Serotonergic control of phrenic motoneuronal activity at the level of the spinal cord of the rabbit.

Abstract:

:The role of serotonin (5-hydroxytryptamine, 5-HT)-mediated modulation of phrenic motoneuronal activity was evaluated by microapplication of 5-HT and methysergide into the phrenic nuclei of the rabbit. 5-HT facilitated phrenic nerve activity (PNA) considerably resulting in a long-lasting augmentation of the peak amplitude of integrated PNA. In contrast, the blockade of intrinsically active 5-HT by methysergide decreased PNA and led to a strong reduction of the peak amplitude of integrated PNA. MDL 72222 was ineffective. Blockade of 5-HT receptors by preceding administration of methysergide effectively abolished the effects of microinjected 5-HT. Respiratory timing was unaffected by both the agonist and the antagonist. These results suggest that a considerable portion of the facilitatory influence of caudal raphe nuclei on central respiratory activity takes place at the phrenic nuclei level.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Schmid K,Böhmer G,Merkelbach S

doi

10.1016/0304-3940(90)90411-2

subject

Has Abstract

pub_date

1990-08-14 00:00:00

pages

204-9

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(90)90411-2

journal_volume

116

pub_type

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