Differential expression of sialoglycoproteins in the rat hippocampus and its changes during aging.

Abstract:

:The distribution pattern of sialylated glycoproteins in the hippocampal formation of 9-week-old and 29-month-old rats was examined using Maackia amurensis lectin, specific for Sia alpha2-3Gal, and Sambucus sieboldiana agglutinin specific for Sia alpha2-6Gal(GalNAc), and a monoclonal antibody for a linear homopolymer of alpha2-8-linked sialic acid. Each lectin and antibody showed different and characteristic staining patterns. On comparison of younger and older animals, different staining patterns were revealed. These results indicate that sialoglycoproteins with different sialyl linkages were expressed in distinct regions of the rat brain and their expression patterns changed with aging.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Sato Y,Endo T

doi

10.1016/s0304-3940(99)00032-4

keywords:

subject

Has Abstract

pub_date

1999-02-26 00:00:00

pages

49-52

issue

1

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(99)00032-4

journal_volume

262

pub_type

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