Neuroglobin protects against nitric oxide toxicity.

Abstract:

:Neuroglobin (Ngb) is a novel vertebrate globin expressed principally in neurons. Ngb expression is induced by hypoxia and ischemia, and Ngb protects neurons against these insults. The mechanism of Ngb's protective action is unknown, but its ability to bind NO suggests that NO scavenging might be involved. To test this hypothesis, we treated wild type and Ngb-transfected HN33 (mouse hippocampal neuronxN18TG2 neuroblastoma) cells with NO donors and compared their sensitivity to NO-induced cell death. Ngb overexpression shifted concentration-toxicity curves to the right, indicating reduced susceptibility to NO or is metabolites. The results suggest that the ability of Ngb to neutralize the neurotoxic effects of reactive nitrogen species may be an important contributor to its neuroprotective properties.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Jin K,Mao XO,Xie L,Khan AA,Greenberg DA

doi

10.1016/j.neulet.2007.10.031

subject

Has Abstract

pub_date

2008-01-10 00:00:00

pages

135-7

issue

2

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(07)01145-7

journal_volume

430

pub_type

杂志文章
  • The glossopharyngeal nerve of the axolotl labeled with carbocyanine dye (diI).

    abstract::Fluorescent carbocyanine dye (diI) was used to label the glossopharyngeal (IX) nerve in the fixed preparation of the Mexican salamander, axolotl. When the cell bodies were viewed with a confocal laser scanning microscope and Nomarski optics, the cytoplasm was brightly fluorescent, but not the cell nucleus. The cell bo...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90352-t

    authors: Nagai T,Oka Y

    更新日期:1991-09-30 00:00:00

  • Role of alpha 1 and alpha 2-adrenoceptors of the lateral hypothalamic area on urinary excretion caused by centrally administered angiotensin II.

    abstract::To determine whether central alpha 1 and alpha 2-adrenergic mechanisms are involved in urinary sodium and potassium excretion and urine volume induced by angiotensin II (ANGII), these renal parameters were measured in volume-expanded Holtzman rats with cannulas implanted into lateral ventricle (LV) and lateral hypotha...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(95)11751-h

    authors: Saad WA,Camargo LA,Renzi A,Menani JV,Saad WA

    更新日期:1995-07-21 00:00:00

  • Does the medial thalamus play a role in the negative affective component of visceral pain in rats?

    abstract::Pain consists of sensory and negative affective components. Using a conditioned place aversion (CPA) paradigm, we investigated whether the medial thalamus (MT) played a role in the affective component of visceral pain induced by intraperitoneal injection of acetic acid into male Long-Evan rats. Acetic acid produced wr...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2007.04.064

    authors: Wang HC,Chai SC,Wu YS,Wang CC

    更新日期:2007-06-08 00:00:00

  • Postischemic expression of P-selectin immunoreactivity in rat brain.

    abstract::Change of immunoreactive P-selectin was examined in rat brain after transient middle cerebral artery (MCA) occlusion (O) with anti-P-selectin monoclonal antibody using brain samples of sham control and after ischemia. Temporal, spatial, and cellular changes of immunohistochemical expressions of P-selectin were evaluat...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(97)00385-6

    authors: Suzuki H,Abe K,Tojo S,Morooka S,Kimura K,Mizugaki M,Itoyama Y

    更新日期:1997-06-13 00:00:00

  • Thyrotropin-releasing hormone (TRH) degradation in NIH:N mouse cerebral cortex and spinal cord.

    abstract::Thyrotropin-releasing hormone (TRH) metabolism in NIH:N mouse cerebral cortex and spinal cord was studied with high pressure liquid chromatography. Degradation of added TRH was significantly (P less than 0.001) slower in the spinal cord (2.19 +/- 0.46%/min) than in the cerebral cortex (7.54 +/- 0.31%/min). Bacitracin,...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(86)90560-4

    authors: Schwartz TM,Turner JG,Brooks BR

    更新日期:1986-11-11 00:00:00

  • Butein inhibits NF-κB activation and reduces infiltration of inflammatory cells and apoptosis after spinal cord injury in rats.

