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Tyrosine hydroxylase-immunoreactive neurons in the human cerebral cortex: a novel catecholaminergic group?

Abstract：

:Tyrosine hydroxylase-like immunoreactive (TH-IR) neurons with morphological features of interneurons were found throughout the human cerebral cortex. Quantitative estimates in 14 different cytoarchitectonic areas revealed a specific regional distribution pattern, neurons being less dense in primary cortical areas and denser in higher order associative areas and some limbic related areas. A partial relationship was noted between the density of labeled neurons and that of the known dopaminergic innervation. The role of the cortical TH-IR neurons in catecholaminergic function, however, remains unclear since the presence of other catecholaminergic synthesizing enzymes, dopamine-beta-hydroxylase and DOPA decarboxylase, could not be demonstrated at their level. Similar neurons have been observed transiently in the rodent cortex during development; their persistence and topographical extension in the human brain warrants further study on their possible functional role.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Gaspar P,Berger B,Febvret A,Vigny A,Krieger-Poulet M,Borri-Voltattorni C

doi

10.1016/0304-3940(87)90464-2

subject

Has Abstract

pub_date

1987-10-05 00:00:00

pages

257-62

issue

3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(87)90464-2

journal_volume

80

pub_type

杂志文章

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