Abstract:
:The pathological basis for essential tremor (ET) is unknown. We used proton magnetic resonance spectroscopic imaging (1H MRSI) in 16 ET patients and 11 controls to measure levels of intracellular metabolites, including N-acetyl-L-aspartate (NAA) and total choline, relative to total creatine (tCR), in several brain regions (cerebellum, thalamus, basal ganglia). Multislice 1H MRSI data were acquired on a 1.5 T GE Signa Scanner by prescribing four 15-mm axial-oblique slices. The mean (standard deviation) cerebellar cortical NAA/tCR was reduced in cases compared to controls (1.53 [0.36] versus 1.91 [0.49], P = 0.03). There was an inverse association between cerebellar cortical NAA/tCR and dominant arm tremor severity (r = -0.59, P = 0.02). The reduction in cerebellar cortical NAA/tCR indicates that there is neuronal damage or loss in ET, suggesting that ET may be a neurodegenerative disease.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Louis ED,Shungu DC,Chan S,Mao X,Jurewicz EC,Watner Ddoi
10.1016/s0304-3940(02)00966-7keywords:
subject
Has Abstractpub_date
2002-11-15 00:00:00pages
17-20issue
1eissn
0304-3940issn
1872-7972pii
S0304394002009667journal_volume
333pub_type
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