Individual variation in a cholinergic receptor gene modulates attention.

abstract：:The binding site for 1,4-benzodiazepines in the brain is part of the hetero-oligomeric gamma-aminobutyric acid (GABA)A receptor complex which regulates a chloride ion channel. The presence of the gamma 2 subunit in the complex is necessary for the binding of benzodiazepines to their binding site. This study demonstrat...

journal_title：Neuroscience letters

authors： Karle J,Witt MR,Nielsen M

更新日期：1995-12-29 00:00:00

abstract：:N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) has a selective degenerative effect on noradrenergic fibers originating from locus coeruleus (LC) neurons. In the present study, we studied its effect on vigilance states and brain temperature by continuous recordings for periods of 1-5 days and 2-4 weeks following ...

journal_title：Neuroscience letters

authors： González MM,Debilly G,Valatx JL

更新日期：1998-05-29 00:00:00

abstract：:Methamphetamine (METH) is one of the most commonly abused substances in today's society. Many studies have shown that the process of cell death induced by METH involves with the reception of death signals, an increase in pro-apoptotic proteins (Bax) and an activation of cysteine protease death pathway. The objective o...

journal_title：Neuroscience letters

authors： Chetsawang J,Suwanjang W,Pirompul N,Govitrapong P,Chetsawang B

更新日期：2012-01-06 00:00:00

abstract：:To investigate the relationship between apolipoprotein E (APOE) polymorphisms and the severity of traumatic brain injury (TBI) in acute stage in the cohort of mainland Chinese patients. We prospectively identified admissions to the two neurosurgical departments for head injury. A total of 110 subjects with TBI (80 mal...

journal_title：Neuroscience letters

authors： Jiang Y,Sun X,Xia Y,Tang W,Cao Y,Gu Y

更新日期：2006-11-13 00:00:00

abstract：:The administration of DN-1417, a synthetic derivative of TRH with more potent central action, significantly reduced specific [3H]GABA binding in the cerebellum, whereas [3H]GABA binding in the cerebral cortex was not changed. Scatchard analysis showed that the decreased [3H]GABA binding in the cerebellum was due to de...

journal_title：Neuroscience letters

authors： Tatsuoka Y,Kato Y,Imura H

更新日期：1983-12-02 00:00:00

abstract：:This study was aimed to evaluate effects of peptides from Phascolosoma esculenta and its ferrous-chelating peptides on spatial learning and memory in mice by Morris water maze test. 100mg/kg peptide on spatial learning and memory function about quadrant time and passing times through the platform better than 50 and 15...

journal_title：Neuroscience letters

authors： Liu L,Cao J,Chen J,Zhang X,Wu Z,Xiang H

更新日期：2016-09-19 00:00:00

abstract：:To investigate whether the xenon-induced inhibition of the transient receptor potential vanilloid type 1 (TRPV1) ion channel in rat dorsal root ganglion (DRG) neurons reduces nociceptive processing, we examined the effect of xenon in reducing the release of calcitonin gene-related peptide (CGRP) from those neurons. We...

journal_title：Neuroscience letters

authors： Calcott G,White JP,Nagy I

更新日期：2011-07-20 00:00:00

abstract：:We are constantly exposed to symbols such as traffic signs, emoticons in internet communication, or other abstract representations of objects as well as, of course, the written words. However, aside from the word reading, little is known about the way our brain responds when we read non-lexical iconic symbols. By usin...

journal_title：Neuroscience letters

authors： Shin YW,Kwon JS,Kwon KW,Gu BM,Song IC,Na DG,Park S

更新日期：2008-05-16 00:00:00

abstract：:The efficacy of beta 1-adrenoceptor-G protein coupling was studied in postmortem temporal cortex synaptic membranes from a series of control and Alzheimer's disease subjects. For the control cases, the non-hydrolysable GTP analogue 5'-guanylylimidodiphosphate (Gpp[NH]p) gave a significant reduction in the affinity of ...

journal_title：Neuroscience letters

authors： Cowburn RF,Vestling M,Fowler CJ,Ravid R,Winblad B,O'Neill C

更新日期：1993-06-11 00:00:00

abstract：:Ethanol consumption affects levels of endogenous opioids as well as opioid receptors in both animals and humans. We studied the expression of delta (delta) and mu (mu) opioid receptors (ORs) in brain sections of adult male Sprague-Dawley rats after 2 weeks of consuming ethanol in a liquid diet, with comparisons to sec...

journal_title：Neuroscience letters

authors： Saland LC,Hastings CM,Abeyta A,Chavez JB

更新日期：2005-06-10 00:00:00

abstract：:1-methyl-4-phenylpyridinium ion (MPP(+)) has been shown to selectively inhibit mitochondrial function and induce a parkinsonism-like syndrome. MPP(+) stimulates the production of reactive oxygen species (ROS) and induces cell death in vitro. In this study, we investigated the protective effects of okadaic acid on MPP(...

