当前位置： SCI文献检索 > NEUROSCIENCE LETTERS期刊下所有文献 > Single 5HTR2A-1438 A/G nucleotide polymorphism affects performance in a metacontrast masking task: implications for vulnerability testing and neuromodulation of pyramidal cells.

Single 5HTR2A-1438 A/G nucleotide polymorphism affects performance in a metacontrast masking task: implications for vulnerability testing and neuromodulation of pyramidal cells.

Abstract：

:It is known that 5HTR2A (rs6311) receptors have high concentration in the cortical layer-5 pyramidal neurons and that these receptors play an important role in the modulation of neurocognitive functions. For example, layer-5 pyramidal neurons mediate cellular level integrative interaction of primary sensory afferent signals and top-down signals exerting contextual modulatory influence. It is also known that genetic variability of 5HTR2A is implicated in individual differences in mental processes. Interestingly, serotonin selectively enhances the asynchronous type of glutamate release when modulating the activity of cortical layer-5 pyramidal neurons, with a post-stimulation delay of this effect at about 50 ms. There are not many behavioral tasks capable of tapping that small temporal intervals in terms of change of the values of independent variables leading to an observable change in the subjects' behavior. However, in the metacontrast masking vision task stimulus onset asynchronies between target and mask critical for the change in the expression of the masking effect correspond to this small temporal value. Thus we hypothesized that genetic variability in 5HTR2A (rs6311) is likely to be associated with different behavioral effects of metacontrast masking and more specifically, that because A allele carriers typically demonstrate greater promoter activity, target-to-mask asynchrony variations should have stronger impact on the masking effect especially with this group of subjects. We obtained support for this hypothesis, but only when target and mask shapes were mutually incongruent.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Maksimov M,Vaht M,Harro J,Bachmann T

doi

10.1016/j.neulet.2014.10.015

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

129-34

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(14)00819-2

journal_volume

584

pub_type

杂志文章

相关文献

NEUROSCIENCE LETTERS文献大全
  • The effect of operant-conditioning balance training on the down-regulation of spinal H-reflexes in a spastic patient.

    abstract：:Spasticity in chronic hemiparetic stroke patients has primarily been treated pharmacologically. However, there is increasing evidence that physical rehabilitation can help manage hyper-excitability of reflexes (hyperreflexia), which is a primary contributor to spasticity. In the present study, one chronic hemiparetic ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2011.09.009

    authors： Hoseini N,Koceja DM,Riley ZA

    更新日期：2011-10-24 00:00:00

  • The effects of aging on cerebellar beta-adrenergic receptor activation and motor learning in female F344 rats.

    abstract：:Female Fischer 344 (F344) rats were tested for age-related differences in both cerebellar beta-adrenergic receptor activation and motor learning. Three and 20 month old rats were tested on a motor learning paradigm that required the rats to adjust their gait to navigate a runway of unevenly spaced pegs. Rates of acqui...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(96)13007-x

    authors： Gould TJ,Bickford PC

    更新日期：1996-09-20 00:00:00

  • Activation of imidazoline I2B receptors is linked with AMP kinase pathway to increase glucose uptake in cultured C2C12 cells.

    abstract：:Guanidine, the active ingredient extracted from Galega officinalis, is introduced as a ligand for imidazoline I2 receptor (I2R) because guanidine decreased plasma glucose via an activation of I2BR to increase glucose uptake into skeletal muscle isolated from Wistar rats. However, the signals for this action of guanidi...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2010.03.024

    authors： Lui TN,Tsao CW,Huang SY,Chang CH,Cheng JT

    更新日期：2010-05-03 00:00:00

  • Neuropeptide Y gene expression in the jerboa arcuate nucleus: modulation by food deprivation and relationship with hibernation.

    abstract：:Using in situ hybridization, the mRNA levels encoding neuropeptide Y (NPY) was investigated in the arcuate nucleus (ARC) of jerboas under three different states of energy balance. (1) normally feeding animals, (2) hibernating animals and finally (3) animals food deprived for 5 days. The hibernating and food deprived j...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(01)01825-0

    authors： El Ouezzani S,Lafon P,Tramu G,Magoul R

    更新日期：2001-06-08 00:00:00

  • Dynamics of directed interactions between brain regions during interburst-burst EEG patterns in quiet sleep of full-term neonates.

    abstract：:The study investigates time-variant directed interactions between brain regions during the interburst-burst EEG pattern (tracé alternant) characteristic of quiet sleep in healthy neonates. The transition from interburst to burst is of particular interest as the generation of the EEG characteristics at burst onset refl...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2010.11.018

    authors： Milde T,Putsche P,Schwab K,Wacker M,Eiselt M,Witte H

    更新日期：2011-01-20 00:00:00

  • Association of interleukin-1 beta polymorphisms with idiopathic Parkinson's disease.

