transmitter specific autoradiography at the electron microscopic level was used to identify vasoactive intestinal polypeptide (VIP)- or ACTH-containing neurons and serotoninergic nerve terminals in the suprachiasmatic (SCN) and arcuate nuclei (AN). We observed nerve terminals ...

journal_title：Neuroscience letters

authors： Kiss J,Léránth C,Halász B

更新日期：1984-02-10 00:00:00

abstract：:This study aims to investigate the relationship between DNA methylation and expression of human dopamine transporter (hDAT). We examined methylation status of hDAT in cells with various hDAT expression levels, including two dopaminergic neural cell lines (SK-N-AS and SH-SY-5Y) and one non-dopaminergic cell line (HEK29...

journal_title：Neuroscience letters

authors： Zhai D,Li S,Dong G,Zhou D,Yang Y,Wang X,Zhao Y,Yang Y,Lin Z

更新日期：2018-01-01 00:00:00

abstract：:The mechanism of sympathetic - sensory coupling after nerve injury is still not well understood. We have studied the changes in resting potential and excitability of sensory neurones induced by adrenergic stimulation, using whole-cell and perforated-patch recordings in cultured dorsal root ganglion neurones from norma...

journal_title：Neuroscience letters

authors： Pluteanu F,Ristoiu V,Flonta ML,Reid G

更新日期：2002-09-06 00:00:00

abstract：:The genetically heterozygous spinocerebellar ataxias are all characterized by cerebellar atrophy and pervasive Purkinje Cell degeneration. Up to date, more than 35 functionally diverse spinocerebellar ataxia genes have been identified. The main question that remains yet unsolved is why do some many genetic insults lea...

journal_title：Neuroscience letters

authors： Huang M,Verbeek DS

更新日期：2019-01-01 00:00:00

abstract：:Oxidative stress is considered important for the pathogenesis of Alzheimer disease (AD), which is characterized by the formation of senile plaques rich in amyloid beta-protein (Abeta). Abeta cytotoxicity has been found dependent on lysosomes, which are abundant in AD neurons and are shown to partially co-localize with...

journal_title：Neuroscience letters

authors： Zheng L,Roberg K,Jerhammar F,Marcusson J,Terman A

更新日期：2006-02-20 00:00:00

abstract：:The cardiovascular effects of intracerebroventricularly administered thyrotropin-releasing hormone (TRH) were studied in anesthetized rats in the presence of serotonin (5-HT) depletion induced by pretreatments with p-chloroamphetamine (PCA) or p-chlorophenylalanine (PCPA). After PCA the reduction of the whole brain 5-...

journal_title：Neuroscience letters

authors： Nurminen ML,Paakkari I,Seppälä T

更新日期：1991-06-24 00:00:00

abstract：:Human nerve growth factor (NGF) serum concentrations were measured in a healthy sample of 126 participants by a modified highly sensitive and specific two-site enzyme immunoassay. The measured NGF concentrations differ considerably from a normal distribution. The median NGF concentration was 19.68 pg/ml with an interq...

journal_title：Neuroscience letters

authors： Lang UE,Gallinat J,Danker-Hopfe H,Bajbouj M,Hellweg R

更新日期：2003-06-19 00:00:00

abstract：:The highest prevalence rate of spinocerebellar ataxia type 6 (SCA6) in the worldwide population is in the Chugoku and Kansai areas of Western Japan, but the reason of this geographic characteristics is unclear. We investigated the predisposing haplotypes and their geographic distribution. Genotyping of five microsatel...

journal_title：Neuroscience letters

authors： Terasawa H,Oda M,Morino H,Miyachi T,Izumi Y,Maruyama H,Matsumoto M,Kawakami H

更新日期：2004-03-25 00:00:00

abstract：:A retrograde tracer, Diamidino yellow, was injected into the hindlimb region of the supplementary motor area after intracortical microstimulation mapping in the Japanese monkey. As a result, a cluster of retrogradely labeled neurons was found in the caudal bank of the arcuate sulcus, which corresponds to the ventral p...

