Synthesis of apolipoprotein E (ApoE) mRNA by human neuronal-type SK N SH-SY 5Y cells and its regulation by nerve growth factor and ApoE.

abstract：:Repeated stress triggers a wide range of adaptive changes in the central nervous system including the elevation of serotonin (5-HT) metabolism and an increased susceptibility to affective disorders. To begin to examine whether these changes are mediated by alterations in gene expression for tryptophan hydroxylase (TPH...

journal_title：Neuroscience letters

authors： Chamas F,Serova L,Sabban EL

更新日期：1999-06-04 00:00:00

abstract：:The actions of acridinic acid (2,3-quinoline dicarboxylic acid), a new derivative of quinolinic acid, as an antagonist of amino acid-induced excitations are described. Acridinate, like kynurenate, in the cerebral cortex reduced the effects of all amino acids equally, but in the spinal cord was significantly less activ...

journal_title：Neuroscience letters

authors： Curry K,Magnuson DS,McLennan H,Peet MJ

更新日期：1986-05-06 00:00:00

abstract：:MicroRNA-146a (miRNA-146a) is an inducible, 22 nucleotide, small RNA over-expressed in Alzheimer's disease (AD) brain. Up-regulated miRNA-146a targets several inflammation-related and membrane-associated messenger RNAs (mRNAs), including those encoding complement factor-H (CFH) and the interleukin-1 receptor associate...

journal_title：Neuroscience letters

authors： Li YY,Cui JG,Dua P,Pogue AI,Bhattacharjee S,Lukiw WJ

更新日期：2011-07-20 00:00:00

abstract：:Argiotoxin636, a component of the spider venom of argiope species, was chemically synthesized together with a number of derivatives in order to analyse their blocking activity on mammalian glutamate receptors. Xenopus laevis oocytes injected with rat brain mRNA served as assay system. The results showed that argiotoxi...

journal_title：Neuroscience letters

authors： Draguhn A,Jahn W,Witzemann V

更新日期：1991-11-11 00:00:00

abstract：:Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are chemogenetic tools commonly-used to manipulate brain activity. The most widely-used synthetic DREADD ligand, clozapine-N-oxide (CNO), is back-metabolized to clozapine which can itself activate endogenous receptors. Studies in non-DREADD-expressin...

journal_title：Neuroscience letters

authors： Tran FH,Spears SL,Ahn KJ,Eisch AJ,Yun S

更新日期：2020-11-20 00:00:00

abstract：:Alzheimer disease (AD) is the most common type of dementia, and is currently incurable. The efficacy of existing treatments for AD such as acetylcholinesterase inhibitors is limited to symptom improvement. Research on disease-modifying therapies (DMTs) has conventionally focused on amelioration of CNS pathogenesis. Tw...

journal_title：Neuroscience letters

authors： Shozawa H,Oguchi T,Tsuji M,Yano S,Kiuchi Y,Ono K

更新日期：2018-06-11 00:00:00

abstract：:In the present study, an excitatory amino acid (EAA) pathway in the spinal cord which maintains sympathetic vasomotor tone in conscious rats has been investigated. To this end, the cardiovascular effects of an intrathecally administered EAA antagonist, kynurenate (KYN), were studied in conscious rats. KYN (0.5 mumol i...

journal_title：Neuroscience letters

authors： Verberne AJ,Widdop RE,Maccarrone C,Jarrott B,Beart PM,Louis WJ

更新日期：1990-07-13 00:00:00

abstract：:Spatial memory is coordinated with different brain regions especially hippocampus (HIP) and medial prefrontal cortex (mPFC). Influence of noise stress on working and reference memory error in rats was evaluated by radial eight-arm maze experiment. Changes in the dendritic count were observed in the brain regions such ...

journal_title：Neuroscience letters

authors： Manikandan S,Padma MK,Srikumar R,Jeya Parthasarathy N,Muthuvel A,Sheela Devi R

更新日期：2006-05-15 00:00:00

abstract：:Sickle cell disease (SCD) describes a group of disorders associated with a point mutation in the beta chain of hemoglobin. The mutation leads to the creation of sickle hemoglobin (HbS) and causes distortion of erythrocytes through polymerization under low oxygen, resulting in characteristic sickle red blood cells. Vas...

journal_title：Neuroscience letters

authors： Uhelski ML,Simone DA

更新日期：2019-07-13 00:00:00

abstract：:Experiments were performed to test several predictions of the hypothesis that activity pattern-dependent changes in intracellular free calcium concentration ([Ca2+]i) might play a role in the translation of altered patterns of neuronal activity into changes in neurotransmitter gene expression. It was shown that (1) th...

