当前位置： SCI文献检索 > NEUROSCIENCE LETTERS期刊下所有文献 > Long-chain fatty acids increase cellular dopamine in an immortalized cell line (MN9D) derived from mouse mesencephalon.

Long-chain fatty acids increase cellular dopamine in an immortalized cell line (MN9D) derived from mouse mesencephalon.

Abstract：

:The lysate of an immortalized monoclonal cell line derived from the striatum (X61) contains a dopaminergic stimulatory activity that is capable of increasing the dopamine content of an immortalized mouse mesencephalic cell line (MN9D) which expresses a dopaminergic phenotype. Purification of an isoamyl alcohol extract of this lysate and subsequent identification by NMR spectroscopic analysis demonstrated that the dopaminergic stimulatory activity contained within the lysate was a mixture of 80-90% cis-9-octadecenoic acid (oleic acid) and 10-20% cis-11-octadecenoic acid (cis-vaccenic acid). The effect of oleic acid on MN9D dopamine is a prolonged event. MN9D dopamine increases linearly over a 48 h period suggesting the induction of an increased dopaminergic phenotype in these dividing cells. The ability to increase MN9D dopamine by oleic and cis-vaccenic acids is shared by a number of other long-chain fatty acids including arachidonic, linoleic, linolenic, palmitoleic, and cis-13-octadecenoic acid. The possibility that oleic or other relatively innocuous fatty acids might affect dopaminergic function in primary neurons is intriguing with respect to possible therapeutic approaches to the treatment of dopaminergic cell loss and the motor sequelae of Parkinson's disease.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Heller A,Won L,Bubula N,Hessefort S,Kurutz JW,Reddy GA,Gross M

doi

10.1016/j.neulet.2004.11.021

keywords:

subject

Has Abstract

pub_date

2005-03-07 00:00:00

pages

35-9

issue

1

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(04)01429-6

journal_volume

376

pub_type

杂志文章

相关文献

NEUROSCIENCE LETTERS文献大全
  • Enhanced axonal transport of receptor-bound opiate in ethanol-treated rats.

    abstract：:The retrograde transport of receptor-bound opiate was markedly enhanced in the vagus nerves of rats housed for 25 days in an atmosphere of ethanol vapor. This increase disappeared after 8 days of withdrawal as did the animal preference for ethanol. In contrast, the axonal transport of muscarinic receptors in sciatic n...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(87)90525-8

    authors： Laduron PM,De Witte PA

    更新日期：1987-06-26 00:00:00

  • The denervated hippocampus provides proper microenvironment for the survival and differentiation of neural progenitors.

    abstract：:The fate of neural stem/progenitor cells (NSCs/NPCs) in vivo lies on the local microenvironment. Whether the denervated hippocampus provides a stimulative role on the survival and differentiation of the anterior subventricular zone (SVZa) progenitors was investigated in the present study. In vivo the SVZa progenitors ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2006.07.078

    authors： Zhang X,Jin G,Tian M,Qin J,Huang Z

    更新日期：2007-03-06 00:00:00

  • Time-dependent plasticity of synaptic transmission produced by long-term potentiation of C-fiber evoked field potentials in rat spinal dorsal horn.

    abstract：:Our previous work has shown that repetitive stimulation of Adelta-fibers depresses long-term potentiation (LTP) of C-fiber evoked field potentials in spinal dorsal horn. Here, we tested the effects of the Adelta stimulation on the spinal LTP at different time points following LTP induction. Fifteen minutes after LTP i...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(01)02343-6

    authors： Zhang HM,Qi YJ,Xiang XY,Zhang T,Liu XG

    更新日期：2001-11-23 00:00:00

  • Epitope mapping and specificity of the anti-alpha-synuclein monoclonal antibody Syn-1 in mouse brain and cultured cell lines.

    abstract：:While alpha- and beta-synuclein largely overlap in their expression in the vertebrate brain, only alpha-synuclein accumulates in the fibrillar aggregates typical of Parkinson's disease. It is thus critical to have immunological reagents that distinguish between these two protein isoforms. The monoclonal antibody Syn-1...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(03)00781-x

    authors： Perrin RJ,Payton JE,Barnett DH,Wraight CL,Woods WS,Ye L,George JM

    更新日期：2003-10-02 00:00:00

  • Evaluation of oxidative stress and brain-derived neurotrophic factor levels related to crack-use detoxification.

    abstract：:Crack is a central nervous system stimulant extracted from the Erythroxylum coca plant. It is considered the most potent and addictive form of cocaine, and its euphoric effects are attained within a few seconds after consumption. Alteration of biological markers of oxidative stress and brain-derived neurotrophic facto...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2018.01.044

    authors： Hirsch GE,Jaskulski M,Hamerski HM,Porto FG,da Silva B,Aita CAM,Kroker K,de Bem Silveira G,Silveira PCL,Santos GT,Klafke JZ,Viecili PRN

