Reduced long-term potentiation in the dentate gyrus of transgenic mice with cerebral overexpression of interleukin-6.

abstract：:The suprachiasmatic nucleus (SCN) has been known as an oscillator of circadian rhythm and recently some reports suggested that excitatory amino acids were functioning in this nucleus. The purpose of this study is to measure the physiological amino acid content of this nucleus, to estimate the circadian variation in am...

journal_title：Neuroscience letters

authors： Takeuchi Y,Takahashi K

更新日期：1994-09-12 00:00:00

abstract：:Rim is a multi-domain, active zone protein that regulates exocytosis and is implicated in vesicle priming and presynaptic plasticity. We recently demonstrated that synaptic defects associated with loss of Caenorhabditis elegans Rim (termed UNC-10) are accompanied by a reduction in docked vesicles adjacent to the presy...

journal_title：Neuroscience letters

authors： Gracheva EO,Hadwiger G,Nonet ML,Richmond JE

更新日期：2008-10-24 00:00:00

abstract：:Partial depolarization of primary cerebellar neuronal cultures with K+ evoked the release of aspartate, glutamate, adenosine, serine, taurine, gamma-aminobutyric acid (GABA), alanine and proline. The dihydropyridine calcium channel agonist, BAY K 8644, significantly augmented the K+-induced release of adenosine, aspar...

journal_title：Neuroscience letters

authors： Philibert RA,Dutton GR

更新日期：1989-07-17 00:00:00

abstract：:Using immunohistochemistry, Fas and caspase 8 positive sites were localized in the brains of Alzheimer patients and those with multiple infarcts as well as age-matched normal. The frontal, occipital and hippocampal regions were dissected out from these patients and normal individuals shortly after death. Positive Fas ...

journal_title：Neuroscience letters

authors： Yew DT,Ping Li W,Liu WK

更新日期：2004-08-26 00:00:00

abstract：:The present study investigated in vivo the kinetic of the changes in rat striatal extracellular concentrations of dopamine (DA), and its monoamine oxidase (MAO)-derived metabolite 3,4-dihydroxyphenylacetic acid (DOPAC), following administration either of nitric oxide (NO) synthase (NOS) inhibitors 7-nitroindazole (7-N...

journal_title：Neuroscience letters

authors： Desvignes C,Bert L,Vinet L,Denoroy L,Renaud B,Lambás-Señas L

更新日期：1999-04-02 00:00:00

abstract：:The sexual axis of rats can be rendered photoresponsive by testosterone implants. We have studied in these conditions whether rat pars tuberalis (PT) melatonin receptor density would be decreased after exposure to short photoperiod (SP) like as observed in long day seasonal breeders. The answer is no, but we observed ...

journal_title：Neuroscience letters

authors： Recio J,Pévet P,Míguez JM,Masson-Pévet M

更新日期：1996-08-16 00:00:00

abstract：:Regeneration of reduced nicotinamide adenine dinucleotide phosphate (NADPH) is essential for the activity of glutathione redox cycling during cellular peroxide detoxification. In order to test for a function of astroglial glycogen to serve as endogenous precursor for glucose-6-phosphate, the substrate for the regenera...

journal_title：Neuroscience letters

authors： Rahman B,Kussmaul L,Hamprecht B,Dringen R

更新日期：2000-09-01 00:00:00

abstract：:Rabbit retinal Müller cells were isolated by means of papaine and mechanical dissociation. These cells were shown to have a well preserved morphology and to preserve viability for many hours. Intense wheat germ agglutinin binding occurs on the photoreceptor side of Müller cells, especially in the microvillous region. ...

journal_title：Neuroscience letters

authors： Reichenbach A,Dettmer D,Brückner G,Neumann M,Birkenmeyer G

更新日期：1985-03-22 00:00:00

abstract：:Neovascularization of the dissociated central nervous tissue transplanted into the lateral ventricle of the rat was studied using laminin immunohistochemistry. A very high immunoreactive response to laminin was demonstrated in the presumably newly formed vessels within the transplants and the graft-host borders. The g...

journal_title：Neuroscience letters

authors： Shigematsu K,Kamo H,Akiguchi I,Kameyama M,Kimura H

更新日期：1989-04-24 00:00:00

abstract：:Age-related neurodegenerative diseases are of critical concern to the general population and research/medical community due to their health impact and socioeconomic consequences. A feature of most, if not all, neurodegenerative disorders is the presence of proteinopathies, in which misfolded or conformationally altere...

journal_title：Neuroscience letters

authors： Chung KM,Hernández N,Sproul AA,Yu WH

更新日期：2019-04-01 00:00:00

abstract：:Urotensin I-like immunoreactivity (UILI), in different localization from that of corticotropin releasing factor-like immunoreactivity (CRFLI), in the goldfish retina has been demonstrated by means of radioimmunoassay, high-performance liquid chromatography (HPLC) and immunohistochemistry. Radioimmunoassay showed 350 +...

