Abstract:
:The mechanism of sympathetic - sensory coupling after nerve injury is still not well understood. We have studied the changes in resting potential and excitability of sensory neurones induced by adrenergic stimulation, using whole-cell and perforated-patch recordings in cultured dorsal root ganglion neurones from normal rats. Adrenaline (1-100 microM) depolarized 18 of 39 neurones (46%) and hyperpolarized seven neurones (18%); excitability was increased and decreased, respectively. Stimulating the neurones with 10 microM phenylephrine (alpha(1)-agonist) induced depolarization and increased excitability, while 10 microM isoprenaline (beta-agonist) induced hyperpolarization and reduced excitability. We conclude that alpha(1)- and beta-receptors have opposing effects on membrane potential and excitability in cultured dorsal root ganglion neurones, and the differing effects of adrenaline can be explained by different degrees of expression of each receptor type.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Pluteanu F,Ristoiu V,Flonta ML,Reid Gdoi
10.1016/s0304-3940(02)00665-1keywords:
subject
Has Abstractpub_date
2002-09-06 00:00:00pages
277-80issue
3eissn
0304-3940issn
1872-7972pii
S0304394002006651journal_volume
329pub_type
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