Reduced long-term potentiation in the dentate gyrus of transgenic mice with cerebral overexpression of interleukin-6.

Abstract:

:The cytokine interleukin-6 (IL-6) may be a contributing mediator of CNS injury in several neurological disorders. To investigate the role of IL-6 in memory-related disorders, we examined transgenic mice (GFAP-IL6) with cerebral overexpression of IL-6 using paired-pulse facilitation, paired-pulse inhibition, and long-term potentiation (LTP) in an in vitro preparation. We found that paired-pulse potentiation and inhibition in the dentate gyrus of hippocampal slices prepared from the GFAP-IL6 mice did not differ significantly from age-matched control animals, suggesting that the increase in paired-pulse inhibition seen previously in in vivo studies of this model was due to alterations of afferents from other brain regions. However, LTP in the dentate was significantly reduced in slices from GFAP-IL6 transgenic mice when compared with littermate wild-type controls, providing support for a role of IL-6 in the pathogenesis of neurodegenerative associated memory-related disorders.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Bellinger FP,Madamba SG,Campbell IL,Siggins GR

doi

10.1016/0304-3940(95)11976-4

subject

Has Abstract

pub_date

1995-09-29 00:00:00

pages

95-8

issue

2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(95)11976-4

journal_volume

198

pub_type

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