Involvement of the cellular prion protein in the migration of brain microvascular endothelial cells.

abstract：:We recently established adrenal medullary cell line tsAM5D, which was immortalized by use of a temperature-sensitive mutant of the oncogene simian virus 40 large T-antigen. In the present study, when co-treated with glial cell line-derived neurotrophic factor (GDNF) and ciliary neurotrophic factor (CNTF), tsAM5D cells...

journal_title：Neuroscience letters

authors： Murata T,Koide N,Tsuboi M,Kohno S,Hikita K,Kaneda N

更新日期：2008-06-13 00:00:00

abstract：:Remacemide is a potential anticonvulsant drug with an active metabolite, desglycinyl-remacemide (DGR). Both moieties have been reported to block neuronal Na(+) channels and the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor. The effects of remacemide and DGR on zero Mg(2+)/4-aminopyridine-induced epileptifo...

journal_title：Neuroscience letters

authors： Santangeli S,Sills GJ,Stone TW,Brodie MJ

更新日期：2002-03-15 00:00:00

abstract：:Sweetened diets share commonalities with drugs of abuse, but studies comparing behavioral effects of different sweeteners are lacking. Common table sugar produces rewarding and withdrawal effects in planarians. We postulated that Splenda and Equal would produce similar responses and used a tetrad of behavioral assays ...

journal_title：Neuroscience letters

authors： Ouyang K,Nayak S,Lee Y,Kim E,Wu M,Tallarida CS,Rawls SM

更新日期：2017-01-01 00:00:00

abstract：:Discrete brain structures were analysed for gamma-aminobutyric acid (GABA) and vasopressin content in normo- and hypotensive rats treated with the glutamic acid decarboxylase inhibitor, 3-mercaptopropionic acid (MPA) and the GABAA agonist muscimol. In the normotensive group treated with MPA only, the concentration of ...

journal_title：Neuroscience letters

authors： Magnusson A,Höglund U,Sjöquist M

更新日期：1989-07-03 00:00:00

abstract：:Infection of the snail Lymnaea stagnalis with the schistosome parasite Trichobilharzia ocellata results in inhibition of reproduction and in giant growth. Parasite-related effects on the neuroendocrine centres that control these processes were studied electrophysiologically. Haemolymph from infected snails reduced the...

journal_title：Neuroscience letters

authors： Hordijk PL,de Jong-Brink M,ter Maat A,Pieneman AW,Lodder JC,Kits KS

更新日期：1992-03-02 00:00:00

abstract：:Several lines of evidence suggest a physiological role for Cu2+ in regulating nervous system function. In the present study using whole-cell patch-clamp recording, Cu2+ greatly enhanced current activated by 10 microM ATP in the majority of rat nodose ganglion neurons. The enhancement was concentration-dependent betwee...

journal_title：Neuroscience letters

authors： Li C,Peoples RW,Weight FF

更新日期：1996-11-15 00:00:00

abstract：:Protein profiling of cerebrospinal fluid in Guillain-Barrè syndrome (GBS), an acute and immune-mediated disease affecting the peripheral nervous system, was performed by two-dimensional electrophoresis. Significant modulated spots in GBS patients vs. control groups (a group of multiple sclerosis patients and one of he...

journal_title：Neuroscience letters

authors： D'Aguanno S,Franciotta D,Lupisella S,Barassi A,Pieragostino D,Lugaresi A,Centonze D,D'Eril GM,Bernardini S,Federici G,Urbani A

更新日期：2010-11-12 00:00:00

abstract：:Rat myotubes were cultured with embryonic mouse spinal cord explants. After 4 days of co-culture, (miniature) endplate potentials, (M)EPPs, could be detected in 20-40% of the nerve-contacted myotubes. Polyclonal antibodies against the neural cell adhesion molecule N-CAM and monoclonal antibodies to its L2/HNK-1 carboh...

journal_title：Neuroscience letters

authors： Mehrke G,Jockusch H,Schachner M

更新日期：1987-08-05 00:00:00

abstract：:Parkin gene mutations are by far the most common mutations in both familial Parkinson's disease (PD) and sporadic PD. Approximately, 50% of parkin mutations is exon dosage mutations (i.e., deletions and duplications of entire exons). Here, we first established a MLPA assay for quick detection of parkin exon rearrangem...

journal_title：Neuroscience letters

authors： Guo JF,Dong XL,Xu Q,Li N,Yan XX,Xia K,Tang BS

更新日期：2015-09-14 00:00:00

abstract：:We tested whether the stimulation of acupoints in the same spinal segments could induce different central responses with functional magnetic resonance imaging (fMRI) study. Stimulation of acupoints ST36/SP6 (Zusanli/Sanyinjiao) or GB34/BL57 (Yanglingquan/Chengshan) both activated primary and secondary somatosensory ar...

