Tremorogenesis by physostigmine is unrelated to acetylcholinesterase inhibition: evidence for serotoninergic involvement.

abstract：:A partially purified toxin obtained from the coral reef crab, Lophozozymus pictor was found to be a potent inhibitor of Na+-dependent [14C]-GABA uptake by rat brain synaptosomes. Inhibition was potentiated in the presence of external K+. The I50 value for the toxin was found to be in the region of 10 microgram/ml at a...

journal_title：Neuroscience letters

authors： Tan CH,Abkowitz SJ

更新日期：1979-10-01 00:00:00

abstract：:Heat shock proteins (Hsps) have been regarded as cytoprotectants that protect brain cells from damage encountered following cerebral ischemia or during the progression of neurodegenerative diseases. In this study, we assessed the plasma Hsp70 and Hsp27 levels in not cognitively impaired (NCI) subjects and in patients ...

journal_title：Neuroscience letters

authors： Lee KS,Chung JH,Oh BH,Hong CH

更新日期：2008-05-09 00:00:00

abstract：:Mouse acetylcholine receptors (AChRs) consisting of either the embryonic form (2 alpha, 1 beta, 1 delta and 1 gamma) or the adult form (2 alpha, 1 beta, 1 delta and 1 epsilon) were expressed in Xenopus laevis oocytes. As expected, the single channel conductance was approximately 52 pS and the exponential decay time co...

journal_title：Neuroscience letters

authors： Liu E,Hamill OP,Salpeter MM

更新日期：1994-06-06 00:00:00

abstract：:Synaptic vesicle fusion events are essential for synaptic transmission. Membrane docking and fusion events are highly regulated processes requiring the participation of a large number of soluble N-ethylmaleimide-sensitive factors (SNAREs) and SNARE-interacting proteins. We report the neuronal expression of mammalian h...

journal_title：Neuroscience letters

authors： Kim BY,Ueda M,Nakamura Y,Kohsaka S,Akazawa C

更新日期：2004-01-30 00:00:00

abstract：:Apoptosis is thought to play a role in neuronal pathology in schizophrenia. Recently, the GSN gene was reported to have anti-apoptotic properties. In a genome-wide expression analysis on schizophrenia, GSN was also found to be significantly down-regulated in schizophrenia. All the hints suggest that GSN is a novel can...

journal_title：Neuroscience letters

authors： Xi ZR,Qin W,Yang YF,He G,Gao SH,Ren MS,Peng YW,Zhang Z,He L

更新日期：2004-12-06 00:00:00

abstract：:Presenilin-1 (PSEN1) mutations I143T and G384A give rise to severe early onset Alzheimers's disease in two extensively studied Belgian families, AD/A and AD/B. In this study we investigated the influence of the I143T and G384A mutations on PSEN1 proteolytic processing. Hereto we analyzed PSEN1 processing in lymphoblas...

journal_title：Neuroscience letters

authors： Vanderhoeven I,Cras P,Martin JJ,Van Broeckhoven C,De Jonghe C

更新日期：1999-10-29 00:00:00

abstract：:Previous research has revealed the existence of perceptual mechanisms that compensate for slight temporal asynchronies between auditory and visual signals. We investigated whether temporal recalibration would also occur between auditory and tactile stimuli. Participants were exposed to streams of brief auditory and ta...

journal_title：Neuroscience letters

authors： Navarra J,Soto-Faraco S,Spence C

更新日期：2007-02-08 00:00:00

abstract：:Amplitudes of contingent negative variation (CNV) as a slow cortical potential in migraine patients were recorded before and after migraine attacks. The level of CNV amplitudes, especially of the early component, showed a trend in rise of negativity 1 day before the attack, whereas amplitudes were normal for 2-3 days ...

journal_title：Neuroscience letters

authors： Kropp P,Gerber WD

更新日期：1998-11-27 00:00:00

abstract：:Single-site variants in the calmodulin-binding domain of RC3/neurogranin were heterologously expressed in Xenopus oocytes to examine their effects on serotonin-evoked currents. RC3 variants serine36 -->alanine (Ser36-->Ala), serine36-->glycine (Ser36-->Gly), and phenylalanine37-->tryptophan (Phe37-->Trp), which bind c...

journal_title：Neuroscience letters

authors： Watson JB,Margulies JE,Coulter PM 2nd,Gerendasy DD,Sutcliffe JG,Cohen RW

更新日期：1996-11-29 00:00:00

abstract：:The accumulation of alpha-synuclein, ubiquitin and other proteins in Lewy bodies in degenerating dopaminergic neurones in substantia nigra in idiopathic Parkinson's disease (PD) suggest that inhibition of normal/abnormal protein degradation may contribute to neuronal death. We now show for the first time that the chym...

