The butyrylcholinesterase gene is neither independently nor synergistically associated with late-onset AD in clinic- and community-based populations.

abstract：:By recording the locomotor activity rhythm of hagfish, Eptatretus burgeri, in which surgical lesions of the pretectal areas were made, we searched for the route of light information from the eyes to the circadian pacemaker, which is considered to be located in the preoptic nucleus. The entrainment of circadian activit...

journal_title：Neuroscience letters

authors： Ooka-Souda S,Kadota T,Kabasawa H,Takeuchi H

更新日期：1995-06-16 00:00:00

abstract：:In neuro-inflammatory diseases, activated T cells are thought to drive the inflammatory process. In this study, we investigated the potential role of three T cell attracting chemokines (CK) in neuro-inflammation. For this purpose, we measured levels of CXCL16, CCL17 and CCL18 in matched serum and cerebrospinal fluid (...

journal_title：Neuroscience letters

authors： le Blanc LM,van Lieshout AW,Adema GJ,van Riel PL,Verbeek MM,Radstake TR

更新日期：2006-04-10 00:00:00

abstract：:To verify the hypothesis that the control of movement by the cortical masticatory area (CMA) is particularly important at the beginning of the mastication, we compared movements before and after bilateral CMA ablation. After ablation, the animal could not manipulate food placed in the front of the mouth for several da...

journal_title：Neuroscience letters

authors： Enomoto S,Schwartz G,Lund JP

更新日期：1987-11-23 00:00:00

abstract：:The dentate gyrus of the hippocampus is one of few regions in the adult mammalian brain characterized by ongoing neurogenesis. It has been demonstrated that Noggin antagonizes bone morphogenetic protein-4 (BMP4) to create a niche for subventricular zone neurogenesis. We previously demonstrated that Noggin and BMP4 sho...

journal_title：Neuroscience letters

authors： Fan XT,Xu HW,Cai WQ,Yang H,Liu S

更新日期：2004-08-05 00:00:00

abstract：:The induction of heme oxygenase-1 (HO-1), the 32 kDa heat shock protein, was examined in the traumatized rat brain. At 24 h after either mild or severe brain injury or sham surgery, HO-1 was immunolocalized in fixed sections of brain. After mild brain injury, hemorrhage was apparent in the subarachnoid space, external...

journal_title：Neuroscience letters

authors： Fukuda K,Panter SS,Sharp FR,Noble LJ

更新日期：1995-10-20 00:00:00

abstract：:Effects of anxiety on perceptual-motor organisation of rhythmical forearm movements were examined using an interrupted time series design with staggered baselines. Participants were exposed to repeated baseline sessions interrupted with two anxiety-inducing sessions. Results showed that under moderate levels of anxiet...

journal_title：Neuroscience letters

authors： Court ML,Bennett SJ,Williams AM,Davids K

更新日期：2005-08-12 00:00:00

abstract：:IgGs from two LEMS patients applied to human neuroblastoma IMR32 cells reduced the density of low- (LVA; T) and high-threshold (HVA; L and N) Ba2+ currents by different percentages: 36% (LVA) and 56% (HVA) for one and 48% and 45% for the other. A pharmacological assay of IgGs action based on the block of L-type channe...

journal_title：Neuroscience letters

authors： Grassi C,Magnelli V,Carabelli V,Sher E,Carbone E

更新日期：1994-11-07 00:00:00

abstract：:In striatal neurons in primary culture quisqualate potently stimulated the formation of inositol phosphates via a metabotropic receptor we recently termed Qp in order to distinguish it from the classical ionotropic quisqualate receptor termed Qi. Here we show that 10 microM of quisqualate activated in a rapid and tran...

journal_title：Neuroscience letters

authors： Manzoni OJ,Finiels-Marlier F,Sassetti I,Blockaert J,le Peuch C,Sladeczek FA

更新日期：1990-02-05 00:00:00

abstract：:FOXP2, the first gene known to be involved in the development of speech and language, can be considered to be, a priori, a candidate gene in schizophrenia, given the mounting evidence that the underlying core deficit in this disease could be a failure of structures relevant to normal language processing. To investigat...

journal_title：Neuroscience letters

authors： Španiel F,Horáček J,Tintěra J,Ibrahim I,Novák T,Čermák J,Klírová M,Höschl C

更新日期：2011-04-15 00:00:00

abstract：:Freezing is one of the most widely recognized defensive reactions to approaching threats in animals. Here we tested whether the same stimuli can elicit freeze-like responses in healthy humans as well. We used a modified version of the two-frame apparent motion paradigm, in which both size and location of a stimulus wi...