journal_title：Neuroscience letters

authors： Ahn KH,Kim YS,Kim SY,Huh Y,Park C,Jeong JW

更新日期：2009-01-09 00:00:00

abstract：:Excitatory amino acid (EAA) receptor-mediated events have recently been implicated in dopaminergic mechanisms of neurotoxicity. 2,4,5-Trihydroxyphenylalanine (6-hydroxy-DOPA, TOPA), the ortho-hydroxylated derivative of the dopamine precursor 2,4-dihydroxyphenylalanine (L-DOPA), has recently been reported to have neuro...

journal_title：Neuroscience letters

authors： Cha JH,Dure LS IV,Sakurai SY,Penney JB,Young AB

更新日期：1991-10-28 00:00:00

abstract：:Pineal concentrations of 5-methoxytryptamine, 5-methoxytryptophol, 5-methoxyindole acetic acid and melatonin were determined using high performance liquid chromatography following administration of different monoamine oxidase (MAO) inhibitors (clorgyline, pargyline and deprenyl) to golden hamsters. Plasma concentratio...

journal_title：Neuroscience letters

authors： Raynaud F,Pévet P

更新日期：1991-02-25 00:00:00

abstract：:As noted in the aging literature, processing delays often occur in the central nervous system with increasing age, which is often attributable in part to demyelination. In addition, differential slowing between sensory systems has been shown to be most discrepant between visual (up to 20ms) and auditory systems (<5ms)...

journal_title：Neuroscience letters

authors： Stephen JM,Knoefel JE,Adair J,Hart B,Aine CJ

更新日期：2010-10-22 00:00:00

abstract：:To clarify the possible involvement of protein kinase (PK) C activation in the excitation and sensitization of polymodal receptors (PMRs), the effects of phorbol 12,13-dibutyrate (PDBu) on PMRs were studied in canine testis-spermatic nerve preparations in vitro. Application of PDBu (10(-7), 10(-6), AND 10(-5) M) for 5...

journal_title：Neuroscience letters

authors： Leng S,Mizumura K,Koda H,Kumazawa T

更新日期：1996-03-08 00:00:00

abstract：:Reduction of non-protein-bound iron (NPBI) using iron chelators may attenuate hypoxia-ischemia-induced reperfusion injury of the brain. This study investigated whether administration of low-dose deferoxamine and allopurinol, both having NPBI-chelating properties, reduced hypoxia-ischemia-induced NPBI formation in plas...

journal_title：Neuroscience letters

authors： Shadid M,Buonocore G,Groenendaal F,Moison R,Ferrali M,Berger HM,van Bel F

更新日期：1998-05-22 00:00:00

abstract：:Opioids are used in clinical practice to relieve moderate to severe pain. Prolonged use of opioids can lead to a situation of analgesic tolerance and dependence. Several mechanisms are involved in the tolerance to analgesic opioids, including desensitization or internalization of the opioid receptor, elevation of cAMP...

journal_title：Neuroscience letters

authors： Shirooie S,Esmaeili J,Sureda A,Esmaeili N,Mirzaee Saffari P,Yousefi-Manesh H,Dehpour AR

更新日期：2020-01-18 00:00:00

abstract：:The distribution of premotor neurons projecting to motor nuclei of both the VIIth (VII) and XIIth (XII) nerves was examined in the pontomedullary reticular formation (RF) of the rat by using retrograde double labeling. After injection of two different tracers in the VII and the XII, most of the double labeled neurons ...

journal_title：Neuroscience letters

authors： Dauvergne C,Pinganaud G,Buisseret P,Buisseret-Delmas C,Zerari-Mailly F

更新日期：2001-09-28 00:00:00

abstract：:Mutations in APP are associated with familial early-onset Alzheimer disease (FAD). Examination of the genomic sequence in one patient with FAD revealed a change located in the axon 17 of the APP gene at position 275329G>A (GenBank accession number: D87675; GI: 2429080); cDNA sequence 2137G>A (GenBank accession number:...

journal_title：Neuroscience letters

authors： Armstrong J,Boada M,Rey MJ,Vidal N,Ferrer I

更新日期：2004-11-11 00:00:00

abstract：:The neuronal number and nucleolar volume of the magnocellular population of the basal nucleus of Meynert in 6 patients with progressive supranuclear palsy (PSP) - one associated with Alzheimer's disease - were compared with those of 5 controls. In the 5 typical PSP cases, an age-dependent neuronal loss was demonstrate...

