Disrupted beta 1-adrenoceptor-G protein coupling in the temporal cortex of patients with Alzheimer's disease.

abstract：:The acute thermoregulatory effect of microinjection of capsaicin into the nucleus raphe dorsalis (NRD) has been studied in anesthetised rats. Application of capsaicin (20 micrograms) into the NRD increased the tail skin temperature and decreased the body temperature. In animals that had previously been treated with ca...

journal_title：Neuroscience letters

authors： Hajós M,Hjorth S,Carlsson A

更新日期：1987-03-31 00:00:00

abstract：:Loss of ovarian function, such as occurs with menopause in human beings and ovariectomy in rodents, results in weight gain. Using multiple-time regression analysis, a sensitive technique for quantifying blood-to-brain transport of peptides and polypeptides, we found that mice ovariectomized for at least 5 weeks had ma...

journal_title：Neuroscience letters

authors： Kastin AJ,Akerstrom V,Maness LM

更新日期：2001-09-07 00:00:00

abstract：:In the rat the response of suprachiasmatic nucleus neurons to steady retinal illumination at different adaptation luminances was studied. The results confirm that in this nucleus the discharge rate is more commonly increased than suppressed by light. Interval histograms indicate that a complex process underlies the di...

journal_title：Neuroscience letters

authors： Groos G,Mason R

更新日期：1978-04-01 00:00:00

abstract：:In man, an anesthetic agent that induces surgical anesthesia with minimal influence on descending pyramidal tract activity remains to be found. Anesthesia with ketamine allows recording of stable compound muscle action potentials (CMAPs) to single transcranial magnetic stimulations of the motor cortex (CortStim) in mo...

journal_title：Neuroscience letters

authors： Kothbauer K,Schmid UD,Liechti S,Rösler KM

更新日期：1993-05-14 00:00:00

abstract：:Following the iontophoretic deposition of Phaseolus vulgaris leucoagglutinin (PHA-L) into the rostral ventrolateral medulla (RVL), two-color immunoperoxidase staining was employed to demonstrate contiguity between PHA-L-immunoreactive (PHA-LI) varicose fibers and boutons and brainstem monoaminergic cells. Black-staine...

journal_title：Neuroscience letters

authors： Nicholas AP,Hancock MB

更新日期：1991-01-14 00:00:00

abstract：:Traumatic injury to the central nervous system (CNS) results in the breakdown of the blood-brain barrier and recruitment of hematogenous cells at the site of injury. The role of chemokines in this process has been well recognized and they have been regarded as promising targets for development of anti-inflammatory the...

journal_title：Neuroscience letters

authors： Ghirnikar RS,Lee YL,Li JD,Eng LF

更新日期：1998-05-08 00:00:00

abstract：:By using the monoclonal antibody Alz50, we studied the role of protein kinase C (PKC) in inducing A68 protein expression in a human neuronal cell line. Both phorbol 12-myristate 13-acetate and H7 strongly induced A68 protein, while HA1004 and calphoslin C had no effect. The results suggest that the inhibitor and activ...

journal_title：Neuroscience letters

authors： Zhang L

更新日期：1994-11-07 00:00:00

abstract：:A partially purified toxin obtained from the coral reef crab, Lophozozymus pictor was found to be a potent inhibitor of Na+-dependent [14C]-GABA uptake by rat brain synaptosomes. Inhibition was potentiated in the presence of external K+. The I50 value for the toxin was found to be in the region of 10 microgram/ml at a...

journal_title：Neuroscience letters

authors： Tan CH,Abkowitz SJ

更新日期：1979-10-01 00:00:00

abstract：:There are numerous polymorphisms within the tau gene but these are in complete linkage disequilibrium and exist as two common extended haplotypes H1 and H2. We have investigated the frequency of these haplotypes in 83 cases of sporadic Alzheimer's disease (AD) using the +34 polymorphism in intron 11 of the tau gene as...

journal_title：Neuroscience letters

authors： Green EK,Thaker U,McDonagh AM,Iwatsubo T,Lambert JC,Chartier-Harlin MC,Harris JM,Pickering-Brown SM,Lendon CL,Mann DM

更新日期：2002-05-17 00:00:00

abstract：:The purpose of this study was to determine if the effect of downslope walking (DSW) on spinal excitability depends on walking duration and slope steepness, and if findings from the soleus (Sol) generalize to the tibialis anterior (TA). Sol and TA Hmax and Mmax were measured before and after four DSW doses (time/slope,...