journal_title：Neuroscience letters

authors： Sagliano L,Cappuccio A,Trojano L,Conson M

更新日期：2014-02-21 00:00:00

abstract：:Small iontophoretic applications of wheat germ agglutinin-conjugated to horseradish peroxidase have been used to simultaneously observe, in the rat, the afferent and efferent connections of small parabrachial subregions in the same animal. The results demonstrate that a restricted region centered on the external porti...

journal_title：Neuroscience letters

authors： Bernard JF,Peschanski M,Besson JM

更新日期：1989-05-22 00:00:00

abstract：:CART peptides are important neurotransmitters, but little is known about their receptors or signaling pathways in cells. In this study we describe the effects of CART 55-102 on the stimulation of extracellular signal-related kinase (ERK) in a pituitary-derived cell line. CART 55-102 treatment resulted in markedly enha...

journal_title：Neuroscience letters

authors： Lakatos A,Prinster S,Vicentic A,Hall RA,Kuhar MJ

更新日期：2005-08-12 00:00:00

abstract：:Advanced glycation end products (AGEs) in the brain were immunohistochemically examined in Alzheimer's disease (AD) and aging using anti-AGE antibody recognizing mainly carboxymethyllysine. AGE positive staining diffusely located in the neuronal perikarya of hippocampus and parahippocampus in AD and aged brains withou...

journal_title：Neuroscience letters

authors： Takedo A,Yasuda T,Miyata T,Mizuno K,Li M,Yoneyama S,Horie K,Maeda K,Sobue G

更新日期：1996-12-27 00:00:00

abstract：:The individual biological activities of many neurotrophic factors and their variants, which are produced by alternative splicing and proteolytic processing, often remain to be characterized. Bacterial protein production combined with protein refolding and purification is a conventional procedure to obtain active neuro...

journal_title：Neuroscience letters

authors： Wang R,Iwakura Y,Araki K,Sotoyama H,Takei N,Nawa H

更新日期：2011-06-22 00:00:00

abstract：:The nucleus raphe magnus belongs to the thermoafferent system. Following iontophoretic choleratoxin b injections in its rostral part, a substantial to large number of anterogradely labeled varicose fibres were observed in the medial and lateral preoptic areas, the bed nucleus, the substantia innominata, the ventral pa...

journal_title：Neuroscience letters

authors： Hermann DM,Luppi PH,Peyron C,Hinckel P,Jouvet M

更新日期：1996-10-04 00:00:00

abstract：:Human nerve growth factor (NGF) serum concentrations were measured in a healthy sample of 126 participants by a modified highly sensitive and specific two-site enzyme immunoassay. The measured NGF concentrations differ considerably from a normal distribution. The median NGF concentration was 19.68 pg/ml with an interq...

journal_title：Neuroscience letters

authors： Lang UE,Gallinat J,Danker-Hopfe H,Bajbouj M,Hellweg R

更新日期：2003-06-19 00:00:00

abstract：:Although the coadministration of lidocaine with propranolol interferes with the metabolic profile (pharmacokinetics), its pharmacodynamics is still unclear. In this report, we investigate whether propranolol can potentiate the effect of lidocaine. Rats received spinal anesthesia with lidocaine co-injected with propran...

journal_title：Neuroscience letters

authors： Chen YW,Chu CC,Chen YC,Hung CH,Li YT,Wang JJ

更新日期：2011-09-26 00:00:00

abstract：:Oxidative stress is considered important for the pathogenesis of Alzheimer disease (AD), which is characterized by the formation of senile plaques rich in amyloid beta-protein (Abeta). Abeta cytotoxicity has been found dependent on lysosomes, which are abundant in AD neurons and are shown to partially co-localize with...

journal_title：Neuroscience letters

authors： Zheng L,Roberg K,Jerhammar F,Marcusson J,Terman A

更新日期：2006-02-20 00:00:00

abstract：:Mutations in DJ-1 cause familial Parkinson's disease (PD). The expression pattern of DJ-1 in the brain remains controversial. In the present study, we used DJ-1 deficient mice as negative controls and examined DJ-1 mRNA expression in mouse brains. In sequential double labeling on the same sections, in situ hybridizati...

journal_title：Neuroscience letters

authors： Xie Z,Zhuang X,Chen L

更新日期：2009-11-20 00:00:00

abstract：:The high-affinity, sodium-dependent uptake of dopamine (DA) was inhibited by the pretreatment of synaptosomes with neuraminidase from Vibrio cholerae. The inhibition was of a non-competitive type, resulting in a 40% decrease of Vmax. Neither basal nor depolarization-stimulated release of DA was affected. Treatment of ...

