Abstract:
:Temperature effects on ocular serotonin N-acetyltransferase (NAT) kinetics characteristics from Rana perezi have been studied with respect to tryptamine and serotonin as substrates. Monoamine oxidase (MAO) activity does not interfere in NAT assay at acceptoramine concentrations used in NAT kinetics characterization from R. perezi retina. NAT shows an inhibition by high substrate (serotonin) concentration, which is temperature-dependent. NAT follows the Michaelis-Menten equation at low temperature, whereas at high temperatures (> 10 degrees C) an inhibition by serotonin is observed. This inhibition of NAT activity by serotonin could act as an amplification mechanism to increase daily melatonin rhythm amplitude in the retina of ectotherms.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Alonso-Gómez AL,Alonso-Bedate M,Delgado MJdoi
10.1016/0304-3940(93)90667-asubject
Has Abstractpub_date
1993-05-28 00:00:00pages
33-6issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(93)90667-Ajournal_volume
155pub_type
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