Abstract:
:Granule neurons from the rat dentate gyrus were acutely isolated and whole-cell currents recorded. Maximal enhancement of 7 microM gamma-aminobutyric acid (GABA; EC30) evoked currents was obtained with 100 microM pentobarbital where the peak-current was 2.1+/-0.2 of control. One hundred microM pentobarbital alone evoked no current response whereas 1 mM pentobarbital elicited a current response that was 0.4+/-0.2 of the 100 microM GABA-activated peak current. In 100 microM pentobarbital, the GABA EC50 value shifted from 14 to 3 microM but the peak-saturating-current value was not altered. An off-current was recorded on removal of 100 microM and higher pentobarbital concentrations. Ten mM pentobarbital abolished the peak-current response to 7 and 100 microM GABA. The results show that in the granule neurons the drug potency differs for the different effects of pentobarbital at GABAA receptors with the modulatory and inhibitory effects requiring lower concentrations than the direct activation of the receptors.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Lim MS,Lindquist CE,Birnir Bdoi
10.1016/j.neulet.2003.09.025keywords:
subject
Has Abstractpub_date
2003-12-19 00:00:00pages
139-42issue
2eissn
0304-3940issn
1872-7972pii
S0304394003011200journal_volume
353pub_type
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