journal_title：Neuroscience letters

authors： Zhang WT,Jin Z,Luo F,Zhang L,Zeng YW,Han JS

更新日期：2004-01-02 00:00:00

abstract：:Acute stress can provoke apoptosis of the retina cells, and up-regulation of calcitonin gene related peptide (CGRP) in retina. However the role of CGRP in the pathology of the stress induced apoptosis of the retina cells is still elusive. The aim of this study was to investigate the endogenous of CGRP on retinal cell ...

journal_title：Neuroscience letters

authors： Yang JH,Zhang YQ,Guo Z

更新日期：2011-08-26 00:00:00

abstract：:Deficit in balance control is a common and often an initial disabling symptom of multiple sclerosis (MS). The aim of the study was to investigate the organization of anticipatory and compensatory postural adjustments in individuals with MS dealing with external perturbations. Ten individuals with MS and ten age-and-ge...

journal_title：Neuroscience letters

authors： Aruin AS,Kanekar N,Lee YJ

更新日期：2015-03-30 00:00:00

abstract：:Badminton players of varying skill levels viewed normal and point-light video clips of opponents striking the shuttle towards the viewer; their task was to predict in which quadrant of the court the shuttle would land. In a whole-brain fMRI analysis we identified bilateral cortical networks sensitive to the anticipati...

journal_title：Neuroscience letters

authors： Wright MJ,Bishop DT,Jackson RC,Abernethy B

更新日期：2011-08-18 00:00:00

abstract：:MicroRNAs (miRs) are endogenous small RNAs that regulate gene expression at the post-transcriptional level by mediating mRNA degradation or transcriptional inhibition. MiRs were implicated in the pathogenesis of numerous neurodegenerative diseases, including Parkinson's disease (PD). In this study we analyzed the poss...

journal_title：Neuroscience letters

authors： Lungu G,Stoica G,Ambrus A

更新日期：2013-10-11 00:00:00

abstract：:Gelsolin (GSN) levels and matrix metalloproteinase 3 (MMP3) activity have been found to be altered in the plasma in patients with Alzheimer disease (AD). The aim of this study was to determine whether a combination of these proteins with clinical data is specific and sensitive enough for AD diagnosis. In 113 non-demen...

journal_title：Neuroscience letters

authors： Peng M,Jia J,Qin W

更新日期：2015-05-19 00:00:00

abstract：BACKGROUND AND PURPOSE:Studies demonstrated that oxidative damage decreased intracellular ATP level in astrocytes. However, the pathway mediated ATP level decrease is obscure. Our previous study found intracellular ATP could be released via lysosome exocytosis in astrocytes. Here, we explored whether lysosome exocytosi...

journal_title：Neuroscience letters

authors： Li Z,Gu Y,Wen R,Shen F,Tian HL,Yang GY,Zhang Z

更新日期：2019-07-13 00:00:00

abstract：:Triazolam can shift the phase of circadian rhythms in hamsters recorded in constant light or dark. This effect is apparently mediated by physical activity stimulated by the drug. We examined whether triazolam can shift the phase of circadian rhythms in a diurnal primate, the squirrel monkey, that is sedated by triazol...

journal_title：Neuroscience letters

authors： Mistlberger RE,Houpt TA,Moore-Ede MC

更新日期：1991-03-11 00:00:00

abstract：:In vivo differential pulse voltammetry with carbon fiber electrodes was used to monitor extracellular 5-hydroxyindoleacetic acid (5-HIAA) levels in a serotonergic denervated target area, the striatum, before and after transplantation of mesencephalic raphé nuclei into the lateral ventricle in the rat. The amplitude of...

journal_title：Neuroscience letters

authors： McRae-Degueurce A,Serrano A,Sandillon F,Privat A,Scatton B

更新日期：1984-07-27 00:00:00

abstract：:The whole-cell configuration of the patch-clamp technique was applied to porcine pars intermedia cells. A tetrodotoxin-sensitive sodium current was recorded. Three types of calcium current were observed. Depolarizations from a holding potential of 100 mV elicited a transient current (ICaT), whereas depolarizations fro...

journal_title：Neuroscience letters

authors： Taleb O,Trouslard J,Demeneix BA,Feltz P

更新日期：1986-05-06 00:00:00

abstract：:Chronic demyelination and the concomitant loss of trophic support and increased energy demands in axons are thought to contribute to neurodegeneration in a number of neurological diseases such as multiple sclerosis (MS). Adult oligodendrocyte precursor cells (OPCs) play an important role in these demyelinating disease...

