Abstract:
:The high-affinity, sodium-dependent uptake of dopamine (DA) was inhibited by the pretreatment of synaptosomes with neuraminidase from Vibrio cholerae. The inhibition was of a non-competitive type, resulting in a 40% decrease of Vmax. Neither basal nor depolarization-stimulated release of DA was affected. Treatment of synaptosomes with neuraminidase caused a 48% loss of sialic acid from the lipid-bound pool and a 80% decrease in the protein-bound fraction. The inhibition of DA uptake was found to be related linearly to the loss of sialic acid from the protein pool. It is postulated that a sialic acid moiety is involved in DA transport across the synaptosomal membrane.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Zaleska MM,Erecińska Mdoi
10.1016/0304-3940(87)90179-0subject
Has Abstractpub_date
1987-11-10 00:00:00pages
107-12issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(87)90179-0journal_volume
82pub_type
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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