    abstract::The IKK/NF-κB signalling pathway plays a predominant role in the regulation of inflammation and apoptosis in spinal cord injury (SCI). We have previously demonstrated that targeting of the IKK/NF-κB pathway improved the recovery of locomotor function by reducing the infiltration of inflammatory cells and apoptosis aft...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2013.03.004

    authors: Lu M,Wang S,Han X,Lv D

    更新日期:2013-05-10 00:00:00

  • Reversal properties of an EGTA-resistant late hyperpolarization that follows synaptic stimulation of hippocampal neurons.

    abstract::A late hyperpolarization (LH) which follows low level to moderate synaptic stimulation of neurons in the hippocampal formation neurons was previously shown to consist primarily of a potassium conductance. The present experiments showed that when extracellular cesium was present in order to reduce anamolous rectificati...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(84)90206-4

    authors: Thalmann RH

    更新日期:1984-04-20 00:00:00

  • Two-component models of reaching: evidence from deafferentation in a Fitts' law task.

    abstract::Both feedforward and feedback mechanisms are used to ensure accurate movements. Feedback information comes primarily from vision and proprioception; the relative contributions of these modalities to on-line control of action and internal model maintenance remain unclear. We report data from an experiment in which a ch...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2009.01.002

    authors: Medina J,Jax SA,Coslett HB

    更新日期:2009-02-27 00:00:00

  • Studies on the antinociceptive effect of [Nphe1]nociceptin(1-13)NH2 in mice.

    abstract::Nociceptin/orphanin FQ (NC) and its receptor (OP(4)) have been implicated in the regulation of various functions including nociception. [Nphe(1)]NC(1-13)NH(2) (Nphe) is a selective OP(4) antagonist which prevents the pronociceptive effects of supraspinal NC and causes per se a naloxone-insensitive antinociceptive effe...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(01)02352-7

    authors: Di Giannuario A,Rizzi A,Pieretti S,Guerrini R,Bertorelli R,Salvadori S,Regoli D,Calo G

    更新日期:2001-12-04 00:00:00

  • TNF-alpha differentially modulates ion channels of nociceptive neurons.

    abstract::Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine involved in the development and maintenance of inflammatory and neuropathic pain conditions. The mechanisms by which TNF-alpha elicits pain behavior are still incompletely understood. Numerous studies suggest that TNF-alpha sensitizes primary affere...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2008.01.070

    authors: Czeschik JC,Hagenacker T,Schäfers M,Büsselberg D

    更新日期:2008-04-04 00:00:00

  • Enhancement of the synchronized firing of CA1 pyramidal cells by medial septum preconditioning: time-dependent involvement of muscarinic cholinoceptors and GABAB receptors.

    abstract::Activation of the medial septum (MS) enhances the synchronized firing of pyramidal cells in the hippocampus. At least two distinct mechanisms might be recruited in this process: GABAergic inhibition of hippocampal inhibitory interneurons and cholinergic enhancement of pyramidal cell excitability. In the present study,...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2005.09.035

    authors: Ovsepian SV

    更新日期:2006-01-23 00:00:00

  • Effects of irradiation on the sensitivity of melatonin release to norepinephrine in cultured pineal bodies of rats.

    abstract::We measured levels of basal and norepinephrine (NE) -induced melatonin release in cultured pineal bodies of rats just after and 2 days after irradiation (20 or 200 Gy) or sham-irradiation. On the day of irradiation, basal and NE-induced melatonin release were not affected by irradiation. Two days after irradiation, ba...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(00)00984-8

    authors: Saito K,Shinohara K,Morofushi M,Funabashi T,Mitsushima D,Hata M,Matsubara S,Kimura F

    更新日期:2000-04-21 00:00:00

  • Murine astrocytes are responsive to the pro-inflammatory effects of IL-20.

    abstract::Glia are key regulators of inflammatory responses within the central nervous system (CNS) following infection or trauma. We have previously demonstrated the ability of activated astrocytes to rapidly produce pro-inflammatory mediators followed by a transition to an anti-inflammatory cytokine production profile that in...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2019.134334

    authors: Burmeister AR,Johnson MB,Marriott I

    更新日期:2019-08-24 00:00:00

  • Structure and alternative splicing of the gene encoding alpha1G, a human brain T calcium channel alpha1 subunit.

