Abstract：
:A culture of peripheral nerve cells enriched in Schwann cells was obtained from sciatic nerve in normal and demyelinating trembler mutant. These cells incorporated and metabolized a non-physiological trans fatty acid (elaidic aid) as well as the physiological cis isomer (oleic acid). Both acids were incorporated similarly in all lipids studied (phosphatidylcholine was a very potent acceptor) only cholesterol-esters' formation was slightly reduced from elaidic acid. Both acids were partially degradates into sub-units, in turn used for synthesis of new fatty acids. However elaidic acid was less degraded by the cells thus providing more C14:1, C16:1 fatty acids and less cholesterol. The sub-units were also used to provide very long chains, saturated and mono-unsaturated; only synthesis of nervonic acid was at variance when using oleic and elaidic acids. The presence of elaidic acid diminished the elongation-desaturation of essential fatty acids. No major differences were found between control and trembler cells, however cholesterol-esters' synthesis was slightly enhances in the mutant cells, when using both acids.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Bourre JM,Boutry JM,Masson M,Hauw JJdoi
10.1016/0304-3940(82)90292-0subject
Has Abstractpub_date
1982-05-28 00:00:00pages
173-8issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(82)90292-0journal_volume
30pub_type
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