Abstract:
:Selective unilateral 6-hydroxydopamine lesion of the nigrostriatal dopaminergic neurones in rats resulted, 12 to 90 days later, in a marked increase in the number of neuropeptide Y (NPY)-immunoreactive perikarya in the ipsilateral deafferented striatum compared to the contralateral intact side in the same animal and to both sides in control animals. The staining intensity of most positive cells also appeared to be enhanced in the deafferented striatum. These effects which can be interpreted as resulting from an increase in the intraneuronal levels of NPY may be accounted for by an increased production or a decreased metabolization of the peptide in the striatum deafferented from its dopaminergic input. The results therefore provide morphological evidence that the NPY-containing neuronal system of the striatum may undergo tonic influence from nigrostriatal dopaminergic afferents.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Kerkerian L,Bosler O,Pelletier G,Nieoullon Adoi
10.1016/0304-3940(86)90174-6subject
Has Abstractpub_date
1986-05-06 00:00:00pages
106-12issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(86)90174-6journal_volume
66pub_type
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