Abstract：
:Galectin-3 is a β-galactosidase-binding lectin which is important in cell proliferation and apoptotic regulation. Encephalomyocarditis virus (EMCV), which includes the Enterovirus genus, can cause not only acute myocarditis but also neuronal degeneration of central nervous system in various animals including mice. The pathophysiological role of galectin-3 in central nervous system following acute viral infection is not fully understood. The goal of this study is to determine the localization and time-course of galectin-3 expression after acute viral inoculation with EMCV. Galectin-3 is up-regulated in degenerated lesions of brain area including cerebellum, hippocampus, thalamus and cerebral hemisphere, 96 h after EMCV inoculation. At the same time, Iba-1 positive microglia was morphologically activated within and around the focus of infection. Interestingly, in cerebellum, the microlesions containing a few galectin-3 cells were detected in the immediate-early phase of infection, as early as 48 h after EMCV inoculation. Thus, our results indicate that galectin-3 expression may be a key mediator between viral infection and neuronal degeneration in central nervous system including cerebellum. Furthermore, detection of galectin-3 might be an early diagnostic method for neuronal degeneration after virus infection.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Kobayashi K,Niwa M,Hoshi M,Saito K,Hisamatsu K,Hatano Y,Tomita H,Miyazaki T,Hara Adoi
10.1016/j.neulet.2015.02.061subject
Has Abstractpub_date
2015-04-10 00:00:00pages
107-12eissn
0304-3940issn
1872-7972pii
S0304-3940(15)00176-7journal_volume
592pub_type
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