Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase.

abstract：:Neuronal voltage-dependent P/Q Ca2+ channels are genetically abnormal in many cases of familial hemiplegic migraine and possibly associated with the more common forms of migraine with and without aura. Besides the brain, these channels are found in motor nerve endings where they control stimulation-induced acetylcholi...

journal_title：Neuroscience letters

authors： Ambrosini A,de Noordhout AM,Alagona G,Dalpozzo F,Schoenen J

更新日期：1999-12-10 00:00:00

abstract：:Since the mRNA level of Fyn, a neurodevelopmental molecule, expression had been reported to be increased in postmortem schizophrenic prefrontal cortex and showed a strong correlation with age of disease onset, we investigated whether the three polymorphisms of the Fyn gene on genomic DNA (-93A/G, IVS10+37T/C and Ex12+...

journal_title：Neuroscience letters

authors： Ohnuma T,Shibata N,Matsubara Y,Sato S,Yamashina M,Arai H

更新日期：2003-05-29 00:00:00

abstract：:The localisation of transforming growth factor-beta-2 (TGF-beta 2) in skeletal muscles was investigated with immunohistochemistry. In neonates, TGF-beta 2 was distributed throughout the muscle fibres but as the fibres matured TGF-beta 2 became restricted to the circumference of a small subpopulation of nuclei. These n...

journal_title：Neuroscience letters

authors： McLennan IS,Koishi K

更新日期：1994-08-15 00:00:00

abstract：:Nerve guide implants approved for human application in the peripheral nervous system generally fail to bridge lesion gaps longer than 2 cm and cannot match the clinical performance of autologous nerve transplants. Since current synthetic implants are simply hollow tubes, we aim to recreate the native microarchitecture...

journal_title：Neuroscience letters

authors： Nichterwitz S,Hoffmann N,Hajosch R,Oberhoffner S,Schlosshauer B

更新日期：2010-10-29 00:00:00

abstract：:Both chronic pain and depression are debilitating diseases, which often coexist in clinic. However, current analgesics and antidepressants exhibit limited efficacy for this comorbidity. The present study aimed to investigate the effect of ketamine on the comorbidity of inflammatory pain and consequent depression-like ...

journal_title：Neuroscience letters

authors： Zhang GF,Wang J,Han JF,Guo J,Xie ZM,Pan W,Yang JJ,Sun KJ

更新日期：2016-09-19 00:00:00

abstract：:Neuropeptides orexin-A and -B are related to the regulation of sleep/wakefulness and feeding behaviors. Recently, the peptides have also been shown to yield antinociceptive effects in various pain models. However, it is not clear whether orexins are involved in forms of synaptic plasticity, such as long-term potentiat...

journal_title：Neuroscience letters

authors： Park KB,Weon H

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is the debilitating movement disorder, distinguished by dopaminergic and norepinephrinergic neurodegeneration. Apart from candidate gene mutations, several modifier loci have been reported to be associated with the disease manifestation. The Dopamine β-Hydroxylase (DBH) maintains cel...

journal_title：Neuroscience letters

authors： Ghosh A,Sadhukhan T,Giri S,Biswas A,Das SK,Ray K,Ray J

更新日期：2019-07-27 00:00:00

abstract：:We have looked at the effect of synthetic mu-conotoxin GIIIA, a selective blocker of muscle Na channels, on various parameters of synaptic transmission at the frog sartorius nerve-muscle preparation. We found that 5 microM mu-conotoxin consistently blocked muscle action potentials, but had no effect on nerve action po...

journal_title：Neuroscience letters

authors： Sosa MA,Zengel JE

更新日期：1993-07-23 00:00:00

abstract：:The putative anti-addiction alkaloid ibogaine and its principal metabolite 12-hydroxyibogamine appear to act at the (+)-5 methyl-10,11,dihydro-5H- dibenzo[a,d]cycloheten-5-10-imine maleate (MK-801) binding site in the N-methyl-D-aspartate (NMDA)-receptor cation channel. This conclusion is based on findings that both c...

journal_title：Neuroscience letters

authors： Mash DC,Staley JK,Pablo JP,Holohean AM,Hackman JC,Davidoff RA

更新日期：1995-06-02 00:00:00

abstract：:Whole-cell patch clamp recordings were obtained during motor activity from electrically identified motoneurons within the spinal cord of the chick embryo maintained in vitro. Most recordings were performed on E11-E13 motoneurons although it was also possible to record from younger cells (E7-E9). Voltage clamp recordin...

