Acute single dose of ketamine relieves mechanical allodynia and consequent depression-like behaviors in a rat model.

abstract：:Interleukin-1 (IL-1) mediates numerous responses on the mouse anterior pituitary cell line AtT-20. We have studied the ligand binding properties of the IL-1 receptors (IL-1R) of the AtT-20 cells and found that they possess 1.5 x 10(3) receptors/cell with a Kd of 0.15 nM for [125I]IL-1 alpha. Using oligonucleotide prim...

journal_title：Neuroscience letters

authors： Bristulf J,Simoncsits A,Bartfai T

更新日期：1991-07-22 00:00:00

abstract：:Cerebellar Purkinje cells differentiate the most elaborate dendritic trees among neurons in the brain and constitute the principal part of cerebellar neuronal circuitry. In the present study, we examined the role of the GluA2 subunit of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate recepto...

journal_title：Neuroscience letters

authors： Tanaka M,Senda T,Hirashima N

更新日期：2017-09-14 00:00:00

abstract：:Serum choline concentrations decrease during and after surgery. We undertook this study to determine whether the decrease of choline is associated with an increase in stress hormones. In 16 patients undergoing abdominal surgery with general anesthesia, circulating choline cortisol, prolactin, adrenocorticotropic hormo...

journal_title：Neuroscience letters

authors： Ozarda Ilçöl Y,Ozyurt G,Kilicturgay S,Uncu G,Ulus IH

更新日期：2002-05-10 00:00:00

abstract：:Astrocyte cell cultures were established from human fetal brains and exposed to human recombinant tumor necrosis factor alpha (TNF alpha) and human recombinant interferon gamma (IFN gamma), and the proliferative response was assessed by bromodeoxyuridine-immunostaining technique. TNF alpha showed an inhibitory activit...

journal_title：Neuroscience letters

authors： Moretto G,Yoo A,Kim SU

更新日期：1993-03-05 00:00:00

abstract：:Differences between neural processing underling day and night vision occur at initial transduction steps. However, comparison of a visual task performance in photopic versus scotopic situations has an intrinsic problem: ambient light levels directly affect the contrast between stimuli and background. By using a simple...

journal_title：Neuroscience letters

authors： Kihara AH,Tsurumaki AM,Ribeiro-do-Valle LE

更新日期：2006-01-23 00:00:00

abstract：:We assessed, by quantitative autoradiography, the density of high-affinity alpha 2-adrenoceptors in hippocampus and frontal cortex sections from 18 patients dying with Alzheimer's disease (AD) in comparison with a control group of 13 matched cases. The full agonist [3H]bromoxidine (UK-14304) was used as a ligand. In A...

journal_title：Neuroscience letters

authors： Pascual J,Grijalba B,García-Sevilla JA,Zarranz JJ,Pazos A

更新日期：1992-08-03 00:00:00

abstract：:Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) has an antalgic effect on acute experimental pain in healthy volunteers. Many published studies have used online stimulation (i.e., tDCS performed during painful stimulation). On the other hand, daily tDCS sessions have been proposed as ...

journal_title：Neuroscience letters

authors： Brasil-Neto JP,Iannone A,Caixeta FV,Cavendish BA,de Mello Cruz AP,Buratto LG

更新日期：2020-09-25 00:00:00

abstract：:Application of a GABAA (gamma-aminobutyric acid-A) receptor antagonist through a microdialysis probe into the forelimb primary motor cortex of ketamine-anesthetized rats induced electromyographic activity in the contralateral forelimb. This activity consisted of spontaneous forelimb movements with a frequency of 0.8 +...

journal_title：Neuroscience letters

authors： Castro-Alamancos MA,Borrell J

更新日期：1993-02-19 00:00:00

abstract：:Astrocytic glial cells from neonatal rat brains were grown in primary culture. Dipeptidyl peptidase II (DPP-II) enzyme activity was measured in cells disrupted by nonionic detergent. The rate of enzyme activity was measured in the presence of various ions, under isosmotic conditions adjusted using mannitol and NaCl. D...

journal_title：Neuroscience letters

authors： Stevens BR,Fernandez A,Sumners C,Hearing L

更新日期：1988-07-08 00:00:00

abstract：:Transcriptomic studies of murine D3 embryonic stem (ES) cells deficient in the purinergic biosynthetic function hypoxanthine guanine phosphoribosyltransferase (HPRT) and undergoing dopaminergic neuronal differentiation has demonstrated a marked shift from neuronal to glial gene expression and aberrant expression of mu...