    abstract：:Activated microglia surround degenerating substantia nigra neurons in Parkinson's disease (PD). Such microglia produce high levels of interleukin-1 beta (IL-1 beta) and interleukin-1 alpha (IL-1 alpha). T and C alleles exist for the IL-1 beta-511 regulatory region as well as for the IL-1 alpha-889 regulatory region. T...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(02)00300-2

    authors： McGeer PL,Yasojima K,McGeer EG

    更新日期：2002-06-21 00:00:00

  • Absence/rarity of commonly reported LRRK2 mutations in Indian Parkinson's disease patients.

    abstract：:Recent discovery of pathogenic mutations in the leucine-rich repeat kinase 2 (LRRK2) gene in Parkinson's disease (PD) patients in different ethnic groups have raised a hope of diagnostic screening and genetic counseling. We investigated the six most commonly reported mutations in LRRK2 gene among Indian PD patients, u...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2006.04.052

    authors： Punia S,Behari M,Govindappa ST,Swaminath PV,Jayaram S,Goyal V,Muthane UB,Juyal RC,Thelma BK

    更新日期：2006-12-01 00:00:00

  • Is perception of self-motion speed a necessary condition for intercepting a moving target while walking?

    abstract：:While it has been shown that the Global Optic Flow Rate (GOFR) is used in the control of self-motion speed, this study examined its relevance in the control of interceptive actions while walking. We asked participants to intercept approaching targets by adjusting their walking speed in a virtual environment, and predi...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2014.02.030

    authors： Morice AH,Wallet G,Montagne G

    更新日期：2014-04-30 00:00:00

  • Involvement of peripherally released substance P and calcitonin gene-related peptide in mediating mechanical hyperalgesia in a traumatic neuropathy model of the rat.

    abstract：:We hypothesized that neuropeptides released from the peripheral terminals of primary afferents play an important role in mechanical hyperalgesia after peripheral nerve injury. Nerve injury was performed on rats with lumbar 5 spinal nerve lesion (L5 SNL), which was preceded by L5 dorsal rhizotomy (L5 DR) to avoid the p...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2004.02.043

    authors： Jang JH,Nam TS,Paik KS,Leem JW

    更新日期：2004-04-29 00:00:00

  • Age effect in generating mental images of buildings but not common objects.

    abstract：:Imagining a familiar environment is different from imagining an environmental map and clinical evidence demonstrated the existence of double dissociations in brain-damaged patients due to the contents of mental images. Here, we assessed a large sample of young and old participants by considering their ability to gener...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2015.06.058

    authors： Piccardi L,Nori R,Palermo L,Guariglia C,Giusberti F

    更新日期：2015-08-18 00:00:00

  • Inhibiting dopamine reuptake blocks the induction of long-term potentiation and depression in the lateral entorhinal cortex of awake rats.

    abstract：:Synaptic plasticity in olfactory inputs to the lateral entorhinal cortex may result in lasting changes in the processing of olfactory stimuli. Changes in dopaminergic tone can have strong effects on basal evoked synaptic responses in the superficial layers of the entorhinal cortex, and the current study investigated w...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2007.08.025

    authors： Caruana DA,Reed SJ,Sliz DJ,Chapman CA

    更新日期：2007-10-09 00:00:00

  • The specific NMDA receptor antagonist AP-7 attenuates focal ischemic brain injury.

    abstract：:Pharmacologic blockade of excitatory amino acid receptors, especially the N-methyl-D-aspartate-preferring subclass of glutamate receptors, has been shown to reduce neuronal damage in models of global cerebral ischemia followed by reperfusion. The pharmacologic blockade at the NMDA receptor attenuates infarct size foll...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(89)90322-4

    authors： Roman R,Bartkowski H,Simon R

    更新日期：1989-09-25 00:00:00

  • Morphology of single afferents of the saccular macula in cats.

    abstract：:The morphology of single saccular afferents was studied by the intracellular horseradish peroxidase (HRP) method. Four neurons were sufficiently stained to allow reconstruction of their axonal arborizations. The main axon of these neurons bifurcated into an ascending and a descending branch at the level of the lateral...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(97)00944-0

    authors： Imagawa M,Graf W,Sato H,Suwa H,Isu N,Izumi R,Uchino Y

    更新日期：1998-01-16 00:00:00

  • Microdialysis studies on cortical noradrenaline release: basic characteristics, significance of extracellular calcium and massive post-mortem increase.