journal_title：Neuroscience letters

authors： Sernagor E,O'Donovan MJ

更新日期：1991-07-22 00:00:00

abstract：:Previous studies have showed that SIN-1, a nitric oxide (NO) donor, injected into the dorsolateral column of the periaqueductal gray (dlPAG) induces flight reactions. This drug, however, can also produce peroxynitrite, which may interfere in this effect. In addition, it is also unknown if this effect is mediated by lo...

journal_title：Neuroscience letters

authors： Braga AA,Aguiar DC,Guimarães FS

更新日期：2009-08-07 00:00:00

abstract：:Centrally formed acetaldehyde has proven to be responsible for several psychopharmacological effects induced by ethanol. In addition, it has been suggested that the cAMP-PKA signaling transduction pathway plays an important role in the modulation of several ethanol-induced behaviors. Therefore, we hypothesized that ac...

journal_title：Neuroscience letters

authors： Tarragon E,Baliño P,Aragon CM

更新日期：2014-09-19 00:00:00

abstract：BACKGROUND:Perinatal hypoxic-ischemic insult is considered a major contributor to child mortality and morbidity and leads to neurological deficits in newborn infants. There has been a lack of promising neurotherapeutic interventions for hypoxic-ischemic brain damage (HIBD) for clinical application in infants. The prese...

journal_title：Neuroscience letters

authors： Zhu H,Qiao L,Sun Y,Yin L,Huang L,Jiang L,Li J

更新日期：2018-04-23 00:00:00

abstract：:This study analyses the finger force sharing using power grip task with adapted experimental conditions. This paradigm limits as much as possible the external constraints when the Index (I), Middle (M), Ring (R) and Little (L) fingers act simultaneously: the thumb did not oppose the other fingers and no secondary mome...

journal_title：Neuroscience letters

authors： Vigouroux L,Rossi J,Foissac M,Grélot L,Berton E

更新日期：2011-10-31 00:00:00

abstract：:The epsilon4 allele of the apolipoprotein E gene (APOE) has repeatedly been associated with increased risk for Alzheimer's disease (AD). Bullido and colleagues recently identified a polymorphism in the promoter region of the APOE gene (-491A/T) and found that -491A homozygosity predicted AD independently of APOE epsil...

journal_title：Neuroscience letters

authors： Town T,Paris D,Fallin D,Duara R,Barker W,Gold M,Crawford F,Mullan M

更新日期：1998-08-14 00:00:00

abstract：:A predominant form of the GABAA/benzodiazepine receptor-Cl- channel complex is believed to consist of three different 48-55 kDa subunits (alpha, beta, gamma) with unknown stoichiometry. Plasmids containing the rat GABAA receptor cDNAs coding for alpha 1, beta 2, and gamma 2 were co-transfected, along with a plasmid en...

journal_title：Neuroscience letters

authors： Hamilton BJ,Lennon DJ,Im HK,Im WB,Seeburg PH,Carter DB

更新日期：1993-04-30 00:00:00

abstract：:Schisandra chinensis is commonly used for food and as a traditional remedy for the treatment of neuronal disorders. However, it is unclear which component of S. chinensis is responsible for its neuropharmacological effects. To answer this question, we isolated α-iso-cubebene, a dibenzocyclooctadiene lignin, from S. ch...

journal_title：Neuroscience letters

authors： Park SY,Park SJ,Park NJ,Joo WH,Lee SJ,Choi YW

更新日期：2013-10-25 00:00:00

abstract：:Large-conductance calcium-activated potassium channels (BK channels) have been suggested to play a substantial role in synaptic transmission in the spinal cord dorsal horn. In the present experiments, we attempted to clarify the physiological significance of BK channels in the modulation of synaptic transmission in th...

journal_title：Neuroscience letters

authors： Furukawa N,Takasusuki T,Fukushima T,Hori Y

更新日期：2008-10-17 00:00:00

abstract：:Physical exercise is beneficial to functional recovery after stroke. But its underling mechanism is still unknown. It is reported that neural stem cells (NSCs) proliferation, migration and differentiation play an important role in recovery following stroke, furthermore, stromal cell derived factor-1α (SDF-1α) and its ...

journal_title：Neuroscience letters

authors： Luo J,Hu X,Zhang L,Li L,Zheng H,Li M,Zhang Q

更新日期：2014-08-22 00:00:00

abstract：:Using a specific radioimmunoassay (RIA), we have quantitated the hypothalamic and extrahypothalamic distribution of vasoactive intestinal polypeptide (VIP) in the rat brain. Highest concentrations of VIP were found in cerebral cortex, suprachiasmatic nucleus, and medial amygdaloid nucleus. Lower concentrations were fo...