journal_title：Neuroscience letters

authors： Kang TH,Friedmann T

更新日期：2015-03-17 00:00:00

abstract：:This study investigated the protective effects and mechanisms of crocin, an extract of saffron, on brain damage after traumatic brain injury (TBI) in mice. C57BL/6 mice were subjected to controlled cortical impact (CCI)-induced TBI. Pretreatment with crocin (20mg/kg) had protective effects against TBI, demonstrated by...

journal_title：Neuroscience letters

authors： Wang K,Zhang L,Rao W,Su N,Hui H,Wang L,Peng C,Tu Y,Zhang S,Fei Z

更新日期：2015-03-30 00:00:00

abstract：:Dextromethorphan (DM, 40 or 80 mg/kg, i.p.) and MK-801 (3 or 10 mg/kg, i.p.) were compared in their ability to prevent the depletion of choline acetyltransferase (ChAT) activity in the rat striatum following intrastriatal injection of quinolinic acid. DM did not reduce striatal ChAT depletion following injection of ei...

journal_title：Neuroscience letters

authors： Engber TM,Chase TN

更新日期：1988-12-19 00:00:00

abstract：:Human subjects maintained isometric plantar or dorsal flexions of the ankle in a matching task. H-reflexes of different sizes were superimposed on the steady activity. The peak-to-peak amplitude of the reflexes was measured on the electromyogram (EMG) of the soleus muscle. The size of the corresponding muscle contract...

journal_title：Neuroscience letters

authors： Ruegg DG,Fluri M

更新日期：1989-08-28 00:00:00

abstract：:Direct exposure of rats to tobacco smoke induces antinociception. We presently investigated if this antinociception is mediated via nicotinic and/or mu-opioid receptors. Adult male rats were surgically implanted with Alzet osmotic minipumps that delivered either saline (control), the nicotinic antagonist mecamylamine,...

journal_title：Neuroscience letters

authors： Simons CT,Cuellar JM,Moore JA,Pinkerton KE,Uyeminami D,Carstens MI,Carstens E

更新日期：2005-12-02 00:00:00

abstract：:It is known that 5HTR2A (rs6311) receptors have high concentration in the cortical layer-5 pyramidal neurons and that these receptors play an important role in the modulation of neurocognitive functions. For example, layer-5 pyramidal neurons mediate cellular level integrative interaction of primary sensory afferent s...

journal_title：Neuroscience letters

authors： Maksimov M,Vaht M,Harro J,Bachmann T

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:Mesenchymal stem cells (MSCs) are widely used in regeneration and repair of various tissues and organs, and whether MSC-conditioned medium (MSC-CM) has protective effects in postoperative cognitive dysfunction (POCD) remains largely unknown. We aimed to assess the therapeutic effect and explore the mechanisms...

journal_title：Neuroscience letters

authors： Jiang Y,Gao H,Yuan H,Xu H,Tian M,Du G,Xie W

更新日期：2019-09-14 00:00:00

abstract：:Chronic nicotine administration has been shown previously to produce mechanical hypersensitivity in the rat although the mechanism of this effect is unknown. Rats treated with chronic systemic nicotine 3.6 or 8.6 mg/(kg day) for 14-21 days displayed mechanical hypersensitivity coincident with an increase of prodynorph...

journal_title：Neuroscience letters

authors： Lough C,Young T,Parker R,Wittenauer S,Vincler M

更新日期：2007-07-05 00:00:00

abstract：:[3H]Nitrendipine bound to cerebral cortex membranes is displaced more efficiently by verapamil in old rats (24 months old) compared to young ones (3 months old). In addition, [3H]verapamil binding was studied in detail in 3-, 12- and 24-month-old rats. Aging increases the Bmax of [3H]verapamil, leaving the affinity un...

journal_title：Neuroscience letters

authors： Battaini F,Govoni S,Rius RA,Trabucchi M

更新日期：1985-10-24 00:00:00

abstract：:The cloned vanilloid receptor-1 (VR1) is recognized as a common molecular target for protons, noxious heat, and vanilloids. The presence of VR1 in the dorsal root, trigeminal, and nodose ganglia has been firmly established, but it is unclear in the gut, despite this VR1 may be important for gastric mucosal homeostasis...

journal_title：Neuroscience letters

authors： Nozawa Y,Nishihara K,Yamamoto A,Nakano M,Ajioka H,Matsuura N

更新日期：2001-08-17 00:00:00

abstract：:Pineal serotonin (5-HT), 5-hydroxyindole-acetic acid (5-HIAA), norepinephrine (NE), epinephrine (E) and adrenal corticosterone, NE and E contents were measured spectrofluorometrically 5, 15, 30 and 60 min after insulin treatment to induce hypoglycemic stress. In the pineal gland, hypoglycemic stress caused dramatic de...