journal_title：Neuroscience letters

authors： Arnold E,Farmer B,Keightley M,Lee D,Rigel T,Hoque M,Sabatier MJ

更新日期：2017-02-03 00:00:00

abstract：:Hypoxic preconditioning (HP) is a novel strategy to make stem cells resistant to the ischemic environment they encounter after transplantation into injured tissue; this strategy improves survival of both the transplanted cells and the host cells at the injury site. Using both in vitro and in vivo injury models, we con...

journal_title：Neuroscience letters

authors： Oh JS,Ha Y,An SS,Khan M,Pennant WA,Kim HJ,Yoon DH,Lee M,Kim KN

更新日期：2010-03-26 00:00:00

abstract：:Delivery of alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionate receptors (AMPARs) to the synapse is a critical factor controlling synaptic strength. It is now established that blockade of synaptic activity increases the surface expression of AMPARs. Factors modulating the delivery, insertion and expression of AMPAR...

journal_title：Neuroscience letters

authors： Wang Y,Barbaro MF,Baraban SC

更新日期：2006-06-19 00:00:00

abstract：:Copper, manganese and zinc were measured by flameless atomic absorption spectrophotometry in the developing brain of normal and quaking mice. The latter is a neurological mutant presenting early arrest of myelination. Copper concentration was increased by 200% between 10 and 20 days after birth and then leveled off in...

journal_title：Neuroscience letters

authors： Cloëz I,Bourre JM

更新日期：1987-12-16 00:00:00

abstract：:Activation of several immediate early genes (IEGs) is crucial for long-term memory formation in vivo. In vitro methods of inducing these genes have not been investigated extensively. Here we present data demonstrating that application of the neurotrophin, nerve growth factor (NGF), to both rat primary neuronal culture...

journal_title：Neuroscience letters

authors： Dickey CA,De Mesquita DD,Morgan D,Pennypacker KR

更新日期：2004-08-05 00:00:00

abstract：:Linkage studies have implicated a broad region on chromosome 10q in Alzheimer's disease (AD). A recent genetic association study has provided evidence that polymorphism in the gene encoding alpha-3 catenin (CTNNA3, referred to previously as VR22 and also known as alpha-T catenin) may underlie linkage signals. Here, to...

journal_title：Neuroscience letters

authors： Blomqvist ME,Andreasen N,Bogdanovic N,Blennow K,Brookes AJ,Prince JA

更新日期：2004-04-01 00:00:00

abstract：:Rehabilitation is a process which favors recovery after brain damage involving motor systems, and neural plasticity is the only real resource the brain has for inducing neurobiological events in order to bring about re-adaptation. Rats were placed on a treadmill and made to walk, in different groups, at different velo...

journal_title：Neuroscience letters

authors： Vázquez-Hernández N,González-Tapia DC,Martínez-Torres NI,González-Tapia D,González-Burgos I

更新日期：2017-09-14 00:00:00

abstract：:We have previously shown that glycine binding sites on presynaptic NMDA receptors (NMDA-Rs) can tonically regulate glutamate release in the rat visual cortex. In the present study, we investigated the subunit composition of these presynaptic NMDA-Rs. We recorded miniature a-amino-3-hydroxy-5-methyl-4-isoxazolepropioni...

journal_title：Neuroscience letters

authors： Li YH,Han TZ,Meng K

更新日期：2008-02-27 00:00:00

abstract：:The actions of agonists and antagonists of excitatory amino acid receptors were studied in the isolated ileal longitudinal muscle-myenteric plexus preparation of the guinea pig incubated 'in vitro', by recording the contraction of the longitudinal muscle. L-Glutamate, L-aspartate, quinolinate and N-methyl-D-aspartate ...

journal_title：Neuroscience letters

authors： Moroni F,Luzzi S,Franchi-Micheli S,Zilletti L

更新日期：1986-07-11 00:00:00

abstract：:Crack is a central nervous system stimulant extracted from the Erythroxylum coca plant. It is considered the most potent and addictive form of cocaine, and its euphoric effects are attained within a few seconds after consumption. Alteration of biological markers of oxidative stress and brain-derived neurotrophic facto...

journal_title：Neuroscience letters

authors： Hirsch GE,Jaskulski M,Hamerski HM,Porto FG,da Silva B,Aita CAM,Kroker K,de Bem Silveira G,Silveira PCL,Santos GT,Klafke JZ,Viecili PRN

更新日期：2018-03-23 00:00:00

abstract：:Molecular forms of butyrylcholinesterase (BuChE) were studied in microvessels isolated from rat brain, using sedimentation analysis in sucrose gradients. Three forms, G1, G2 and G4, were found with sedimentation coefficients close to 3S, 6S and 9S, respectively. The relative proportion of the 3 forms was 19% for the m...

