Expression of the junD proto-oncogene in the rat spinal cord and skin following noxious cutaneous ultraviolet irradiation.

Abstract:

:Noxious peripheral stimulation induces the expression of various proto-oncogenes in rat spinal neurons. However, proto-oncogene expression seems to differ depending on the mode of the stimulus. Here, we report that noxious cutaneous ultraviolet (UV) irradiation results in a nearly 8-fold increase in junD mRNA levels in the rat lumbar spinal cord. RNA slot-blotting and hybridization techniques revealed a transcriptional activation of the junD proto-oncogene after 6 h, but not 1 h following UV exposure. These results suggest that low-frequency ongoing afferent impulse discharge is reflected by an accumulation in junD transcripts.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Gillardon F,Wiesner RJ,Zimmermann M

doi

10.1016/0304-3940(92)90654-p

keywords:

subject

Has Abstract

pub_date

1992-02-17 00:00:00

pages

87-90

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(92)90654-P

journal_volume

136

pub_type

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