Abstract:
:Brain-derived neurotrophic factor (BDNF) and insulin promote the survival of 6-7 day old post-natal rat cerebellar granule cells. Previous studies using the PI3 kinase inhibitor, wortmannin and the over-expression of protein kinase B (PKB) have indicated that both PI3 kinase and PKB activation are central for insulin-stimulated survival of these neurones. Here we report that BDNF, insulin and epidermal growth factor (EGF) all cause the phosphorylation and stimulation of endogenous PKB activity, though with differing profiles. The addition of BDNF, or insulin resulted in a rapid and sustained phosphorylation and stimulation of PKB activity, whilst EGF stimulation, which does not promote survival, caused a more transient phosphorylation and stimulation of PKB activity. We also investigated the involvement of the PKB substrate, glycogen synthase kinase 3 (GSK 3). All three growth factors caused the inactivation of GSK-3beta, suggesting that the inactivation of GSK-3beta does not correlate with survival.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Foulstone EJ,Tavaré JM,Gunn-Moore FJdoi
10.1016/s0304-3940(99)00166-4keywords:
subject
Has Abstractpub_date
1999-04-02 00:00:00pages
125-8issue
1-3eissn
0304-3940issn
1872-7972pii
S0304-3940(99)00166-4journal_volume
264pub_type
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