journal_title：Neuroscience letters

authors： Catalán RE,Martínez AM,Aragonés MD,Hernández F

更新日期：1990-11-27 00:00:00

abstract：:The contribution of the circadian pacemaker and the sleep homeostat to sleep tendency and consolidation was quantified by forced desynchrony of the sleep-wake cycle from the circadian pacemaker in eight men who lived in time-isolation for 33-36 days. Analysis of 175 polygraphically recorded sleep episodes revealed tha...

journal_title：Neuroscience letters

authors： Dijk DJ,Czeisler CA

更新日期：1994-01-17 00:00:00

abstract：:Previously we have shown that the 6-sulphatoxymelatonin rhythm of oil rig workers on a 2-week night shift (1800-0600 h) adapts to the shift via a phase delay. We now report the findings of a study on two offshore drill crews working a 1 week day (1200-0000 h), 1 week night (0000-1200 h) swing shift. Urine samples were...

journal_title：Neuroscience letters

authors： Barnes RG,Forbes MJ,Arendt J

更新日期：1998-08-21 00:00:00

abstract：:Regular physical activity benefits brain health and function. Physical activity performed by young adults is declining. However, the influence of diminished physical activity on cognitive performance and motor preparation in young adults remains unclear. This study measured changes in behavior and brain activity durin...

journal_title：Neuroscience letters

authors： Cirillo J,Finch JB,Anson JG

更新日期：2017-01-18 00:00:00

abstract：:Recent studies have shown that the inhibition of histone deacetylases (HDACs) induces the differentiation of diverse cancer and stem cells, which suggests HDAC inhibitors may be good candidates for the induction of stem cell differentiation. In this study, we investigated the effects of a HDAC inhibitor, valproic acid...

journal_title：Neuroscience letters

authors： Jeong SG,Ohn T,Kim SH,Cho GW

更新日期：2013-10-25 00:00:00

abstract：:Several genes expressed in the suprachiasmatic nucleus (SCN) are induced by light and are candidate links in the photic entrainment pathway of the SCN's circadian clock. Since the cAMP response element binding protein (CREB) and CRE-mediated gene transcription in the SCN appears to be crucial for light-induced phase s...

journal_title：Neuroscience letters

authors： Schwartz WJ,Aronin N,Sassone-Corsi P

更新日期：2005-09-02 00:00:00

abstract：:2-Deoxy-d-glucose (2DG) is an analog of glucose that is effectively taken up by cells competing with normal glucose but cannot be further utilized to produce energy. It was previously reported that 2DG can mimic the beneficial effects of dietary restriction in experimental models of neurodegenerative disorders and can...

journal_title：Neuroscience letters

authors： Park M,Song KS,Kim HK,Park YJ,Kim HS,Bae MI,Lee J

更新日期：2009-01-16 00:00:00

abstract：:It has been demonstrated that thyroxine deiodinating activity is present in rat pineal gland, and its activity increases significantly during the night time. We have studied whether mRNA for type II iodothyronine deiodinase is expressed in rat pineal gland and whether the nocturnal rise of pineal T4 deiodinating activ...

journal_title：Neuroscience letters

authors： Murakami M,Hosoi Y,Negishi T,Kamiya Y,Ogiwara T,Mizuma H,Yamada M,Iriuchijima T,Mori M

更新日期：1997-05-09 00:00:00

abstract：:Viral infections of the central nervous system are often associated with seizures, and while patients usually recover from the infection and the seizures cease, there is an increased lifetime incidence of epilepsy. These viral infections can result in mesial temporal sclerosis, and, subsequently, a type of epilepsy th...

journal_title：Neuroscience letters

authors： Smeal RM,Fujinami R,White HS,Wilcox KS

更新日期：2015-11-16 00:00:00

abstract：:Prolactin (PRL) has been shown to be altered by psychotropic drugs, including antidepressant drugs (ADs). Many studies have focused on the response to antidepressant treatment (especially related to the serotonergic system) using the fenfluramine test (PRF), however some data suggest lack of correlation between PRF an...

journal_title：Neuroscience letters

authors： Faron-Górecka A,Kuśmider M,Szafran-Pilch K,Kolasa M,Żurawek D,Gruca P,Papp M,Solich J,Pabian P,Dziedzicka-Wasylewska M

更新日期：2017-04-24 00:00:00

abstract：:The effect of partial isomerization of dietary alpha-linolenic acid on the monoaminergic neurotransmitters in piglets was studied. After feeding the animals for 14 days with diets containing or not trans alpha-linolenic acid, neurotransmitters related to the monoaminergic function were quantified in the frontal cortex...

journal_title：Neuroscience letters

authors： Acar N,Chardigny JM,Berdeaux O,Almanza S,Sébédio JL

更新日期：2002-10-18 00:00:00