journal_title：Neuroscience letters

authors： Hodaie M,Jeevaratnam P,Salter MW,Roach A

更新日期：1995-02-13 00:00:00

abstract：:Superfusion of the isolated spinal cord of neonatal rats (4-9 days postpartum) with physiological medium containing 2-chloroadenosine (2-CA) or anoxic medium (equilibrated with 95% N2-5% CO2) depressed the evoked monosynaptic reflex (MSR) recorded extracellularly from a ventral spinal root. The effectiveness of 2-CA o...

journal_title：Neuroscience letters

authors： Lloyd HG,Perkins A,Spence I

更新日期：1989-06-19 00:00:00

abstract：:The light microscopic localization of gamma-aminobutyric acidB (GABAB) receptors in the rat brain has been accomplished using in vitro autoradiography with [3H]baclofen as a ligand. Initial biochemical studies indicated this compound specifically bound to slide-mounted tissue sections with high affinity in a saturable...

journal_title：Neuroscience letters

authors： Gehlert DR,Yamamura HI,Wamsley JK

更新日期：1985-05-14 00:00:00

abstract：:In a light microscopic study the ferric ion-ferrocyanide staining of the squid giant axon was investigated. In other neurons this stain is known to indicate excitable membranes with high sodium channel density, such as the node of Ranvier or the initial segment. In the squid the stain reacted in small patches of the a...

journal_title：Neuroscience letters

authors： Greeff NG,Akert K,Sandri C

更新日期：1985-06-12 00:00:00

abstract：:To assess cortical activity during pain perception, regional cerebral blood flow (rCBF) studies were done in humans using single photon emission computed tomography (SPECT) with the radiotracer Tc99m-HMPAO and magnetic resonance imaging localization. Normalized SPECT data were analyzed by region of interest and change...

journal_title：Neuroscience letters

authors： Apkarian AV,Stea RA,Manglos SH,Szeverenyi NM,King RB,Thomas FD

更新日期：1992-06-22 00:00:00

abstract：:The Rose Bengal model in rats is widely used to study brain plasticity, functional recovery and restorative therapies. The present study evaluated temporal profiles of hemorrhage and edema by magnetic resonance imaging (MRI) in rats in relation to sensorimotor impairment after photochemically induced cortical infarct....

journal_title：Neuroscience letters

authors： Jolkkonen J,Jokivarsi K,Laitinen T,Gröhn O

更新日期：2007-11-27 00:00:00

abstract：:Cholinergic projections originating in the basal forebrain (BF) play important roles in the heterosynaptic facilitation of synaptic strength in various sensory cortices, including the primary visual cortex (V1). Here, using urethane-anesthetized rats, we find that pairing burst stimulation of the BF with single pulse ...

journal_title：Neuroscience letters

authors： Gagolewicz PJ,Dringenberg HC

更新日期：2009-10-02 00:00:00

abstract：:Effects of conceptual fusion on episodic associative retrieval were examined. Subjects attempted to fuse sequentially displayed (800 ms offset) word pairs; pairs subjects were unable to fuse were instead considered associated by juxtaposition. Next, dense-array event-related potentials (ERPs) were recorded while the p...

journal_title：Neuroscience letters

authors： Kounios J,Bachman P,Casasanto D,Grossman M,Smith RW,Yang W

更新日期：2003-07-24 00:00:00

abstract：:The breakdown in brain ionic homeostasis during energy deprivation (anoxic depolarization [AD]) is intimately linked to neuronal injury. We studied the role of one particular route of Na+ influx, voltage-sensitive Na+ channels, in the AD induced by O2 and/or glucose deprivation. We recorded extracellular Na+ concentra...

journal_title：Neuroscience letters

authors： Fung ML,Croning MD,Haddad GG

更新日期：1999-11-05 00:00:00

abstract：:GABA transaminase activity is reduced in autopsied putamen samples from patients dying with Huntington's disease. Its activity is also reduced in the striatum of rats previously lesioned with kainic acid. In both cases, the reduction in GABA transaminase activity is comparable with the reduction in glutamate decarboxy...

journal_title：Neuroscience letters

authors： Carter CJ

更新日期：1984-08-10 00:00:00

abstract：:There is controversy as to what extent the processing of spectrally rich sounds in the human auditory cortex is related to the processing of singular frequencies. An informative index of the function of the auditory cortex, particularly important in neurological patients, is the mismatch negativity (MMN), a component ...