    更新日期：2018-03-23 00:00:00

  • Human mesenchymal stem cells improve the neurodegeneration of femoral nerve in a diabetic foot ulceration rats.

    abstract：:Neuropathy is observed in 50% of diabetic patients with diabetic foot. This study attempted to explore the potential role of human mesenchymal stem cells-umbilical cord blood (hMSCs-UC) in femoral nerve (FN) neuropathy. The model rats were established by one time administration of streptozotocin and empyrosis on the d...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2015.04.038

    authors： Xia N,Xu JM,Zhao N,Zhao QS,Li M,Cheng ZF

    更新日期：2015-06-15 00:00:00

  • Manual reaction time asymmetries in human subjects: the role of movement planning and attention.

    abstract：:Hemispheric asymmetries in spatial processing are generally considered to be responsible for the shorter reaction time (RT) of the left hand classically observed for right-handers when pointing at targets. Surprisingly, despite the special role which the right cerebral hemisphere is known to play in visual attention, ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(01)02313-8

    authors： Barthelemy S,Boulinguez P

    更新日期：2001-11-23 00:00:00

  • C31 enhances voltage-gated calcium channel currents in undifferentiated PC12 cells.

    abstract：:C31, consisting of 31 amino acid residues, is generated from the carboxyl terminal fragments (CTFs) of amyloid precursor protein (APP). It has been shown that C31 causes apoptosis in neurons and is present in brains of Alzheimer disease (AD) patients. Using whole-cell patch clamp techniques, we investigated effects of...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2005.02.065

    authors： Ma ZG,Wang J,Jiang H,Xie JX,Chen L

    更新日期：2005-07-01 00:00:00

  • The focus of attention at the virtual cocktail party--electrophysiological evidence.

    abstract：:The width of the attentional focus during the selection of one of two concurrent normal human participants was investigated using event-related potentials. Two stories were presented from virtual locations located 15° to the left and right azimuth by convolving the speech message by the appropriate head-related transf...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2010.11.066

    authors： Lambrecht J,Spring DK,Münte TF

    更新日期：2011-02-01 00:00:00

  • NOC-9, a selective nitric oxide donor, induces flight reactions in the dorsolateral periaqueductal gray of rats by activating soluble guanylate cyclase.

    abstract：:Previous studies have showed that SIN-1, a nitric oxide (NO) donor, injected into the dorsolateral column of the periaqueductal gray (dlPAG) induces flight reactions. This drug, however, can also produce peroxynitrite, which may interfere in this effect. In addition, it is also unknown if this effect is mediated by lo...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2009.05.009

    authors： Braga AA,Aguiar DC,Guimarães FS

    更新日期：2009-08-07 00:00:00

  • The termination pattern of sciatic nerve afferents in the substantia gelatinosa of neonatal rats.

    abstract：:A study was carried out to determine at what stage of development the adult pattern of primary afferent projections to the substantia gelatinosa (SG) is first established. Horseradish peroxidase conjugated wheat-germ agglutinin (WGA-HRP) was applied to cut ends of sciatic nerves at mid-thigh level in adult and neonata...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(83)90179-9

    authors： Fitzgerald M,Swett J

    更新日期：1983-12-30 00:00:00

  • Hypoxia and reoxygenation increased BACE1 mRNA and protein levels in human neuroblastoma SH-SY5Y cells.

    abstract：:Ischemic cerebrovascular diseases, usually involved in hypoxia and reoxygenation, have been reported to increase the risk of dementia such as Alzheimer's disease (AD). beta-site amyloid protein precursor (APP)-cleaving enzymes (BACE1) have been identified to participate in the secretion of beta-amyloid peptides (Abeta...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2006.07.013

    authors： Xue S,Jia L,Jia J

    更新日期：2006-09-25 00:00:00

  • Reduced effects of amphetamine on prepulse inhibition of startle in gastrin-deficient mice.

    abstract：:The present study was aimed at investigating the role of gastrin in startle, startle habituation and prepulse inhibition (PPI). There were no significant differences between gastrin knockout mice and their wildtype controls in any of these baseline parameters. The disruption of PPI by treatment with 5 mg/kg of ampheta...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2004.10.013

    authors： van den Buuse M,van Driel IR,Samuelson LC,Pijnappel M,Martin S

    更新日期：2005-01-20 00:00:00

  • Topographical distribution of pinprick and warmth thresholds to CO2 laser stimulation on the human skin.

