Abstract:
:In non-diabetic mice, s.c. injection of formalin to the hindpaw had a biphasic effect: an immediate nociceptive response (first-phase) followed by a tonic response (second-phase). However, only the immediate nociceptive response was observed in diabetic mice. The duration of the first-phase response was significantly longer in diabetic mice than in non-diabetic mice. In diabetic mice, when spantide, an antagonist of substance P, reduced the duration of the nociceptive response in the first-phase to the levels that were observed in non-diabetic mice, the second-phase response appeared. The second phase also became apparent in diabetic mice after pretreatment with naltrindole (3 mg/kg), an antagonist of delta-opioid receptors. These results suggest that a negative control system, which is mediated by delta-opioid receptors and links substance P with somatostatin-mediated nociceptive transmission, may inhibit the formalin-induced second-phase of the nociceptive response in diabetic mice.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Kamei J,Hitosugi H,Kasuya Ydoi
10.1016/0304-3940(93)90761-9subject
Has Abstractpub_date
1993-01-12 00:00:00pages
161-4issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(93)90761-9journal_volume
149pub_type
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