    abstract::The structure of CACNA1G, the gene encoding alpha1G, a human brain T Ca2+ channel alpha1 subunit, was determined by comparison of polymerase chain reaction-amplified brain cDNA and genomic sequences. The gene consists of at least 38 exons, two of them newly-identified, spanning at least 66490 basepairs of chromosome 1...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(99)00716-8

    authors: Mittman S,Guo J,Agnew WS

    更新日期:1999-10-29 00:00:00

  • Localization of the glutamate transporter GLT-1 in rat and macaque monkey retinae.

    abstract::Antibodies directed against a glutamate transporter (GLT-1) purified from rat brain were applied to cryostat sections of rat and macaque monkey retinae. In the brain, GLT-1 expression is found mainly in astrocytes, and therefore it has been suggested that GLT-1 may be a glutamate transporter specific to glial cells. H...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(94)90375-1

    authors: Rauen T,Kanner BI

    更新日期:1994-03-14 00:00:00

  • Meningeal/vascular alterations and loss of extracellular matrix in the neurogenic zone of adult BTBR T+ tf/J mice, animal model for autism.

    abstract::Autism spectrum disorders are characterized by impaired social and communication skills and seem to result from altered neural development. We sought to determine whether the anatomy of the meninges and extracellular matrix (ECM) is altered in an animal model of autism, the BTBR T+ tf/J mouse. This mouse displays whit...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2011.05.014

    authors: Mercier F,Cho Kwon Y,Kodama R

    更新日期:2011-07-12 00:00:00

  • Forskolin mimics and blocks a serotonin-sensitive decreased K+ conductance in tail sensory neurons of Aplysia.

    abstract::Facilitation of synaptic connections between sensory neurons and motor neurons mediating the tail-withdrawal reflex in Aplysia is produced by sensitizing stimuli. These effects can be mimicked by perfusing the pleural and pedal ganglia of a semi-intact preparation with serotonin (5-HT). In addition to the synaptic fac...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(84)90342-2

    authors: Walsh JP,Byrne JH

    更新日期:1984-11-23 00:00:00

  • Effect of the histone deacetylase inhibitors on behavioural sensitization to a single morphine exposure in mice.

    abstract::Behavioural sensitization to a single morphine exposure has been considered to be a long-term form of behavioural plasticity associated with opioid addiction. Accumulated evidence has shown that histone modification plays a key role in behavioural plasticity. Therefore, this study was designed to investigate whether t...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2011.03.005

    authors: Jing L,Luo J,Zhang M,Qin WJ,Li YL,Liu Q,Wang YT,Lawrence AJ,Liang JH

    更新日期:2011-04-25 00:00:00

  • Absence of catecholamine uptake mechanism in the isolated perfused adrenal gland of the rat.

    abstract::The left adrenal gland of the rat was perfused in vitro via the adrenal vein with Krebs-bicarbonate solution to study accumulation of exogenous catecholamines and secretion of endogenous norepinephrine and epinephrine by exposing the gland to various sympathomimetic agents. Perfusions with high concentrations of norep...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(84)90476-2

    authors: Wakade AR,Wakade TD

    更新日期:1984-09-07 00:00:00

  • The effect of experimentally induced diabetes mellitus on the lipid order and composition of rat cerebral microvessels.

    abstract::To determine whether diabetes mellitus alters the lipid order and composition of cerebral microvessels, streptozotocin-induced diabetic rats were studied after 5 weeks of chronic hyperglycemia. Diabetes did not affect membrane order or the thermotropic transition temperature of cerebral microvessels as determined from...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(92)90007-t

    authors: Mooradian AD,Smith TL

    更新日期:1992-10-12 00:00:00

  • Differential effects of drug-induced ascorbic acid release in the striatum and nucleus accumbens of freely moving rats.

    abstract::Previous studies have shown that striatum and nucleus accumbens (NAc) are two different structures in mediating addictive drug-induced ascorbic acid (AA) release. In order to further characterize the different effects of drugs-induced AA release in the striatum and NAc, in the present study, we investigated the effect...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2006.01.022

    authors: Gu PF,Wu CF,Yang JY,Shang Y,Hou Y,Bi XL,Dai F

    更新日期:2006-05-15 00:00:00

  • A novel gene selectively expressed in the cerebellum.

    abstract::A cDNA clone encoding a novel protein (Cer-1) was isolated from a mouse cerebellar cDNA library. The deduced amino acid sequence of Cer-1 is not homologous to other sequences in the protein sequence data base. RNA blot analysis suggests that expression of Cer-1 RNA occurs selectively in the adult cerebellum and in pur...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(96)12628-8

    authors: Bulleit RF,Lin X,Jeppi JV

    更新日期:1996-05-10 00:00:00

  • Quantal behaviour of synaptic transmission can be statistically examined using the Fourier line spectrum of the histogram of synaptic potentials.