    abstract：:We studied the topographical distribution of laser sensory thresholds on the human hairy skin, using a small laser beam for pinprick and a large beam for warmth sensations. The threshold for pinprick sensation correlated positively with the distance from the brain, suggesting that Adelta nociceptors, the fibers which ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(00)01038-7

    authors： Agostino R,Cruccu G,Iannetti G,Romaniello A,Truini A,Manfredi M

    更新日期：2000-05-12 00:00:00

  • Pertussis toxin blocks a late inhibitory postsynaptic potential in hippocampal CA3 neurons.

    abstract：:These experiments show that a synaptic response, namely the late inhibitory postsynaptic potential (IPSP) of hippocampal CA3 neurons of rats, is blocked by pertussis toxin, an inactivator of several GTP-binding proteins (G-proteins) excluding the G-protein that stimulates adenylyl cyclase. This blockage occurred witho...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(87)90168-6

    authors： Thalmann RH

    更新日期：1987-11-10 00:00:00

  • Chlorpromazine prolongs the deactivation of N-methyl-D-aspartate-induced currents in cultured rat hippocampal neurons.

    abstract：:The effect of chlorpromazine (CPZ) on deactivation of N-methyl-D-aspartate (NMDA)-induced currents was studied in the whole-cell configuration of the patch-clamp technique in cultured rat hippocampal neurons. We report that CPZ (at 30-1000 microM) strongly slowed down the deactivation process in a dose-dependent manne...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(01)02245-5

    authors： Zarnowska ED,Mozrzymas JW

    更新日期：2001-11-23 00:00:00

  • Abnormal distribution of phosphorylated neurofilaments in neuronal degeneration induced by kainic acid.

    abstract：:An abnormal distribution of phosphorylated neurofilaments is present in some human neurodegenerative disorders including Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis. This study reports the changes of phosphorylated neurofilaments observed in rat spinal cord after intrathecal injection o...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(90)90751-t

    authors： Hugon J,Vallat JM

    更新日期：1990-10-30 00:00:00

  • Fingolimod administration improves neurological functions of mice with subarachnoid hemorrhage.

    abstract：PURPOSE:To investigate the brain protective effects of fingolimod on inflammatory response of SAH mice. METHODS:We utilized an endovascular mouse perforation model of SAH. Mice were divided into three groups: sham group, SAH group and SAH + Fingolimod group. Mice received either saline or fingolimod (1 mg/kg) intraper...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2020.135250

    authors： Wang Y,Zhou S,Han Z,Yin D,Luo Y,Tian Y,Wang Z,Zhang J

    更新日期：2020-09-25 00:00:00

  • The involvement of L-type calcium channels in heterosynaptic long-term depression in the hippocampus.

    abstract：:The involvement of L-type calcium channels in heterosynaptic long-term depression (LTD) of the stratum radiatum input to area CA1 was studied in rat hippocampal slices. LTD of the radiatum field excitatory postsynaptic potential (EPSP) and population spike, produced by tetanization of the alveus in the presence of pic...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(91)90244-n

    authors： Wickens JR,Abraham WC

    更新日期：1991-09-02 00:00:00

  • Corticospinal circuit plasticity in motor rehabilitation from spinal cord injury.

    abstract：:Restoring corticospinal function after spinal cord injury is a significant challenge as the corticospinal tract elicits no substantive, spontaneous regeneration, and its interruption leaves a permanent deficit. The corticospinal circuit serves multiple motor and sensory functions within the mammalian nervous system as...

    journal_title：Neuroscience letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.neulet.2016.12.003

    authors： Serradj N,Agger SF,Hollis ER 2nd

    更新日期：2017-06-23 00:00:00

  • The influence of cerebrospinal fluid turnover on age-related changes in cerebrospinal fluid protein concentrations.

    abstract：:Studies have shown that ageing and several neurological diseases of the central nervous system are often accompanied with increase in concentrations of many cerebrospinal fluid (CSF) proteins. However, few studies have actually looked into the mechanisms behind the increase in CSF protein concentrations. In this study...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2010.04.015

    authors： Chen CP,Chen RL,Preston JE

    更新日期：2010-06-07 00:00:00

  • Metabolomic analysis to detect urinary molecular changes associated with bipolar depression.

    abstract：:Bipolar disorder (BD) is a debilitating mental disorder with complex clinical manifestations and low diagnostic accuracy. Depressive episodes are most common in the course of BD with high comorbidity and suicide rates, which present greater clinical challenges than mania and hypomania episodes. However, there are no o...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2020.135515

    authors： Ren Y,Chen ZZ,Sun XL,Duan HJ,Tian JS,Wang JY,Yang H

    更新日期：2021-01-18 00:00:00

  • Modulation of the human glucocorticoid receptor function by antidepressive compounds.

