The benzodiazepine triazolam phase-shifts circadian activity rhythms in a diurnal primate, the squirrel monkey (Saimiri sciureus).

Abstract:

:Triazolam can shift the phase of circadian rhythms in hamsters recorded in constant light or dark. This effect is apparently mediated by physical activity stimulated by the drug. We examined whether triazolam can shift the phase of circadian rhythms in a diurnal primate, the squirrel monkey, that is sedated by triazolam. Single injections of triazolam at 0.15-0.20 mg/kg induced phase advances or delays of monkey activity rhythms recorded in constant light. The phase-response curve is similar to that obtained for hamsters. Behavioral activation is evidently not necessary for a phase-shifting action of triazolam in this primate. A companion study in which triazolam was administered to squirrel monkeys in the dark in a light-dark cycle reentrainment paradigm failed to find evidence for a phase shifting action of triazolam. Shifts induced by triazolam in monkeys recorded in constant light may thus reflect changes in light exposure as a consequence of sedation or altered retinal processing of light.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Mistlberger RE,Houpt TA,Moore-Ede MC

doi

10.1016/0304-3940(91)90814-a

subject

Has Abstract

pub_date

1991-03-11 00:00:00

pages

27-30

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(91)90814-A

journal_volume

124

pub_type

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