journal_title：Neuroscience letters

authors： Mahata SK

更新日期：1991-01-02 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two apparently distinct neurodegenerative diseases, the former characterized by selective loss of motor neurons in the brain and spinal cord and the latter characterized by selective atrophy of frontal and temporal lobes. Over the years, however...

journal_title：Neuroscience letters

authors： Wen X,Westergard T,Pasinelli P,Trotti D

更新日期：2017-01-01 00:00:00

abstract：:Recombinant retroviruses containing the cDNA for human tyrosine hydroxylase-1 and Escherichia coli lacZ gene were used to infect primary foetal ventral mesencephalon and cortical cultures from rat brain. Severe neuronal toxicity resulted 3-4 days after infection, glial cells seemed to be much more resistant. The toxic...

journal_title：Neuroscience letters

authors： Hurley MJ,Bradford HF,O'Hare K,Stern GM,Uchida K

更新日期：1996-12-06 00:00:00

abstract：:The purpose of this study was to determine whether the loss of protein kinase C (PKC) from adrenal chromaffin cells affected the enhancement of high K(+)- and forskolin-stimulated tyrosine hydroxylase (tyrosine 3-monooxygenase, EC 1.14.16.2) activity observed in cells treated with insulin-like growth factor-I (IGF-I)....

journal_title：Neuroscience letters

authors： Dahmer MK

更新日期：1995-12-08 00:00:00

abstract：:To investigate the working mechanism of the conflict processing system, pairs of colored numbers were sequentially presented on a screen to subjects. They were asked to determine if the magnitude or the color of the two numbers was identical. Event-related potentials (ERPs) were recorded at the same time. A negative p...

journal_title：Neuroscience letters

authors： Wang H,Wang Y,Kong J,Cui L,Tian S

更新日期：2001-02-09 00:00:00

abstract：:To explore the possible cellular source and mechanism of apolipoprotein E (apoE) expression in mechanical injured neuronal cultures. Primary cultured mouse cortical neurons were subjected into mechanical injury by needle scratching. The conditioned medium of wild type (WT) primary mouse astrocytes was collected and ad...

journal_title：Neuroscience letters

authors： Yin C,Zhou S,Jiang L,Sun X

更新日期：2012-04-25 00:00:00

abstract：:Previous studies have demonstrated that both visual and proprioceptive feedback influence motor control. The relative contributions of these sensory modalities to the on-line computation of body position--that is, the body schema--remain unclear. We report a study designed to explore the roles of vision and propriocep...

journal_title：Neuroscience letters

authors： Shenton JT,Schwoebel J,Coslett HB

更新日期：2004-11-03 00:00:00

abstract：:The regional cerebral blood flow (rCBF) was measured with positron emission tomography in eight normal volunteers with the purpose of measuring rCBF changes related to the comprehension of an unfamiliar spoken languages. When attempting to comprehend the meaning of words, the left hemisphere showed dominant increases ...

journal_title：Neuroscience letters

authors： Kawashima R,Itoh M,Hatazawa J,Miyazawa H,Yamada K,Matsuzawa T,Fukuda H

更新日期：1993-10-14 00:00:00

abstract：:Statins are lipid-lowering drugs that have been shown to reduce atherosclerotic cardiovascular morbidity and mortality. However, there is growing evidence from epidemiological studies that long-term treatment with statins has unwanted effects on extrahepatic tissue and increases the risk for neuropathy. To investigate...

journal_title：Neuroscience letters

authors： Föcking M,Besselmann M,Trapp T

更新日期：2004-01-23 00:00:00

abstract：:Dopamine receptor D4 (DRD4) is activated by the neurotransmitter dopamine and links to many neurological and psychiatric conditions because of its close relationship with prefrontal cortex and other important brain regions. To explore the possibility that genetic variants of DRD4 gene predispose to children with menta...

journal_title：Neuroscience letters

authors： Zhang K,Zhang M,He H,Zhang J,Chi W,Guo Y,Huang S,Zheng Z,Zhang F,Gao X

更新日期：2012-05-10 00:00:00

abstract：:To identify the roles of gamma-aminobutyric acid (GABA) transporter in epileptogenesis and the recovery mechanisms in spontaneous seizure, a chronological and comparative analysis of GABA transporters (GAT) expression was conducted. GAT-1 immunoreactivity was more strongly detected in the pre-seizure group of seizure ...

journal_title：Neuroscience letters

authors： Kang TC,Kim HS,Seo MO,Park SK,Kwon HY,Kang JH,Won MH

更新日期：2001-09-07 00:00:00