journal_title：Neuroscience letters

authors： Harrington EP,Bergles DE,Calabresi PA

更新日期：2020-01-10 00:00:00

abstract：:The influence of chronic arthritic pain upon the levels of mRNA encoding prodynorphin (mRNADYN) in the spinal cord of rats was evaluated by use of the RNA blot technique. Rats were rendered arthritic by inoculation of the tail-base with a suspension of Mycobacterium butyricum. Three weeks post inoculation, levels of m...

journal_title：Neuroscience letters

authors： Höllt V,Haarmann I,Millan MJ,Herz A

更新日期：1987-01-02 00:00:00

abstract：:The strength of feedforward inhibition was assessed in the CA1 region of in vitro hippocampus of benzodiazepine tolerant rats 2 and 7 days after 1 week oral flurazepam (FZP) administration. Feedforward inhibition was activated with a Schaffer collateral stimulation just-subthreshold for a population spike followed at ...

journal_title：Neuroscience letters

authors： Zeng X,Xie XH,Tietz EI

更新日期：1994-05-23 00:00:00

abstract：:Ovariectomy in the rat abolishes alpha-bungarotoxin (alpha-BTX) binding within the suprachiasmatic nucleus (SCN), a putative circadian pacemaker, and markedly reduces cholinergic activation of SCN cells. Circadian rhythms of running wheel activity were monitored continuously in intact male and female and chronically o...

journal_title：Neuroscience letters

authors： Mistlberger RE,Rusak B

更新日期：1986-12-23 00:00:00

abstract：:We aimed to evaluate the effects of l-dopa use on apparent diffusion coefficient (ADC) values of different brain regions in Parkinson's disease (PD) patients. Thirty-five subjects underwent magnetic resonance imaging (MRI), including 21 PD patients (13 men, 8 women; mean age, 63 years+/-8), and 14 sex and age-matched ...

journal_title：Neuroscience letters

authors： Degirmenci B,Yaman M,Haktanir A,Albayrak R,Acar M,Caliskan G

更新日期：2007-04-18 00:00:00

abstract：:A previous study of brain activation in normal subjects during a phonological (Phonemes) task and a lexical semantic (Words) task using positron-emission tomography [3] is complemented by new data after a method for image realignment was applied [17]. The pattern of cerebral blood flow increases associated with Words ...

journal_title：Neuroscience letters

authors： Démonet JF,Price C,Wise R,Frackowiak RS

更新日期：1994-11-21 00:00:00

abstract：:Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) may be effective in treating depression. Parental verbal abuse has been linked to decreased fractional anisotropy (FA) of white matter and reduced FA correlated with depression and anxiety scores. Utilizing a nonhuman primate model of moo...

journal_title：Neuroscience letters

authors： Coplan JD,Abdallah CG,Tang CY,Mathew SJ,Martinez J,Hof PR,Smith EL,Dwork AJ,Perera TD,Pantol G,Carpenter D,Rosenblum LA,Shungu DC,Gelernter J,Kaffman A,Jackowski A,Kaufman J,Gorman JM

更新日期：2010-08-16 00:00:00

abstract：:Astrocyte cell cultures were established from human fetal brains and exposed to human recombinant tumor necrosis factor alpha (TNF alpha) and human recombinant interferon gamma (IFN gamma), and the proliferative response was assessed by bromodeoxyuridine-immunostaining technique. TNF alpha showed an inhibitory activit...

journal_title：Neuroscience letters

authors： Moretto G,Yoo A,Kim SU

更新日期：1993-03-05 00:00:00

abstract：:The influence of transient forebrain ischemia on the temporal alteration of NMDA receptor (NMDAR1) mRNAs in the hippocampal formation was analysed by in situ hybridization, RNA blot and in vitro receptor autoradiography ([3H]3-((+)2-carboxypiperazin-4-yl)-propyl-1- phosphonic acid). In the CA1 subfield of the hippocam...

journal_title：Neuroscience letters

authors： Sugimoto A,Takeda A,Kogure K,Onodera H

更新日期：1994-03-28 00:00:00

abstract：:Neuron number and volume of the recently described vasopressin and oxytocin containing nucleus (VON) in the pig hypothalamus have been studied into adulthood. Following a 2.5-fold increase in both sexes around puberty, both neuron number and volume of the VON continued to increase in the female pig between 1 and 2.5 y...

journal_title：Neuroscience letters

authors： van Eerdenburg FJ,Swaab DF

更新日期：1991-10-28 00:00:00

abstract：:Removal of glutamate from the synaptic cleft by astroglial glutamine synthase (GS) is a crucial step in the regulation of glutamate turnover and metabolism, thus participating in endogenous neuroprotective processes occurring within brain tissues. Here we investigated on the effect of inflammatory cytokines on GS acti...

journal_title：Neuroscience letters

authors： Muscoli C,Visalli V,Colica C,Nisticò R,Palma E,Costa N,Rotiroti D,Nisticò G,Mollace V

更新日期：2005-01-20 00:00:00