Supraspinal influences on the facilitation of rat nociceptive reflexes induced by carrageenan monoarthritis.

Abstract:

:During hyperalgesia there is an enhancement of wind-up and the appearance of a novel wind-up of the A-fibre-mediated responses. We have examined if these phenomena are influenced by supraspinal mechanisms by analysing single motor unit activity in control and arthritic rats, either intact or acutely spinalised. Enhancement of the C-fibre wind-up and the novel A-fibre wind-up were only observed in the intact arthritic animals. We conclude that C-fibre wind-up is a spinal phenomenon, whereas the enhancement of the C-fibre wind-up and the novel A-fibre wind-up during arthritis depend also on supraspinal influences.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Herrero JF,Cervero F

doi

10.1016/0304-3940(96)12588-x

subject

Has Abstract

pub_date

1996-05-03 00:00:00

pages

21-4

issue

1

eissn

0304-3940

issn

1872-7972

pii

030439409612588X

journal_volume

209

pub_type

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