journal_title：Neuroscience letters

authors： McNaught KS,Jenner P

更新日期：2001-01-19 00:00:00

abstract：:Cholecystokinin (CCK) is suggested to be involved, e.g. in the central nervous modulation of food intake, possibly by acting within specific hypothalamic nuclei. Perinatal overnutrition predisposes to permanent obesity and hyperphagia, while underlying mechanisms are unclear. By reducing the litter size from the 3rd t...

journal_title：Neuroscience letters

authors： Plagemann A,Rake A,Harder T,Melchior K,Rohde W,Dörner G

更新日期：1998-12-11 00:00:00

abstract：:Enteric glial cells are increasingly acknowledged as important partners of enteric neurons in the control of gastrointestinal function. They share morphological features and expression of antigenic markers with astrocytes of the central nervous system. Recently, aldehyde dehydrogenase 1 family member L1 (Aldh1L1) has ...

journal_title：Neuroscience letters

authors： Boesmans W,Rocha NP,Reis HJ,Holt M,Vanden Berghe P

更新日期：2014-04-30 00:00:00

abstract：:We raised polyclonal antibodies against a gene product responsible for late infantile neuronal ceroid lipofuscinosis (CLN2). By Western blotting, all three antisera recognized the CLN2 protein at approximately 49 kDa in human brain homogenates. Immunohistochemistry using the antisera demonstrated the granular labellin...

journal_title：Neuroscience letters

authors： Oka A,Kurachi Y,Mizuguchi M,Hayashi M,Takashima S

更新日期：1998-11-27 00:00:00

abstract：:Substance P (SP) immunocytochemistry and receptor autoradiography were used to define the innervation of the equine synovial membrane of joints equivalent to the wrist and knuckle of man. SP-immunoreactive fibers were mainly concentrated around blood vessels in the subsynovial layer, although not exclusively, while in...

journal_title：Neuroscience letters

authors： Bowker RM,Sonea IM,Vex KB,Caron JP

更新日期：1993-12-24 00:00:00

abstract：:To identify the roles of gamma-aminobutyric acid (GABA) transporter in epileptogenesis and the recovery mechanisms in spontaneous seizure, a chronological and comparative analysis of GABA transporters (GAT) expression was conducted. GAT-1 immunoreactivity was more strongly detected in the pre-seizure group of seizure ...

journal_title：Neuroscience letters

authors： Kang TC,Kim HS,Seo MO,Park SK,Kwon HY,Kang JH,Won MH

更新日期：2001-09-07 00:00:00

abstract：:Taurine increases in brain extracellular space due to glutamate agonists were studied in vivo in the rat hippocampus using a dialysis technique, both in the absence and in the presence of glutamate receptor antagonists. Extracellular taurine levels increased during perfusions of agonists, listed in descending order of...

journal_title：Neuroscience letters

authors： Menéndez N,Herreras O,Solis JM,Herranz AS,Martín del Río R

更新日期：1989-07-17 00:00:00

abstract：:In the last decade, several genes have been linked to Parkinson's disease (PD), including GIGYF2, ATP13A2 and GBA. To explore whether mutations in these genes contribute to development of PD in the Brazilian population, we screened 110 patients with early-onset PD. No clearly pathogenic mutations were identified in AT...

journal_title：Neuroscience letters

authors： Dos Santos AV,Pestana CP,Diniz KR,Campos M,Abdalla-Carvalho CB,de Rosso AL,Pereira JS,Nicaretta DH,de Carvalho WL,Dos Santos JM,Santos-Rebouças CB,Pimentel MM

更新日期：2010-11-19 00:00:00

abstract：:The present study was designed to test the hypothesis that administration of low extracellular levels of magnesium ions ([Mg(2+)](o)) to primary cultured cerebral vascular smooth muscle cells will cause lipid peroxidation, degradation of IkappaB-alpha, and activation of nuclear transcription factor kappa B (NF-kappaB)...

journal_title：Neuroscience letters

authors： Altura BM,Gebrewold A,Zhang A,Altura BT

更新日期：2003-05-08 00:00:00

abstract：:Recently a full genome survey detected an allelic association between Alzheimer's disease (AD) and the D10S1423 marker on chromosome 10p12-14 (40 cM from the telomere). In this study we examined the D10S1423 marker in an ethnically homogeneous German population of 80 AD patients and two groups of controls, 168 healthy...

journal_title：Neuroscience letters

authors： Majores M,Bagli M,Papassotiropoulos A,Schwab SG,Jessen F,Rao ML,Maier W,Heun R

更新日期：2000-08-11 00:00:00

abstract：:Serotonin (5-HT) has been implicated in the regulation of circadian rhythms through its actions on the suprachiasmatic nucleus (SCN). Recent data suggests that, along with excitatory amino acids, serotonin may be important in the neural pathway that mediates the transmission of photic information to the circadian syst...