journal_title：Neuroscience letters

authors： Tagliavini F,Pilleri G,Bouras C,Constantinidis J

更新日期：1984-01-27 00:00:00

abstract：:The possibility that arterial baroreceptors may be involved in the potentiation of vasopressin or oxytocin secretion observed after noxious stimuli was tested in male rats after sino-aortic denervation (SAD). There was no significant difference in plasma level of vasopressin or oxytocin between the SAD and the corresp...

journal_title：Neuroscience letters

authors： Onaka T,Yagi K

更新日期：1991-11-25 00:00:00

abstract：:Contraction of the isolated tracheal strip to capsaicin was prevented by chronic denervation of the tissue. Tetrodotoxin, hyoscine and hexamethonium caused no inhibition of the response, suggesting that tetrodotoxin-resistant terminal portions of non-cholinergic nerves were activated in this way. There was a strong co...

journal_title：Neuroscience letters

authors： Szolcsányi J

更新日期：1983-11-21 00:00:00

abstract：:We have previously demonstrated that differences in neuropathic pain-like behaviors after sciatic nerve injury genetically maps to the major histocompatibility complex (MHC) in rats carrying RT1(c) or RT1(av1) haplotypes on the Piebald Virol Glaxo (PVG) background. In order to further explore the genetic contribution ...

journal_title：Neuroscience letters

authors： Dominguez CA,Li L,Lidman O,Olsson T,Wiesenfeld-Hallin Z,Piehl F,Xu XJ

更新日期：2008-09-19 00:00:00

abstract：:Nor-binaltorphimine (nor-BNI) is kappa opioid receptor (KOR) antagonist with the extremely long duration in mice analgesic assay, in vivo. For the evaluation of long-lasting effect of nor-BNI, brain content and serum concentration of nor-BNI were quantified in comparison with those of naloxone (a short-acting non-spec...

journal_title：Neuroscience letters

authors： Kishioka S,Kiguchi N,Kobayashi Y,Yamamoto C,Saika F,Wakida N,Ko MC,Woods JH

更新日期：2013-09-27 00:00:00

abstract：:We evaluated long-term dynorphin A-immunoreactivity in the rat area postrema (AP) after the administration of cisplatin. First, rats were given 1, 5 and 10mg/kg body weight cisplatin (i.p.) and their behavior was monitored for 72h. We observed a delayed increase in pica 24-72h after injection, compared to the 24h befo...

journal_title：Neuroscience letters

authors： Tsukamoto G,Ichikawa H,Kobashi M,Yamada Y,Kikuchi T,Mese H,Sasaki A

更新日期：2007-09-07 00:00:00

abstract：:The effect of short-term exercise (15 min step-exercise) on serum brain-derived neurotrophic factor (BDNF) levels was evaluated in healthy human subjects. Results showed a short-term, significant increase in serum BDNF levels after exercise. Intra-individual differences in serum BDNF levels were remarkably small on th...

journal_title：Neuroscience letters

authors： Tang SW,Chu E,Hui T,Helmeste D,Law C

更新日期：2008-01-24 00:00:00

abstract：:To investigate the actions of glucocorticoids (GCs) on astrocyte functions, interactions of dexamethasone and immediate early genes (IEGs) were studied in cell cultures of rat cerebral cortical astrocytes. Vasoactive intestinal peptide (VIP) induces rapid c-fos mRNA expression and morphological changes (stellation) in...

journal_title：Neuroscience letters

authors： Hisanaga K,Sagar SM,Koistinaho J,Hicks KJ,Sharp FR

更新日期：1993-06-25 00:00:00

abstract：:Cisplatin, oxaliplatin, paclitaxel, vincristine and bortezomib are some of the most effective drugs successfully employed (alone or in combinations) as first-line treatment for common cancers. However they often caused severe peripheral neurotoxicity and neuropathic pain. Structural deficits in Dorsal Root Ganglia and...

journal_title：Neuroscience letters

authors： Carozzi VA,Canta A,Chiorazzi A

更新日期：2015-06-02 00:00:00

abstract：:We wanted to verify the magnetic resonance imaging (MRI) abnormalities that occur in the central nervous system (CNS) of cobalamin-deficient (Cbl-D) rats. The rats were made Cbl-D by means of total gastrectomy or feeding a Cbl-D diet. MR images of the cervical tract of the vertebral canal were recorded using a vertica...

journal_title：Neuroscience letters

authors： Veber D,Mutti E,Sironi L,Guerrini U,Gianazza E,Scalabrino G

更新日期：2008-08-08 00:00:00

abstract：:The central projection of vestibular nerve fibers was investigated with anterograde axonal transport of wheatgerm agglutinin-horseradish peroxidase (WGA-HRP) and tritiated leucine following injection in the vestibular ganglion. Labeled fibers and terminal ramifications were observed throughout the vestibular complex, ...

journal_title：Neuroscience letters

authors： Gerrits NM,Epema AH,van Linge A,Dalm E

更新日期：1989-10-23 00:00:00