    abstract：:Extracellular noradrenaline was measured on-line in the cerebral cortex of the freely moving rat by microdialysis coupled to high performance liquid chromatography and electrochemical detection. High potassium concentrations in the perfusion fluid led to a strong increase, whereas tetrodotoxin led to almost undetectab...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(90)90841-v

    authors： van Veldhuizen MJ,Feenstra MG,Boer GJ,Westerink BH

    更新日期：1990-11-13 00:00:00

  • Glutamate induces a depolarization of adult rat dorsal root ganglion neurons that is mediated predominantly by NMDA receptors.

    abstract：:The effects of glutamate, glutamate receptor agonists and substances that affect glutamate responses were studied, using the whole-cell patch-clamp technique, on neurons isolated from adult rat dorsal root ganglia. In current-clamp, glutamate (100 microM) or the excitatory amino acid receptor agonist N-methyl-D-aspart...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(88)90037-7

    authors： Lovinger DM,Weight FF

    更新日期：1988-12-05 00:00:00

  • Effects of the swimming exercise on the consolidation and persistence of auditory and contextual fear memory.

    abstract：:Exposure to negative environmental events triggers defensive behavior and leads to the formation of aversive associative memory. Cellular and molecular changes in the central nervous system underlie this memory formation, as well as the associated behavioral changes. In general, memory process is established in distin...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2016.06.020

    authors： Faria RS,Gutierres LF,Sobrinho FC,Miranda Ido V,Reis JD,Dias EV,Sartori CR,Moreira DA

    更新日期：2016-08-15 00:00:00

  • Modification of the monoaminergic neurotransmitters in frontal cortex and hippocampus by dietary trans alpha-linolenic acid in piglets.

    abstract：:The effect of partial isomerization of dietary alpha-linolenic acid on the monoaminergic neurotransmitters in piglets was studied. After feeding the animals for 14 days with diets containing or not trans alpha-linolenic acid, neurotransmitters related to the monoaminergic function were quantified in the frontal cortex...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(02)00879-0

    authors： Acar N,Chardigny JM,Berdeaux O,Almanza S,Sébédio JL

    更新日期：2002-10-18 00:00:00

  • The change of circulating insulin like growth factor binding protein 7 levels may correlate with postoperative cognitive dysfunction.

    abstract：:Insulin-like growth factor binding protein (IGFBP) 7 may be a critical regulator of memory consolidation. This study was performed to assess the relationship between circulating IGFBP7 levels and postoperative cognition dysfunction (POCD) in patients scheduled for elective head and neck carcinoma surgery under general...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2014.12.046

    authors： Jiang J,Chen Z,Liang B,Yan J,Zhang Y,Xu H,Huang Y,Jiang H

    更新日期：2015-02-19 00:00:00

  • NEP1-40 alleviates behavioral phenotypes and promote oligodendrocyte progenitor cell differentiation in the hippocampus of cuprizone-induced demyelination mouse model.

    abstract：BACKGROUND:Studies have demonstrated that the failure of oligodendrocyte precursor cells (OPCs) differentiation as a major cause of remyelination failure in demyelinating disease. The reasons for this failure are not completely understood. We hypothesized that the present of myelin debris in CNS play an important role ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2020.134872

    authors： Liu Q,Lv HW,Yang S,He YQ,Ma QR,Liu J

    更新日期：2020-04-23 00:00:00

  • Spatial versus object feature processing in human auditory cortex: a magnetoencephalographic study.

    abstract：:The human visual system is divided into two pathways specialized for the processing of either objects or spatial locations. Neuroanatomical studies in monkeys have suggested that a similar specialization may also divide auditory cortex into two such pathways. We used the identical stimulus material in two experimental...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(02)01063-7

    authors： Herrmann CS,Senkowski D,Maess B,Friederici AD

    更新日期：2002-12-06 00:00:00

  • Serotonin inhibits GABA synaptic transmission in presympathetic paraventricular nucleus neurons.

    abstract：:Activation of serotonin (5-hydroxytryptamine, 5-HT) receptors produces various autonomic and neuroendocrine responses in the hypothalamic paraventricular nucleus (PVN), including increased blood pressure and heart rate. However, the role(s) of 5-HT on the local GABA synaptic circuit have not been well understood in th...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2008.05.012

    authors： Lee KS,Han TH,Jo JY,Kang G,Lee SY,Ryu PD,Im JH,Jeon BH,Park JB

    更新日期：2008-07-11 00:00:00

  • Geomagnetic disturbances are associated with reduced nocturnal excretion of a melatonin metabolite in humans.

    abstract：:The effects of geomagnetic disturbances on urinary excretion of the melatonin metabolite, 6-hydroxymelatonin sulfate (6-OHMS), were studied in conjunction with 60 Hz magnetic field (MF) and ambient light exposure in 132 electric utility workers. Geomagnetic activity was assessed using a local (equivalent amplitude or ...