    abstract::A statistical approach to reveal the quantal behaviour of postsynaptic potentials (PSPs) is described. This includes: (1) obtaining the Fourier line spectrum (decomposition into harmonics) of the PSP histogram; and (2) testing the null hypothesis, 'the spectrum is that of white noise', using an ANOVA. The harmonic tha...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(93)90390-7

    authors: Rusakov DA

    更新日期:1993-12-12 00:00:00

  • Current source density distribution of sleep spindles in humans as found by synthetic aperture magnetometry.

    abstract::Previous magnetoencephalography (MEG) studies of sleep spindles have identified a complex and widespread distribution in parietal and frontal cortices by fitting a dipolar model to the data. In this study, we used a whole-head 151-channel MEG system with simultaneous electroencephalography (EEG) recording in eight nor...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(03)00048-x

    authors: Ishii R,Dziewas R,Chau W,Sörös P,Okamoto H,Gunji A,Pantev C

    更新日期:2003-04-03 00:00:00

  • Plasticity in the synaptic number associated with neuropathic pain in the rat spinal dorsal horn: A stereological study.

    abstract::This study aimed to determine whether neuropathic pain is associated with a plasticity change in the number of synapses in the spinal dorsal horn. 12 normal adult SD rats were randomly divided into two groups: 7 animals were subjected to unilateral loose ligation (to induce chronic constriction injury) of the sciatic ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2010.09.037

    authors: Peng B,Lin JY,Shang Y,Yang ZW,Wang YP

    更新日期:2010-12-03 00:00:00

  • Spontaneous openings of large and small conductance acetylcholine receptor channels in Xenopus myocytes.

    abstract::Spontaneous openings of acetylcholine receptor channels were investigated using Xenopus myotomal muscle cells in culture and patch clamp recording methods. Two classes of channels with conductances close to 40 and 60 pS and reversal potentials near 0 mV were found to open in the absence of agonist. The open time of th...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90092-8

    authors: Rojas L,Zuazaga C

    更新日期:1991-04-01 00:00:00

  • Mechanisms of presynaptic inhibition studied using paired-pulse facilitation.

    abstract::An investigation was made of the effect of presynaptic inhibition on paired-pulse facilitation (PPF) of group Ia afferent excitatory postsynaptic potentials (EPSPs). The main finding from this study was that PPF was enhanced during presynaptic inhibition of compound Ia EPSPs. This increase in PPF is identical to that ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90548-8

    authors: Stuart GJ,Redman SJ

    更新日期:1991-05-27 00:00:00

  • A possible spino (trigemino)-ponto-amygdaloid pathway for pain.

    abstract::Small iontophoretic applications of wheat germ agglutinin-conjugated to horseradish peroxidase have been used to simultaneously observe, in the rat, the afferent and efferent connections of small parabrachial subregions in the same animal. The results demonstrate that a restricted region centered on the external porti...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(89)90664-2

    authors: Bernard JF,Peschanski M,Besson JM

    更新日期:1989-05-22 00:00:00

  • Changes in dopamine release in caudate nuclei and substantia nigrae after electrical stimulation of the posterior interposate nucleus of cat cerebellum.

    abstract::The effect of unilateral electrical stimulation of the posterior interposate nucleus of the cerebellum was examined on the activity of the nigro-striatal dopaminergic pathways on both sides of the brain in alpha-chloralose anaesthetized cats. Push-pull cannulae were inserted into both caudate nuclei and both substanti...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(80)90079-8

    authors: Nieoullon A,Dusticier N

    更新日期:1980-04-01 00:00:00

  • Differential sensitivity of selected brain areas to excitatory amino acids.

    abstract::The 22Na+ efflux stimulated by selected agonists of the 4 excitatory amino acid receptors, previously detected in the striatum, has been studied on 22Na+-preloaded slices prepared from 10 major areas of the rat brain. All brain areas were found to be sensitive, albeit to varying extents, to excitatory amino acids. The...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(83)90468-8

    authors: Luini A,Goldberg O,Teichberg VI

    更新日期:1983-11-11 00:00:00