Abstract:
:Neuroglobin (Ngb) is a novel vertebrate globin expressed principally in neurons. Ngb expression is induced by hypoxia and ischemia, and Ngb protects neurons against these insults. The mechanism of Ngb's protective action is unknown, but its ability to bind NO suggests that NO scavenging might be involved. To test this hypothesis, we treated wild type and Ngb-transfected HN33 (mouse hippocampal neuronxN18TG2 neuroblastoma) cells with NO donors and compared their sensitivity to NO-induced cell death. Ngb overexpression shifted concentration-toxicity curves to the right, indicating reduced susceptibility to NO or is metabolites. The results suggest that the ability of Ngb to neutralize the neurotoxic effects of reactive nitrogen species may be an important contributor to its neuroprotective properties.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Jin K,Mao XO,Xie L,Khan AA,Greenberg DAdoi
10.1016/j.neulet.2007.10.031subject
Has Abstractpub_date
2008-01-10 00:00:00pages
135-7issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(07)01145-7journal_volume
430pub_type
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journal_title:Neuroscience letters
pub_type: 杂志文章
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