journal_title：Neuroscience letters

authors： Sakanaka M,McMaster D,Chohan K,Shibasaki T,Stell WK,Lederis K

更新日期：1987-04-23 00:00:00

abstract：:The subliminal affective priming was studied by recording event-related potential (ERP) to ambiguous neutral faces preceded by 20ms positive or negative prime faces. Behavioral results showed that positive and negative prime faces led to valance-consistent biases in affective judgments of ambiguous neutral faces. ERP ...

journal_title：Neuroscience letters

authors： Lu Y,Zhang WN,Hu W,Luo YJ

更新日期：2011-09-20 00:00:00

abstract：:Evidence indicates that sympathetic nerves and substance P (SP) are involved in some physiological and pathophysiological changes and activities in retina. The aim of this study was to investigate whether SP participates in the stress reaction and possible involvement of adrenergic mechanisms in modulation of the chan...

journal_title：Neuroscience letters

authors： Yang JH,Meng XX,Xie LS,Guo Z

更新日期：2008-10-10 00:00:00

abstract：:We used the mismatch negativity event-related potential to examine how spatial location and feature variation affect the capacity of the auditory system to automatically respond to pairs of rapid (180 ms apart) acoustic changes within a single tone. When a tone first deviated from a standard tone in source location an...

journal_title：Neuroscience letters

authors： Deouell LY,Karns CM,Harrison TB,Knight RT

更新日期：2003-01-02 00:00:00

abstract：:Peripheral motor nerves have revealed variability in excitability by hyperpolarizing current at specific target response levels, likely reflecting differences in the hyperpolarization-activated current (Ih). Whether such variability in Ih exists in sensory axons is yet to be established. We performed nerve excitabilit...

journal_title：Neuroscience letters

authors： Nodera H,Rutkove SB

更新日期：2012-06-19 00:00:00

abstract：:We combined fluorescent tracing with immunohistochemistry to examine nitric oxide synthase (NOS) containing neurons in the rat ventral lateral geniculate nucleus (vLGN). NOS immunopositive neurons in vLGN had a similar appearance to previously described NADPH-d positive neurons. The majority (96%) of the NOS immunopos...

journal_title：Neuroscience letters

authors： Meng XW,Ohara PT,Ralston HJ 3rd

更新日期：1998-11-06 00:00:00

abstract：:Statins were recently shown to possess anti-inflammatory activities, which might be responsible for their favourable effects in cardiovascular or CNS disorders independently from the inhibition of hydroxy-methyl-glutaryl CoA reductase. Here we investigated the effects of the statins lovastatin and mevastatin on prosta...

journal_title：Neuroscience letters

authors： Tringali G,Vairano M,Dello Russo C,Preziosi P,Navarra P

更新日期：2004-01-09 00:00:00

abstract：:We examined whether bisphenol A (BPA) and 4-nonylphenol (NP) influenced staurosporine-induced neuronal cell death in primary cultured rat hippocampal and cortical neurons. In hippocampal neurons, 17beta-estradiol (E2) (1 nM and 10 microM) and BPA (10 microM) significantly inhibited the staurosporine-induced release of...

journal_title：Neuroscience letters

authors： Negishi T,Ishii Y,Kyuwa S,Kuroda Y,Yoshikawa Y

更新日期：2003-12-19 00:00:00

abstract：:The atypical serine/threonine protein kinase, a mammalian target of rapamycin (mTOR), is believed to be essential to the regulation of cell growth and the functions of the central nervous system. By using calcium imaging and patch-clamping techniques to study the role of this signaling pathway in the activity of cultu...

journal_title：Neuroscience letters

authors： Li RX,Yu XZ,Fu M,Zong M,Liu RL,Xie ZP

更新日期：2008-08-15 00:00:00

abstract：:Although the coadministration of lidocaine with propranolol interferes with the metabolic profile (pharmacokinetics), its pharmacodynamics is still unclear. In this report, we investigate whether propranolol can potentiate the effect of lidocaine. Rats received spinal anesthesia with lidocaine co-injected with propran...

journal_title：Neuroscience letters

authors： Chen YW,Chu CC,Chen YC,Hung CH,Li YT,Wang JJ

更新日期：2011-09-26 00:00:00

abstract：:Recently, the potent cholinesterase inhibitor (-)-huperzine A (HupA) was demonstrated to protect neuronal and glial cells against the cytotoxicity of beta-amyloid (Abeta). Since the unnatural (+)-HupA is a much less potent inhibitor, it was of interest to examine the stereoselectivity of cellular protection by the two...