journal_title：Neuroscience letters

authors： Kotchoubey B,Lang S,Herb E,Maurer P,Schmalohr D,Bostanov V,Birbaumer N

更新日期：2003-12-04 00:00:00

abstract：:The activity of the septo-hippocampal cholinergic pathway was investigated by measuring changes in the extracellular acetylcholine (ACh) levels in the hippocampus, by means of microdialysis, during the operant conditioned reflex and the repeated footshock stimulus. Microdialysis samplings were conducted in a Skinner b...

journal_title：Neuroscience letters

authors： Dong Y,Mao J,Shangguan D,Zhao R,Liu G

更新日期：2004-10-14 00:00:00

abstract：:By studying the binding of [3H]glycine and [3H]glutamate to rat synaptic membranes in the presence of 2-amino-5-phosphonovalerate (APV) and kynurenate (KYN) we have demonstrated that KYN is more potent than APV in displacing [3H]glycine, while an opposite order of potency was seen in displacing [3H]glutamate. Moreover...

journal_title：Neuroscience letters

authors： Danysz W,Fadda E,Wroblewski JT,Costa E

更新日期：1989-01-30 00:00:00

abstract：:Drug addiction is a process that transits from recreative and regular drug use into compulsive drug use. The two patterns of drug use, controlled drug intake and escalated drug intake, represent different stages in the development of drug addiction; and escalation of drug use is a hallmark of addiction. Accumulating s...

journal_title：Neuroscience letters

authors： Du HY,Cao DN,Chen Y,Wang L,Wu N,Li J

更新日期：2016-01-12 00:00:00

abstract：:We identified a 45-kDa protein by 2D electrophoresis that was enhanced following pentylenetetrazol (PTZ)-mediated seizures. Mass-spectrography of this protein revealed the beta subunit of Ca2+/calmodulin-dependent protein kinase II (CaMKIIbeta), although no evidence for increase in bulk CaMKIIbeta transcripts was obta...

journal_title：Neuroscience letters

authors： Matsu-ura T,Nakadai T,Oda Y,Nagasu T,Mikoshiba K,Tamura TA

更新日期：2002-04-12 00:00:00

abstract：:The latency, duration of feeding and number of feeding periods recorded from rats after noradrenaline injection to the hippocampus show little change after unilateral 6-hydroxydopamine injections to the substantia nigra. It is suggested that 6-hydroxydopamine-induced weight losses result from non-specific effects of i...

journal_title：Neuroscience letters

authors： Oades RD

更新日期：1977-04-01 00:00:00

abstract：:It is well established that calcium-dependent neurotransmitter release and exocytosis can be regulated by altering the cholesterol content of the plasma membrane. We have compared the influence of cholesterol depletion of synaptosomal plasma membrane by 15 mM methyl-beta-cyclodextrin (MCD) treatment on calcium-depende...

journal_title：Neuroscience letters

authors： Waseem TV,Kolos VA,Lapatsina LP,Fedorovich SV

更新日期：2006-09-11 00:00:00

abstract：:The antigenic components of Lewy bodies in the cerebral cortex and substantia nigra in 5 cases of diffuse Lewy body disease were examined by immunocytochemistry, using antibodies to neurofilaments (in the phosphorylated or non-phosphorylated forms); to ubiquitin; to the microtubule-associated proteins MAP1, MAP2 and t...

journal_title：Neuroscience letters

authors： Galloway PG,Bergeron C,Perry G

更新日期：1989-05-22 00:00:00

abstract：:Amyloid beta (A beta) is a normal proteolytic fragment of a large precursor protein (beta PP) which undergoes altered conformation, leading to fibril formation. Two main beta PP processing pathways have been described, and we are now reporting the characterization of a third beta PP pathway. A membrane-associated 16 k...

journal_title：Neuroscience letters

authors： Ghiso J,Gardella JE,Liem L,Gorevic PD,Frangione B

更新日期：1994-04-25 00:00:00

abstract：:To light illumination retinal amacrine cells respond with graded depolarization accompanied by a spike discharge. It has been assumed that the graded depolarization is produced solely by the excitatory synaptic inputs from bipolar cells. Here we demonstrate that a tetrodotoxin (TTX)-sensitive persistent current also c...

journal_title：Neuroscience letters

authors： Watanabe S,Satoh H,Koizumi A,Takayanagi T,Kaneko A

更新日期：2000-01-07 00:00:00

abstract：:By means of extracellular recordings, we studied thalamic ventrobasal complex neurons of rats tested first awake, and then anesthetized with pentobarbital. In both conditions, we found two groups of units in both states. The first group, displaying a spontaneous bursting activity, was not obviously responding to perip...

journal_title：Neuroscience letters

authors： Montagne-Clavel J,Olivéras JL

更新日期：1995-08-18 00:00:00