journal_title：Neuroscience letters

authors： Tokuno H,Inase M

更新日期：1994-04-25 00:00:00

abstract：:6-hydroxydopamine (6-OHDA) is usually thought to cross cell membrane through dopamine uptake transporters, to inhibit mitochondrial respiration and to generate intracellular reactive oxygen species. In this study, we show that the anti-oxidants catalase, glutathione and N-acetyl-cysteine are able to reverse the toxic ...

journal_title：Neuroscience letters

authors： Blum D,Torch S,Nissou MF,Benabid AL,Verna JM

更新日期：2000-04-14 00:00:00

abstract：:Immunoreactive beta-endorphin is localized mainly in the synaptosome-enriched subcellular fraction from rat hypothalami. In this report, we demonstrate that release of immunoreactive beta-endorphin from the synaptosome-enriched subcellular fraction is increased by 150% in a medium containing high potassium. This stimu...

journal_title：Neuroscience letters

authors： Fukata J,Nakai Y,Imura H

更新日期：1980-08-01 00:00:00

abstract：:The influence of testosterone on the postnatal development of reflex electromyographic (EMG) jaw muscle activity evoked by injection of mustard oil (MO) into the temporomandibular joint region and the later recurrence of this EMG activity after intravenous injection of naloxone, was studied in male rats. MO-evoked EMG...

journal_title：Neuroscience letters

authors： Seo K,Fujiwara N,Cairns BE,Someya G

更新日期：2002-12-25 00:00:00

abstract：:Previous studies have reported that intrahemispheric connections between area 17 (V1, striate cortex) and other cortical visual areas are not point-to-point, but instead have some degree of convergence and divergence. Many pathological conditions can interfere with the normal development of patterns of cortico-cortica...

journal_title：Neuroscience letters

authors： Bock AS,Olavarria JF

更新日期：2011-09-01 00:00:00

abstract：:Expression by rat motoneurons of mRNAs for the alpha subunit of the ciliary neurotrophic factor receptor (CNTFR alpha), receptor tyrosine kinase-C (trkC), calcitonin gene-related peptide (CGRP) and galanin was studied by in situ hybridisation, 6d after rat facial nerve transection on postnatal day 1. Similar numbers o...

journal_title：Neuroscience letters

authors： Duberley RM,Johnson IP

更新日期：1996-11-08 00:00:00

abstract：:Removal of glutamate from the synaptic cleft by astroglial glutamine synthase (GS) is a crucial step in the regulation of glutamate turnover and metabolism, thus participating in endogenous neuroprotective processes occurring within brain tissues. Here we investigated on the effect of inflammatory cytokines on GS acti...

journal_title：Neuroscience letters

authors： Muscoli C,Visalli V,Colica C,Nisticò R,Palma E,Costa N,Rotiroti D,Nisticò G,Mollace V

更新日期：2005-01-20 00:00:00

abstract：:Behavioral responses and neural responses in the somatosensory cortex were recorded in nine rabbits during the unpaired and paired treatments of classical eyeblink conditioning with a tone conditioned stimulus (CS) and an airpuff unconditioned stimulus. During the unpaired treatment, neither the behavioral nor neural ...

journal_title：Neuroscience letters

authors： Wikgren J,Ruusuvirta T,Korhonen T

更新日期：2003-05-01 00:00:00

abstract：:Alpha-2 macroglobulin (A2M) is a serum pan-protease inhibitor that is related with the pathogenesis of Alzheimer's disease (AD) through its ability to mediate amyloid beta degradation. Recently, it has been reported that the I1000V polymorphism in A2M gene might increase the risk of AD. In the present study, we invest...

journal_title：Neuroscience letters

authors： Shibata N,Ohnuma T,Takahashi T,Ohtsuka E,Ueki A,Nagao M,Arai H

更新日期：2000-08-25 00:00:00