journal_title：Neuroscience letters

authors： Zhang HY,Liang YQ,Tang XC,He XC,Bai DL

更新日期：2002-01-14 00:00:00

abstract：:Diazoxide is a putative mitochondrial, ATP-sensitive potassium channel opener that has been implicated in neuroprotection in cerebral ischemia. Administered as pretreatment, diazoxide can attenuate ischemia-related neuronal injury, but little is known about the potential neuroprotective properties of the drug when it ...

journal_title：Neuroscience letters

authors： Farkas E,Timmer NM,Domoki F,Mihály A,Luiten PG,Bari F

更新日期：2005-10-28 00:00:00

abstract：:Abnormalities of cortical representational maps and their plasticity have been described in dystonia. A common polymorphism for BDNF has been associated with abnormal cortical plasticity, and thus might contribute to pathogenesis of dystonia in some subjects. As a first step towards this suggestion, the current study ...

journal_title：Neuroscience letters

authors： Cramer SC,Sampat A,Haske-Palomino M,Nguyen S,Procaccio V,Hermanowicz N

更新日期：2010-01-01 00:00:00

abstract：:To elucidate the metabolic process generating amyloid-beta protein (A beta) from beta-amyloid precursor protein (APP) in human brain, we partially purified secretory forms and carboxyl-terminal fragments (CTFs) of APP from the white matter of a Down's syndrome brain. We obtained secretory forms of APP which lack the e...

journal_title：Neuroscience letters

authors： Tokuda T,Tanaka K,Kametani F,Ikeda S,Yanagisawa N

更新日期：1995-02-17 00:00:00

abstract：:Integrin-associated protein (IAP) is normally localized to the synapse rich plexiform layers of the mammalian retina. In other neuronal systems, IAP and its ligand, P84, have been implicated in synaptic function. Previously, an abnormal distribution of P84 was noted in the IAP-null retina. To examine the potential rol...

journal_title：Neuroscience letters

authors： Ball SL,Lindberg FP,Lagenaur CF,Peachey NS

更新日期：2001-02-02 00:00:00

abstract：:The subcommissural organ (SCO) is a glandular circumventricular organ secreting glycoproteins into the cerebrospinal fluid. The SCO of 15-week-old spontaneously hypertensive rats (SHR) and of matched normotensive Wistar-Kyoto rats (WKY) was studied immunocytochemically by using an antibody against the glycoproteins se...

journal_title：Neuroscience letters

authors： Castañeyra-Perdomo A,Carmona-Calero E,Meyer G,Pérez-González H,Pérez-Delgado MM,Marrero-Gordillo N,Rodríguez S,Rodríguez EM

更新日期：1998-05-01 00:00:00

abstract：:We investigated the relation between visual feedback and the degree of structure versus randomness in the variability of single-digit, isometric force output. Participants were instructed to maintain a constant level of force during the presence or absence of visual feedback about force output. The structure of force ...

journal_title：Neuroscience letters

authors： Athreya DN,Van Orden G,Riley MA

更新日期：2012-03-28 00:00:00

abstract：:Neocortical neurofibrillary tangles (NFT) revealed by Bodian technique and anti-tau immunolabelling were seen in 5/5 cases of progressive supranuclear palsy (PSP) aged 58-76 years. These lesions differed from Alzheimer's disease or age-related changes: (1) they were most frequent in the precentral gyrus (Brodmann's ar...

journal_title：Neuroscience letters

authors： Hauw JJ,Verny M,Delaère P,Cervera P,He Y,Duyckaerts C

更新日期：1990-11-13 00:00:00

abstract：:The regional distribution of binding sites labeled by [3H]haloperidol, in the presence of excess spiroperidol, was compared to the regional distribution of receptors labeled by [3H]SCH 23390 and [3H]sulpiride, [3H]SCH 23390 and [3H]sulpiride labeled distinct nuclei, such as the olfactory tubercle, caudate, globus pall...

journal_title：Neuroscience letters

authors： Contreras PC,Quirion R,Gehlert DR,Contreras ML,O'Donohue TL

更新日期：1987-03-31 00:00:00

abstract：:Central serotonergic neurotransmission has been implicated in the aetiology of ethanol tolerance and dependence. Cellular expression of the serotonin transporter and serotonin reuptake is modulated via a polymorphic, repetitive element in the 5'-flanking regulatory region of the serotonin transporter gene (5-HTTLPR). ...

journal_title：Neuroscience letters

authors： Türker T,Sodmann R,Goebel U,Jatzke S,Knapp M,Lesch KP,Schuster R,Schütz H,Weiler G,Stöber G

更新日期：1998-06-05 00:00:00