Abstract:
:The role of serotonin (5-hydroxytryptamine, 5-HT)-mediated modulation of phrenic motoneuronal activity was evaluated by microapplication of 5-HT and methysergide into the phrenic nuclei of the rabbit. 5-HT facilitated phrenic nerve activity (PNA) considerably resulting in a long-lasting augmentation of the peak amplitude of integrated PNA. In contrast, the blockade of intrinsically active 5-HT by methysergide decreased PNA and led to a strong reduction of the peak amplitude of integrated PNA. MDL 72222 was ineffective. Blockade of 5-HT receptors by preceding administration of methysergide effectively abolished the effects of microinjected 5-HT. Respiratory timing was unaffected by both the agonist and the antagonist. These results suggest that a considerable portion of the facilitatory influence of caudal raphe nuclei on central respiratory activity takes place at the phrenic nuclei level.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Schmid K,Böhmer G,Merkelbach Sdoi
10.1016/0304-3940(90)90411-2subject
Has Abstractpub_date
1990-08-14 00:00:00pages
204-9issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(90)90411-2journal_volume
116pub_type
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章,收录出版
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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