    journal_title：Neuroscience letters

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0304-3940(99)00308-0

    authors： Burch JB,Reif JS,Yost MG

    更新日期：1999-05-14 00:00:00

  • Co-release of acetylcholine, glutamate and taurine from synaptosomes of Torpedo electric organ.

    abstract：:The amino acid content of Torpedo synaptosomes was investigated. It was found that glutamate and taurine were particularly enriched, their concentration exceeding that of acetylcholine by 50-60%. Other amino acids such as alanine, gamma-aminobutyric acid (GABA), glycine, leucine and phenylalanine were also present, bu...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(87)90171-6

    authors： Vyas S,Bradford HF

    更新日期：1987-11-10 00:00:00

  • Fos in locus coeruleus neurons following audiogenic seizure in the genetically epilepsy-prone rat: comparison to electroshock and pentylenetetrazol seizure models.

    abstract：:Seizures in genetically epilepsy-prone rats (GEPRs) may result from hypoactivity of locus coeruleus (LC) neurons during seizures. This study examined Fos-like-immunoreactivity (FLI) in the LC following audiogenic seizures in two strains of GEPRs (GEPR-9s and -3s), and following pentylenetetrazol (PTZ) or maximal elect...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(97)00611-3

    authors： Eells JB,Clough RW,Browning RA,Jobe PC

    更新日期：1997-09-12 00:00:00

  • Examination of colocalization of calcitonin gene-related peptide- and substance P-like immunoreactivity in the knee joint of the dog.

    abstract：:It is generally assumed that the majority of substance P (SP)-containing afferents are also immunoreactive for calcitonin gene-related peptide (CGRP). In order to determine whether this is also the case in articular afferents where the contents of these peptides are low, we carried out a double labeling study using Fa...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(98)00660-0

    authors： Tamura R,Hanesch U,Schmidt RF,Kumazawa T,Mizumura K

    更新日期：1998-09-18 00:00:00

  • Increased adult neurogenesis in mice with a permanent overexpression of the postsynaptic 5-HT1A receptor.

    abstract：:Depression is among the leading causes of disability and disease burden. Recent studies point to an involvement of altered serotonin1A receptor (5-HT1AR) -mediated adult neurogenesis in depression. However, the exact underlying mechanisms remain unclear, mainly due to the complexity of the serotonergic system with its...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2016.09.051

    authors： Noto B,Klempin F,Alenina N,Bader M,Fink H,Sander SE

    更新日期：2016-10-28 00:00:00

  • A polymorphism in the complement component C1r is not associated with sporadic Alzheimer's disease.

    abstract：:A growing body of evidence suggests that Alzheimer's disease (AD) is associated with local inflammation processes. Complement activation is one of the cardinal pathological features of the inflammation. Intensive AD association studies investigating polymorphisms in inflammatory-related genes have been recently perfor...

    journal_title：Neuroscience letters

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0304-3940(02)01218-1

    authors： Rosenmann H,Meiner Z,Kahana E,Aladjem Z,Friedman G,Ben-Yehuda A,Grenader T,Wertman E,Abramsky O

    更新日期：2003-01-16 00:00:00

  • Stimulus selection via differential response latencies in visual cortical area V4.

    abstract：:Any given region of the cerebral cortex gets multiple inputs, and how these inputs are combined or selected is a key component of cortical function. Experiments in brain slices or other reduced preparations have shown that excitatory inputs to cortex produce a delayed feed-forward inhibition, which suggests that the r...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2008.02.036

    authors： Gawne TJ

    更新日期：2008-04-25 00:00:00

  • Abnormal functional connectivity of motor circuit in the schizophrenic patients with tardive dyskinesia: A resting-state fMRI study.

    abstract：BACKGROUND:Animal and neuroimaging studies suggest that the volume of the motor-circuit region decreases in tardive dyskinesia (TD). This study examined the differences in functional connectivity within the motor circuit of patients with schizophrenia with and without TD to further clarify how the dysfunction is relate...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2020.135548

    authors： Yu T,Li Y,Li N,Huang J,Fan F,Luo X,Tan S,Yang F,Tian B,Tian L,Elliot Hong L,Tan Y

    更新日期：2021-01-18 00:00:00

  • Reduced cortico-motor facilitation in a normal sample with high traits of autism.

    abstract：:Recent research in social neuroscience proposes a link between mirror neuron system (MNS) and social cognition. The MNS has been proposed to be the neural mechanism underlying action recognition and intention understanding and more broadly social cognition. Pre-motor MNS has been suggested to modulate the motor cortex...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2009.10.033

    authors： Puzzo I,Cooper NR,Vetter P,Russo R,Fitzgerald PB

    更新日期：2009-12-25 00:00:00