journal_title：Neuroscience letters

authors： Moyer RW,Kennaway DJ

更新日期：1999-08-27 00:00:00

abstract：INTRODUCTION:Several lines of evidence support an immunologic involvement in obsessive-compulsive disorder (OCD): the increased prevalence of OCD in patients with rheumatic fever (RF), and the aggregation of obsessive-compulsive spectrum disorders among relatives of RF probands. Tumor necrosis factor alpha is a proinfl...

journal_title：Neuroscience letters

authors： Hounie AG,Cappi C,Cordeiro Q,Sampaio AS,Moraes I,Rosário MC,Palácios SA,Goldberg AC,Vallada HP,Machado-Lima A,Nakano E,Kalil J,Pauls D,Pereira CA,Guilherme L,Miguel EC

更新日期：2008-09-12 00:00:00

abstract：:Nitric oxide (NO) is an important messenger in the central nervous system to mediate male copulatory behavior. EGb 761, a standardized extract of Gingko biloba, has been reported to facilitate male copulation in rats. The present study is to determine the effects of neuronal nitric oxide synthase (nNOS) in the medial ...

journal_title：Neuroscience letters

authors： Yeh KY,Wu CH,Tsai YF

更新日期：2011-08-18 00:00:00

abstract：:It is well-known that cocaine dependence is a public health issue, and several studies stress the need to look for new and more effective treatments. Although the mesolimbic dopamine (DA) system, which originates in the ventral tegmental area (VTA) and projects to several forebrain structures, is known to be criticall...

journal_title：Neuroscience letters

authors： Zacarias MS,Ramos AC,Alves DR,Galduróz JC

更新日期：2012-04-04 00:00:00

abstract：:The calcitonin-gene receptor peptide (alphaCGRP) receptor is present in high levels in the caudal striatum of the rat. Previous behavioural experiments have highlighted a possible correlation between alphaCGRP-mediated effects and the dopaminergic system. In this study, we examined the effect of alphaCGRP on K(+)-evok...

journal_title：Neuroscience letters

authors： Maneuf YP,McKnight AT

更新日期：2001-09-14 00:00:00

abstract：:As the pre-dementia phase of Alzheimer disease, mild cognitive impairment (MCI) involves the onset and development of cognitive impairments. Opioid receptors play pivotal roles in the regulation of learning and cognition. Our study focused on the association of OPRK1 and OPRM1 methylation with MCI in Xinjiang Uygur an...

journal_title：Neuroscience letters

authors： Liu G,Ji H,Liu J,Xu C,Chang L,Cui W,Ye C,Hu H,Chen Y,Zhou X,Duan S,Wang Q

更新日期：2017-01-01 00:00:00

abstract：:The acute reactions of vasoactive intestinal polypeptide (VIP)-containing neurons in the myenteric plexus of the rat jejunum in response to circumferential clamping or transection/reanastomosis were evaluated in a detailed time course of up to ten days. Whereas in sham-operated controls VIP immunostaining was confined...

journal_title：Neuroscience letters

authors： Trudrung P,Waldner H,Sklarek J,Nitsch C

更新日期：1990-02-16 00:00:00

abstract：:The present study aimed at investigating how a specific instruction concerning gaze orientation, which involved active head motion, could influence the performance of human subjects in a self-controlled whole-body rotation task in the dark. Subjects were seated on a mobile robotic chair that they controlled using a jo...

journal_title：Neuroscience letters

authors： Siegler I,Israël I

更新日期：2002-11-22 00:00:00

abstract：:Mutations in the glucocerebrosidase (GCase) gene (GBA) and GCase deficiency are major risk factors for Lewy body diseases. Decreased GCase activity enhances alpha-synuclein aggregation and disease development. Lysosomal integral membrane protein type 2, encoded by SCARB2, binds GCase targeting it to lysosomes and tran...

journal_title：Neuroscience letters

authors： Pérez-Roca L,Prada-Dacasa P,Segú-Vergés C,Gámez-Valero A,Serrano-Muñoz MA,Santos C,Beyer K

更新日期：2019-07-27 00:00:00

abstract：:The binding and pharmacological characteristics of [125I]iodomelatonin binding sites in human fetal brain membrane preparations were determined. Membrane preparations of the whole brain revealed a equilibrium binding constant (Kd) of 17.5 pmol/l with a total number of binding sites (Bmax) at 0.8 fmol/mg protein. Among...

journal_title：Neuroscience letters

authors： Yuan H,Lu Y,Pang SF

更新日期：1991-09-16 00:00:00

abstract：:The deposition of amyloid beta protein (Abeta), a proteolytic cleavage product of amyloid precursor protein (APP), is an invariable pathological feature of the Alzheimer's disease brain, while APP gene is widely expressed in all neuronal and non-neuronal tissues with the highest levels of expression in the brain, and ...

journal_title：Neuroscience letters

authors： Tsuzuki K,Fukatsu R,Yamaguchi H,Tateno M,Imai K,Fujii N,Yamauchi T

更新日期：2000-03-10 00:00:00