journal_title：Neuroscience letters

authors： Samson WK,Said SI,McCann SM

更新日期：1979-05-01 00:00:00

abstract：:Most fibres in adult muscles are derived from secondary myotubes which form around an earlier developing population of primary myotubes. We examined embryonic rat IVth lumbrical muscles at a stage when most secondary myotubes were less than 24 h old, in order to study their acquisition of synaptic terminals. Single ne...

journal_title：Neuroscience letters

authors： Duxson MJ,Ross JJ,Harris AJ

更新日期：1986-11-11 00:00:00

abstract：:The MgATP-dependent priming step of exocytosis has been suggested to be regulated negatively by GTP-binding protein G0 in permeabilized adrenal chromaffin cells. We have reported that synaptosomal-associated protein of 25 kDa (SNAP-25) and vesicle-associated membrane protein 2 (VAMP-2) form a complex in chromaffin cel...

journal_title：Neuroscience letters

authors： Misonou H,Ohara-Imaizumi M,Kumakura K

更新日期：1997-09-05 00:00:00

abstract：:Melatonin protection against H2O2-induced lipid peroxidation in brain homogenates was measured in vitro. The level of malonaldehyde (MDA) plus 4-hydroxyalkenals (4-HDA) was assayed in brain homogenates as an index of induced membrane oxidative damage. Brain homogenates were co-incubated with H2O2 alone or in combinati...

journal_title：Neuroscience letters

authors： Sewerynek E,Poeggeler B,Melchiorri D,Reiter RJ

更新日期：1995-08-11 00:00:00

abstract：:In a random number generation (RNG) task subjects are instructed to generate the numbers 1-10 in a random fashion. RNG performance is assumed to involve executive functions, as it requires controlled response generation and suppression of habitual responses. To investigate cerebral structures involved in RNG associate...

journal_title：Neuroscience letters

authors： Daniels C,Witt K,Wolff S,Jansen O,Deuschl G

更新日期：2003-07-10 00:00:00

abstract：:Neural stem cell (NSC) transplantation has exhibited considerable therapeutic potential in spinal cord injury. However, most experiments in animals have been performed by injecting these cells directly into the injured spinal cord. A cardinal feature of NSCs is their exceptional migratory ability through the nervous s...

journal_title：Neuroscience letters

authors： Takeuchi H,Natsume A,Wakabayashi T,Aoshima C,Shimato S,Ito M,Ishii J,Maeda Y,Hara M,Kim SU,Yoshida J

更新日期：2007-10-16 00:00:00

abstract：:We have recently reported fluctuations in the expression of the period repeat sequence (pp2.5) during light-dark cycles in the suprachiasmatic nucleus (SCN) of rat [Neurosci. Lett., 122 (1991) 113-116]. Presently, we performed in situ hybridization which shows that the fluctuation of pp2.5 expression continues during ...

journal_title：Neuroscience letters

authors： Matsui M,Mitsui Y,Ishida N

更新日期：1993-12-12 00:00:00

abstract：:The effect of a chronic 17 beta-estradiol (10 micrograms, b.i.d.) treatment of 2 weeks to ovariectomized rats was investigated on lateral and medial caudate-putamen dopamine receptors. Dopamine D2 receptors were assayed with [3H]spiperone binding to caudate-putamen homogenates or by autoradiography of forebrain sectio...

journal_title：Neuroscience letters

authors： Falardeau P,Di Paolo T

更新日期：1987-02-10 00:00:00

abstract：:In rats, tight ligation of L5 and L6 spinal nerves produces symptoms of thermal hyperalgesia and mechanical allodynia, mimicking the symptoms which characterise painful peripheral neuropathies in humans. Immunoreactivity for nitric oxide synthase (NOS) was investigated in lumbar (L1, L4, L5 and L6) dorsal root ganglia...

journal_title：Neuroscience letters

authors： Steel JH,Terenghi G,Chung JM,Na HS,Carlton SM,Polak JM

更新日期：1994-03-14 00:00:00

abstract：:The ultrastructure of astrocytic foot processes at the glia limitans in rat optic nerve was studied by freeze-fracture. Two classes of astrocytic end-foot processes were observed. Most astrocytic foot processes in this region show a high density of orthogonal arrays of P-face particles (assemblies) that are randomly o...

journal_title：Neuroscience letters

authors： Black JA,Waxman SG

更新日期：1985-04-19 00:00:00

abstract：:A modified "cross-modal delayed response" paradigm was used to investigate putative processing of face expression in the absence of focused attention to the face. Neutral, happy and sad faces were presented during intervals occurring between a tone and a response imperative signal (a faint click), while subjects were ...

journal_title：Neuroscience letters

authors： Zhao L,Li J

更新日期：2006-12-20 00:00:00