Branching enhancement by basic fibroblast growth factor in cut neurite of hippocampal neurons.

Abstract:

:Basic fibroblast growth factor (bFGF) has strong neurotrophic effects both in vivo and in vitro on various brain neurons. bFGF enhanced the branching of laser beam-damaged axons of primary cultured hippocampal neurons with a suppression of the neurite's re-elongation. Conditioned medium prepared from astrocytes, on the contrary, prolonged the length of the cut neurite, but lacked a branching enhancement effect. Other neurotrophic factors, such as nerve growth factor and epidermal growth factor, did not affect the neurite branching or re-elongation. These results suggest that bFGF prevents neuronal death through promoting the branching of the cut neurite.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Miyagawa T,Saito H,Nishiyama N

doi

10.1016/0304-3940(93)90069-w

subject

Has Abstract

pub_date

1993-04-16 00:00:00

pages

29-31

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(93)90069-W

journal_volume

153

pub_type

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