The role of protein kinase C in inducing Alzheimer's A68 protein expression in the culture of human neuroblastoma cells.

Abstract:

:By using the monoclonal antibody Alz50, we studied the role of protein kinase C (PKC) in inducing A68 protein expression in a human neuronal cell line. Both phorbol 12-myristate 13-acetate and H7 strongly induced A68 protein, while HA1004 and calphoslin C had no effect. The results suggest that the inhibitor and activator of PKC induce A68 protein expression by different mechanisms.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Zhang L

doi

10.1016/0304-3940(94)90568-1

subject

Has Abstract

pub_date

1994-11-07 00:00:00

pages

95-7

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(94)90568-1

journal_volume

181

pub_type

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