Abstract:
:Using in situ hybridization, the mRNA levels encoding neuropeptide Y (NPY) was investigated in the arcuate nucleus (ARC) of jerboas under three different states of energy balance. (1) normally feeding animals, (2) hibernating animals and finally (3) animals food deprived for 5 days. The hibernating and food deprived jerboas exhibited a significant increase (130%; P<0.05 and 210%; P<0.01, respectively) of mRNA expression as compared with controls. This elevated NPY mRNA expression supports the hypothesis that NPY may be implicated in abnormal feeding behaviour associated with eating deprivation. The stimulation of NPY gene expression in hibernating jerboas may be related to food deprivation and / or cold exposure since NPY is known to be a hypothermiant factor. It is thus envisaged that NPY within neurons of the ARC plays an integrative role in the control of energy metabolism.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
El Ouezzani S,Lafon P,Tramu G,Magoul Rdoi
10.1016/s0304-3940(01)01825-0keywords:
subject
Has Abstractpub_date
2001-06-08 00:00:00pages
127-30issue
2eissn
0304-3940issn
1872-7972pii
S0304394001018250journal_volume
305pub_type
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