journal_title：Neuroscience letters

authors： Zaleska MM,Erecińska M

更新日期：1987-11-10 00:00:00

abstract：:The mechanisms responsible for the termination of paroxysmal depolarization shifts (PDS) were studied with intracellular recordings on CA1 neurons of rat hippocampal slices. Epileptiform activity was induced by application of penicillin, bicuculline or Mg-free artificial cerebrospinal fluid (ACSF). PDS in penicillin-c...

journal_title：Neuroscience letters

authors： Domann R,Westerhoff CH,Witte OW

更新日期：1994-07-18 00:00:00

abstract：:The molecular regulation of seizure-induced neuronal death may involve interactions between proteins of the Bcl-2 and 14-3-3 families. To further examine these pathways we performed subcellular fractionation on hippocampi obtained following a brief period of status epilepticus in the rat. Western blotting determined s...

journal_title：Neuroscience letters

authors： Schindler CK,Shinoda S,Simon RP,Henshall DC

更新日期：2004-02-19 00:00:00

abstract：:The fate of neural stem/progenitor cells (NSCs/NPCs) in vivo lies on the local microenvironment. Whether the denervated hippocampus provides a stimulative role on the survival and differentiation of the anterior subventricular zone (SVZa) progenitors was investigated in the present study. In vivo the SVZa progenitors ...

journal_title：Neuroscience letters

authors： Zhang X,Jin G,Tian M,Qin J,Huang Z

更新日期：2007-03-06 00:00:00

abstract：:Interleukin-6 (IL-6) has been shown to have potent neurotrophic activity on peripheral and central neurons in vitro. However, it remains to be determined whether or not IL-6 rescues hippocampal CA1 neurons from lethal ischemia and prevents ischemia-induced learning disability. In the present in vivo study, we infused ...

journal_title：Neuroscience letters

authors： Matsuda S,Wen TC,Morita F,Otsuka H,Igase K,Yoshimura H,Sakanaka M

更新日期：1996-02-02 00:00:00

abstract：:In the present study we sought to investigate the signal transduction mechanisms that underlie the alpha2-adrenergic receptor (AR)-induced, subtype-specific neuronal differentiation of PC12 cells. Alpha2-ARs induced NF-kappaB transcriptional activity and p21(waf-1) gene transcription in the same subtype-specific manne...

journal_title：Neuroscience letters

authors： Lymperopoulos A,Karkoulias G,Koch WJ,Flordellis CS

更新日期：2006-07-24 00:00:00

abstract：:The possibility that zinc (Zn2+) induces giant depolarizing potentials (GDPs) by blocking pre- and postsynaptic gamma-aminobutyric acidB (GABAB) receptors in area CA1 of rat hippocampal slices was investigated. Monosynaptic GABAA receptor-mediated fast and GABAB receptor-mediated late inhibitory postsynaptic potential...

journal_title：Neuroscience letters

authors： Lambert NA,Levitin M,Harrison NL

更新日期：1992-02-03 00:00:00

abstract：:Tumor related contralateral motor deficits complicate preoperative functional magnetic resonance imaging (fMRI). In plegic patients the localization of the sensorimotor cortex is often impossible. In this context we developed a clinical fMRI protocol dedicated to patients with motor deficits using the unaffected ipsil...

journal_title：Neuroscience letters

authors： Stippich C,Kapfer D,Hempel E,Borgulya G,Bongers A,Heiland S,Sartor K

更新日期：2000-05-12 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Neuroscience letters

authors： Wang JJ,Li QS,Li Y,Zheng YR

更新日期：2011-05-06 00:00:00

abstract：:Oxytocin (OT) modulation of synaptic transmission between olfactory bulb neurones has been implicated in the induction of maternal behaviour, but the mechanism of action is unknown. We examined the action of OT on gamma-aminobutyric acid(A) (GABA(A)) receptor-mediated spontaneous inhibitory postsynaptic currents (sIPS...

journal_title：Neuroscience letters

authors： Osako Y,Otsuka T,Taniguchi M,Oka T,Kaba H

更新日期：2000-07-28 00:00:00

abstract：:The occurrence and distribution of nociceptin, a 17-amino acid peptide with structural similarity to dynorphin A, and its receptor, opioid receptor-like-1 (ORL1) receptor, were investigated in the guinea-pig sympathetic nervous system by means of immunohistochemistry and reverse transcription-polymerase chain reaction...

journal_title：Neuroscience letters

authors： Kummer W,Fischer A

更新日期：1997-09-26 00:00:00