    abstract：:Hyperactivity of the hypothalamic-pituitary-adrenal axis is associated with depression. We investigated the effect of various types of antidepressant agents in vitro on the function of glucocorticoid receptor (GR). Desipramine, clomiplamine, fluoxetine, milnacipran and clorgyline all induced rapid and sustained transl...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(03)00261-1

    authors： Okuyama-Tamura M,Mikuni M,Kojima I

    更新日期：2003-05-22 00:00:00

  • Differential time course and intensity of PFC activation for men and women in response to emotional stimuli: a functional near-infrared spectroscopy (fNIRS) study.

    abstract：:Using functional near-infrared spectroscopy (fNIRS) we recorded prefrontal cortex (PFC) activation during positive, negative and neutral film clips, based on affective ratings according to their valence and arousal, to assess gender differences in cerebral activation in 15 male and 15 female volunteers. To record PFC ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2006.04.050

    authors： Leon-Carrion J,Damas J,Izzetoglu K,Pourrezai K,Martín-Rodríguez JF,Barroso y Martin JM,Dominguez-Morales MR

    更新日期：2006-07-31 00:00:00

  • Effect of baicalein from Scutellaria baicalensis on prevention of noise-induced hearing loss.

    abstract：:Noise-induced hearing loss (NIHL) has been thought to primarily involve damage to the sensory hair cells of the cochlea via mechanical and metabolic mechanisms. This study examined the effects of baicalin, baicalein, and Scutellaria baicalensis (SB) extract against NIHL in a mouse model. Mice received oral treatment w...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2009.12.009

    authors： Kang TH,Hong BN,Park C,Kim SY,Park R

    更新日期：2010-01-29 00:00:00

  • P53-induced microRNA-107 inhibits proliferation of glioma cells and down-regulates the expression of CDK6 and Notch-2.

    abstract：:MicroRNAs (miRNAs) are small noncoding RNAs that function as tumor suppressors or oncogenes. MicroRNA-107 (miR-107), a transcriptional target of p53, is deregulated in many cancer cell lines. Here, we showed that miR-107 is down-regulated in glioma tissues and cell lines, in particular, p53-mutated U251 and A172. Tran...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2012.11.047

    authors： Chen L,Zhang R,Li P,Liu Y,Qin K,Fa ZQ,Liu YJ,Ke YQ,Jiang XD

    更新日期：2013-02-08 00:00:00

  • Anxiety-like behaviors in mice lacking GIT2.

    abstract：:G protein-coupled receptor kinase-interactor 2 (GIT2) is a signaling scaffold protein that also functions as GTPase-activating protein (GAPs) for ADP-ribosylation factor (Arf) small GTP-binding proteins. GIT2 has been implicated in the regulation of G protein-coupled receptor trafficking and cell adhesion and migratio...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2008.12.034

    authors： Schmalzigaug R,Rodriguiz RM,Phillips LE,Davidson CE,Wetsel WC,Premont RT

    更新日期：2009-02-20 00:00:00

  • Distribution and ultrastructure of ventral root afferents to lamina I of the cat sacral spinal cord.

    abstract：:Following ventral root injury-filling with horseradish peroxidase at sacral spinal levels S1, S2, and S3, small fascicles of axons can be observed to enter the ventral portion of lamina I and arborize primarily in the dorsolateral region just medial to the tract of Lissauer (TL). Some axons enter the TL and turn in a ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(87)90182-0

    authors： Beattie MS,Bresnahan JC,Mawe GM,Finn S

    更新日期：1987-04-23 00:00:00

  • Spinal opioid receptors and inhibition of urinary bladder motility in vivo.

    abstract：:The effects of intrathecal injections of morphine and other opioid receptor selective drugs were tested on urinary bladder contractions in the anesthetized rat. Morphine produced dose-related inhibition of bladder motility which was abolished by naloxone. This action was also observed with mu- and delta-opioid recepto...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(84)90390-2

    authors： Dray A,Metsch R

    更新日期：1984-06-01 00:00:00

  • Striatal neuropeptide Y neurones are under the influence of the nigrostriatal dopaminergic pathway: immunohistochemical evidence.

    abstract：:Selective unilateral 6-hydroxydopamine lesion of the nigrostriatal dopaminergic neurones in rats resulted, 12 to 90 days later, in a marked increase in the number of neuropeptide Y (NPY)-immunoreactive perikarya in the ipsilateral deafferented striatum compared to the contralateral intact side in the same animal and t...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(86)90174-6

    authors： Kerkerian L,Bosler O,Pelletier G,Nieoullon A

    更新日期：1986-05-06 00:00:00