Substance P innervation of equine synovial membranes: joint differences and neural and nonneural receptor localizations.

Abstract:

:Substance P (SP) immunocytochemistry and receptor autoradiography were used to define the innervation of the equine synovial membrane of joints equivalent to the wrist and knuckle of man. SP-immunoreactive fibers were mainly concentrated around blood vessels in the subsynovial layer, although not exclusively, while in the more distal joint, SP fibers were more frequently seen in the synovial surface layer. Iodinated SP receptor autoradiography studies revealed silver grain concentrations in the advential layer of blood vessels associated with the vasa vasorum, on the vascular endothelium and in the synovial surface. These findings suggest that SP has various sites of action within the synovial membrane, each of which may contribute both a sensory function and a different component of the inflammatory process to the joint.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Bowker RM,Sonea IM,Vex KB,Caron JP

doi

10.1016/0304-3940(93)90861-e

subject

Has Abstract

pub_date

1993-12-24 00:00:00

pages

76-80

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(93)90861-E

journal_volume

164

pub_type

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