Abstract:
:Facilitation of synaptic connections between sensory neurons and motor neurons mediating the tail-withdrawal reflex in Aplysia is produced by sensitizing stimuli. These effects can be mimicked by perfusing the pleural and pedal ganglia of a semi-intact preparation with serotonin (5-HT). In addition to the synaptic facilitation, 5-HT produces a depolarization associated with an increase in input resistance in the sensory neurons. The 5-HT-induced changes appear to be mediated by an elevation in cAMP levels. To examine further the role of cAMP in mediating the 5-HT response we utilized the potent cyclase activator forskolin. Forskolin mimics the 5-HT response and blocks the response to subsequent 5-HT applications indicating that both 5-HT and forskolin act through a common saturable mechanism. Voltage clamp and ion substitution experiments indicate that the 5-HT response is due, at least in part, to a decrease in a resting K+ conductance.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Walsh JP,Byrne JHdoi
10.1016/0304-3940(84)90342-2subject
Has Abstractpub_date
1984-11-23 00:00:00pages
7-11issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(84)90342-2journal_volume
52pub_type
杂志文章abstract::Ultrasound can be heard by bone conduction in man. However, there has been no consensus about the perception mechanism of bone-conducted ultrasound (BCU). In the current study, to clarify the central auditory system of BCU, the effects of stimulus duration for 30 kHz BCU on N1m were compared with those for air-conduct...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(02)00409-3
更新日期:2002-07-19 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(00)01529-9
更新日期:2000-11-03 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:
更新日期:1996-10-18 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(97)00181-x
更新日期:1997-03-28 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(92)90755-v
更新日期:1992-09-14 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(91)90389-b
更新日期:1991-09-16 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2016.05.058
更新日期:2016-08-03 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(03)00119-8
更新日期:2003-05-01 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)90196-1
更新日期:1994-11-21 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)90764-1
更新日期:1994-09-12 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2012.11.047
更新日期:2013-02-08 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.08.081
更新日期:2008-11-07 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2016.03.003
更新日期:2016-04-08 00:00:00
abstract::A replication-defective recombinant adenoviral vector containing E. coli lacZ gene was injected into the gastrocnemius muscles of transgenic mice carrying mutant Cu/Zn superoxide dismutase (SOD1) gene and non-transgenic wild-type mice at 40 weeks of age. After 60 and 90 h of the injection, lacZ staining was observed a...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(01)02036-5
更新日期:2001-08-10 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2014.04.028
更新日期:2014-06-13 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(81)90236-6
更新日期:1981-07-02 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(84)90290-8
更新日期:1984-07-13 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(86)90512-4
更新日期:1986-08-04 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(96)12588-x
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2003.09.025
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(01)02056-0
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2013.04.008
更新日期:2013-06-17 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(97)00680-0
更新日期:1997-10-03 00:00:00
abstract::Responses of single neurones to vibrissal stimulation and to the iontophoretically applied putative neurotransmitters, L-glutamate and L-aspartate, were recorded in the trigeminal nucleus caudalis of the rat. Vibrissal responses were unaffected by the specific N-methyl-D-aspartate receptor antagonist, D-alpha-aminoadi...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(81)90085-9
更新日期:1981-03-10 00:00:00
abstract::Interleukin-1 beta (IL-1 beta), interleukin-2 (IL-2), and interleukin-6 (IL-6) were measured in the cerebrospinal fluid (CSF) and plasma of 12 control subjects, 11 sporadic Alzheimer's disease (AD) and 22 de novo Parkinson's disease (PD) patients using high sensitivity enzyme-linked immunosorbent assays (ELISA). IL-1 ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(95)12192-7
更新日期:1995-12-29 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章,评审
doi:10.1016/j.neulet.2017.09.003
更新日期:2019-03-16 00:00:00
abstract::Release of endogenous polyamines may contribute to neuronal loss in ischemia and related conditions. Primary cortical neurons were exposed to spermine and spermidine and subsequently assayed for [3H]ouabain binding to quantify neuronal loss. Neuronal survival was significantly decreased in the presence of spermine at ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(93)90152-b
更新日期:1993-10-14 00:00:00
abstract::The effects of noradrenaline (NA) on synaptic responses in layer II of the entorhinal cortex (EC) were studied in normal and spontaneously epileptic mutant mice tottering using intracellular recording in a slice preparation. Neither the membrane properties of neurones nor the responses to NA differed between normal an...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)90955-5
更新日期:1994-09-26 00:00:00
abstract::RMI 12330A dose-dependently inhibits cAMP accumulation induced by PGE2 in guinea-pig superior cervical ganglion (SCG). Norepinephrine (NE) is unable to modify cAMP concentration in the same preparation. On the other hand, both PGE2 and NE block the firing discharge of guinea-pig SCG neurons elicited by electrical stim...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(82)90274-9
更新日期:1982-10-08 00:00:00
abstract::Abnormal neural activity generated at a site of nerve injury is thought to contribute to the development of dysaesthesia. Vanilloid receptor 1 (TRPV1), a transducer of noxious stimuli, may be involved in the initiation of this abnormal activity and could provide a useful therapeutic target. We investigated the effect ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.06.088
更新日期:2008-09-26 00:00:00