Abstract:
:Recent evidence suggests a predominant role for potassium (K) efflux in apoptotic cell death yet there exists controversy as to the exact nature of this involvement of K. In the present study we tested the anti-apoptotic efficacy of K channel blockers, tetraethylammonium Cl (TEA), and high extracellular K, the sodium (Na) channel blocker, tetrodotoxin (TTX) and the Cl channel blocker, 4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid, (SITS) against staurosporine-induced apoptosis in primary rat cortical cultures. Surprisingly, we failed to observe anti-apoptotic effects with TEA, high K or TTX. We did, however, observe significant dose-dependent inhibition of apoptosis with SITS. In conclusion we demonstrate no role for K or Na in neuronal apoptosis, but rather an important role for a SITS-sensitive mechanism such as Cl.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Small DL,Tauskela J,Xia Zdoi
10.1016/s0304-3940(02)01107-2keywords:
subject
Has Abstractpub_date
2002-12-13 00:00:00pages
95-8issue
2eissn
0304-3940issn
1872-7972pii
S0304394002011072journal_volume
334pub_type
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